JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

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A rat model for studying water and sodium metabolism following cervical spinal cord injury

LIU Yang, JIA Tanghong, GONG Weiming, NING Bin, GUO Shuya,
SONG Hongliang, XU Peng, ZHANG Tao, ZHANG Laibo
  

  1. (Department of Orthopaedics, Jinan Central Hospital Affiliated to Shandong University, Jinan 250013, China)
  • Received:1900-01-01 Revised:1900-01-01 Online:2009-03-16 Published:2009-03-16
  • Contact: JIA Tanghong

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Abstract: To establish a rat model of cervical spinal cord injury(SCI) for exploring the mechanism of metabolic disturbance of water and sodium after cervical SCI. MethodsFortyfive female adult Wistar rats were randomly divided into three groups: fifteen in group A were fed with normal rodent food without surgeries (the control group), fifteen in group B were fed with enteral nutritional emulsion(TP) and subjected to gastrostomy after lesions of the paravertebral muscles (the sham group), and fifteen in group C were fed with TP and subjected to gastrostomy after cervical spinal cord transaction (SCT) and urethral catheterization (the experimental group). The urine volume and concentration of sodium in blood and urine were determined. ResultsCompared with group B, group C had hyponatremia four days after the operations (P<0.05). Blood sodium concentration was not obviously different between group A and groups B and C preoperatively（P＞0.05）. ConclusionHyponatremia happens after cervical spinal cord injury in rats.

Key words: Spinal cord injury, Metabolism, Models,animal, Rats,Wistar

CLC Number: 

  • Ｒ681.5
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