JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2013, Vol. 51 ›› Issue (1): 33-36.
• Articles • Previous Articles Next Articles
JIANG Xin1, GUO Wen-bin1, ZHU Mei1, LI Qiao1, JIANG Ting2, ZHANG Shuo1
Received:
Online:
Published:
Abstract:
Objective To prepare PLGA [poly (lactic-co-glycolic acid)] as the sustained-releasing microspheres loaded with paclitaxel and to evaluate the treatment effect on the implanted tumor induced by Skov3 cells in the nude mice. Methods Four-week-old female BALB/c-nu mice were used as tumor models by injecting Skov3 cells at the back side, and they were evenly divided into four groups. And inner tumor injection was done by using physiological saline, the PLGA microspheres, the paclitaxel and the paclitaxel loaded PLGA microspheres separately. Then the mice were treated and observed and the tumor growth curves were recorded.Direct inner tumor injection was done and the MVD and Bad was measured by immunohistochemistry. Results After 6 weeks of treatment, tumor size and volume of tumor models treated with PLGA sustained-releasing microspheres loaded with paclitaxel were significantly decreased, compared with those of other groups(P<0.05). Conclusion PLGA sustained-releasing microspheres loaded with paclitaxel by direct inner tumor injection has a remarkably inhibitory effect on ovarian cancer.
Key words: Poly lactic-co-glycolic acid; Microsphere; Paclitaxel; Ovarian neoplasms
CLC Number:
JIANG Xin1, GUO Wen-bin1, ZHU Mei1, LI Qiao1, JIANG Ting2, ZHANG Shuo1. Treatment effect of paclitaxel loaded microspheres in Skov3 tumor-bearing nude mice[J].JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2013, 51(1): 33-36.
0 / / Recommend
Add to citation manager EndNote|Reference Manager|ProCite|BibTeX|RefWorks
URL: http://yxbwk.njournal.sdu.edu.cn/EN/
http://yxbwk.njournal.sdu.edu.cn/EN/Y2013/V51/I1/33
Cited