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Relationship of hypoxiainducible factor1α and Endoglin in the placenta with the serum soluble endoglin in preeclampsia

SHANG Hui1,　CHEN Lijun1,　XING Jing2
   

  1. （1. Department of Obstetrics, Qilu Hospital of Shandong University, Jinan 250012, China;
    2. Department of Obstetrics, Chinese People′s Armed Police Forces Hospital,Tianjin 300162, China）
  • Received:1900-01-01 Revised:1900-01-01 Published:2009-04-16
  • Contact: CHEN Lijun

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Abstract: To investigate expressions of hypoxiainducible factor1α and Endoglin in the placenta and the serum soluble endoglin in preeclampsia. MethodsExpressions of HIF1α and Endoglin in the placenta collected from 40 pregnant women with preeclampsia（including mild and severe preeclampsia）and 20 normal pregnant women were determined by immunohistochemistry. The level of soluble endoglin in the serum was detected by enzyme linked immunosorbent assay. Results①Expressions of HIF1α and Endoglin protein in preeclampsia placenta were significantly higher than those in normal placenta (P<0.01), and were higher in the severe group than those in the mild group (P<0.01). ② The level of sEng in the serum of the preeclampsia group was significantly higher than that of the controls (P＜0.01) and was higher in the severe group than in the mild group(P<0.01). ③In the preeclampsia group, HIF1α expression in the placenta was positively correlated with expression of Endoglin in the placenta(r=0.686) and in the serum level（r=0.866). ConclusionAbnormal excess expression of HIF1α in the placenta may induce high expression of Endoglin in the placenta and sEng in the serum, which may be involved in the pathophysiological processes of preeclampsia.

Key words: Preeclampsia, Placenta, HIF1α, Endoglin, Soluble endoglin

CLC Number: 

  • R714.24
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