Abstract:

Objective   To observe the effects of Qindan Capsule (QD) on inhibition of ventricular hypertrophy and the expression of NF-κB in spontaneously hypertensive rats (SHR) by way of activating PPARγ so as to investigate the mechanism of QD reversing hypertension ventricular hypertrophy. Methods   Spontaneously hypertensive rats（SHR）were divided into the model group（SHR group）, QD high dosage group（SHR+QDH group）, QD low dosage group（SHR+QDL group）, and SHR+Telmisartan group（SHR+Tel group）. Wistar-Kyoto group（WKY）rats of the same weeks were taken as the normal control（WKY group）. All rats were administered with corresponding medicine or normal saline. Animal blood pressures were measured by tail-cuff plethysmography.Morphological changes of myocardial tissue were evaluated by HE staining. Ultramicrostructural changes of myocyte were determined by transmission electron microscopy. Expressions of PPARγ and NF-KB were detected by immunohistochemical staining. Results   Compared with those of the SHR group, the systolic blood pressures and the myocardial expressions of NF-κB in the SHR+QDH group, SHR+QDL group and SHR+Tel group were significantly reduced by QD or Tel (P<0.05). In the contrast, the myocardial expressions of PPARγ in the SHR+QDH group, SHR+QDL group and SHR+ Tel group increased by QD or Tel compared to those of the SHR group (P<0.05). The extent of ventricular hypertrophy in the SHR+QDH group was drasticly less than that in the SHR+QDL group(P<0.05). Conclusion   QD ameliorates the ventricular hypertrophy by enhancing the PPARγ expression so as to suppressing the NF-KB expression in myocyte.

Key words: Qindan capsule;  Ventricular hypertrophy;   Spontaneously hypertensive rats；Peroxisome proliferater-activated receptor γ； Nuclear factor kappa-B