JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

• Articles • Previous Articles     Next Articles

Effects of immunoglobulin on GABA receptors and expression of GAD in epileptic rats

YAN Hui-lan1，WANG Juan2，ZHAO Li-xia1   

  1. 1. Department of Pharmacy， 2. Department of Drug Purchase and Supply, Qilu Hospital of Shandong University, Jinan 250012, China
  • Received:2007-09-03 Revised:1900-01-01 Online:2008-01-16 Published:2008-01-16
  • Contact: YAN Hui-lan

PDF (PC)

539

Abstract: To study the effects of immunoglobulin on the number of GABA receptors, the expression of GAD and cell apoptosis. Methods Forty healthy SD rats were randomly divided into the blank control group, the epilepsy model control group, the epilepsy model saline (NS) pretreatment group and the epilepsy model immunoglobulin pretreatment group. After being decapitated, the number of GABA receptors, the expression of GAD and cell apoptosis in the brains were determined. ResultsAfter seizures, the number of GABA receptors and the expression of GAD were higher in the model group than those in the control group. After immunoglobulin pretreatment, the number of GABA receptors and the expression of GAD were significantly increased while the number of apoptosis was decreased in the model group. Conclusion Immunoglobulin can control epilepsy by enhancing the expression of GAD and blocking apoptosis.

Key words: Epilepsy, Rats, Immunoglobulin, Receptors, GABA

CLC Number: 

  • R285.5
[1] ZHU Lin, HU San-Yuan, ZHANG Guang-Yong, DING Xiang-Jiu. Protection of PGE2 against intestinal mucosa injuries in obstructed jaundice rats [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2209, 47(6): 12-.
[2] SUN Tao, ZHANG Dao-Lai, XIE Shan-Shan, WANG Yu-Zhuo, FENG Yu-Xin, XIN Hua. Effect of ethanol on expression of connexin 43 in primary culture of neural precursor cells [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2209, 47(6): 20-.
[3] ZHANG Dao-Lai, SUN Tao, XIE Shan-Shan, WANG Yu-Zhuo, ZHAO Ling, FENG Yu-Xin, XIN Hua. Developmental expression of NMDAR1 subunit on cultured cerebral cortical neurons of fetal rats in vitro [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2209, 47(6): 28-32.
[4] GE Li-Juan, JIN Rui-Feng, WANG Ji-Wen, HU Xin-Sheng, LIKun. Association between the C1236T polymorphism in multi-drug resistance gene 1 and response to antiepileptic drug treatment in epileptic patients [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2209, 47(6): 99-102.
[5] SUO Dongyang, SHEN Fei, GUO Hao, LIU Lichang, YANG Huimin, YANG Xiangdong. Expression and mechanism of Tim-3 in animal model of drug-induced acute kidney injury [J]. Journal of Shandong University (Health Sciences), 2020, 1(7): 1-6.
[6] ZHANG Liang, XU Min, ZHUANG Xianghua, LOU Fuchen, LOU Nengjun, LÜ Li, GUO Wenjuan, ZHENG Fengjie, CHEN Shihong. An investigation of endoplasmic reticulum stress and apoptosis in diabetic peripheral neuropathy [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(8): 13-17.
[7] LI Yan, GUO Jun, WANG Rongqi, LIU Yongling. Sturge-Weber syndrome in patients with intractable epilepsy: a clinicopathologic study of 7 cases [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(4): 91-95.
[8] XIE Haibin, WU Qunzheng, LIU Shaozhuang, HUANG Xin, CHENG Yugang, HU Sanyuan, ZHANG Guangyong. Role of mitochondria-associated membranes in the improvement of insulin sensitivity in diabetic rats after sleeve gastrectomy [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(10): 36-40.
[9] ZHAO Lu, JIAO Jun, ZHANG Teng, JIAO Xinlin, CUI Baoxia. Expression of LXRα in ovarian carcinoma and effects of T0901317 on SKOV3 cell line [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(1): 49-53.
[10] CHEN Yihui, LIU Xuewei, HOU Xuhao, SUN Qinfeng. Study of mouse alveolar bone defect reparation by dialdehyde bletilla striata glucomanna / hydroxypropyl chitosan / nano-nacre powder composited scaffolds [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(6): 7-11.
[11] LI Hongzhi, LIU Jing, SONG Yan, CHI Lingyi, LIU Yuguang. Role of liraglutide in the repair of spinal cord injury [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(4): 1-5.
[12] SUN Yongfeng, LIU Huizhao, ZHONG Jianwei, WANG Tao, YUAN Jun, ZHAI Weidong. Ultrasound guidance and electrophysiological monitoring in microsurgical treatment of 6 cases of cavernous hemangioma in children with secondary epilepsy [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(4): 55-59.
[13] GUAN Jingyun, YANG Yang, QIU Chunhong, LI Xiangzhi. Role of histone acetyltransferase MOF in the pathogenesis of multiple sclerosis [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(2): 27-32.
[14] JIA Junwei, ZHOU Xueying, LI Qiuhong, YU Kai, ZHOU Guoyu, ZHOU Shengnian. Expression of Annexin A7 in brain tissue of pilocarpine-induced epilepsy mouse model [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(10): 6-10.
[15] REN Baoxin, MA Yunfeng, LIU Dianwei, LI Zhuo, JIANG Yong. Effects of Wnt3a on neuronal autophagy and apoptosis in early brain injury after subarachnoid hemorrhage in rats [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(10): 11-15.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Copyright 2018 © Editorial office of Journal of Shandong University (Health Sciences)
Supported by Beijing Magtech Co.Ltd