Abstract:

Objective   To prepare PLGA ［poly (lactic-co-glycolic acid)］ as the sustained-releasing microspheres loaded with paclitaxel and to evaluate the treatment effect on the implanted tumor induced by Skov3 cells in the nude mice. Methods   Four-week-old female BALB/c-nu mice were used as tumor models by injecting Skov3 cells at the back side, and they were evenly divided into four groups. And inner tumor injection was done by using physiological saline, the PLGA microspheres, the paclitaxel and the paclitaxel loaded PLGA microspheres separately. Then the mice were treated and observed and the tumor growth curves were recorded.Direct inner tumor injection was done and the MVD and Bad was measured by immunohistochemistry. Results   After 6 weeks of treatment, tumor size and volume of tumor models treated with PLGA sustained-releasing microspheres loaded with paclitaxel were significantly decreased, compared with those of other groups(P＜0.05). Conclusion   PLGA sustained-releasing microspheres loaded with paclitaxel by direct inner tumor injection has a remarkably inhibitory effect on ovarian cancer.

Key words: Poly lactic-co-glycolic acid； Microsphere; Paclitaxel; Ovarian neoplasms