JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

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Bone alkaline phosphatase measurement and its relation with osteosarcoma

YANG Zhi-ping1, HUO Yan-qing2, SUN Guang-zhi3，LI Jian-min1, LI Xin1   

  1. 1. Department of Orthopaedics, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China;2. Department of Orthopaedics, Second Hospital of Shandong University, Jinan 250033, Shandong, China;
  • Received:2005-03-14 Revised:1900-01-01 Published:2006-06-25
  • Contact: YANG Zhi-ping

Abstract: To explore the value of bone alkaline phosphatase (BALP) on diagnosing osteosarcoma, evaluating the effect of chemotherapy, judging the prognosis and supervising the relapse and metastasis. Methods: The immunoassay was used to check the serum BALP in 42 patients with primary osteosarcoma, and auto biochemistry equipment to determine the serum Alkaline Phosphatase (ALP). The biopsy tissue and the lesion moved in the operation were treated with pathology, and their histological responses were counted. Results: During a followup from 5 months to 49 months with an average of 24.3 months, 18 patients had relapsed or transferred osteosarcoma, 16 died, others were surviving to the end of followup. BALP was more sensitive than ALP in diagnosing osteosarcomaConclusion: As a check mark in blood serum, BALP is more sensitive to the process of ossification than ALP, and therefore it is valuable in the diagnosis of osteosarcoma, reflection of the effect of chemotherapy and forecast of the prognosis.

Key words: Osteosarcoma, Alkaline Phosphatase, Isoenzymes

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