Journal of Shandong University (Health Sciences) ›› 2025, Vol. 63 ›› Issue (9): 65-76.doi: 10.6040/j.issn.1671-7554.0.2025.0310

• Review • Previous Articles    

Research progress on the function and mechanism of lactylation in the process of tumor inflammation and cancer

LI Xuekai1, SUN Linhan1, LIU Duanrui2, NI Yang1   

  1. 1. Department of Oncology;
    2. Department of Laboratory Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, Shandong, China
  • Published:2025-09-08

Abstract: Lactylation modification, as a novel post-translational modification(PTM)of proteins, is one of the main mechanisms of epigenetic regulation. It can affect the structure, function, activity and stability of proteins. Lactylation modification provides a new perspective for better understanding the connection between cellular metabolic reprogramming and epigenetic regulation. Recently, studies have increasingly found that lactylation modification regulates tumor proliferation and drug resistance by participating in the inflammatory-cancer process. It promotes inflammatory-cancer transformation and immunosuppression and is closely related to poor tumor prognosis. Understanding the molecular mechanism of lactylation modification provides new perspectives and strategies for tumor treatment, and promotes the transformation of lactate research from basic research to clinical applications. This article reviews the roles of lactylation metabolism and modification in the inflammatory-cancer process, highlighting their key roles in multiple tumors such as gastrointestinal and liver tumors. These findings are important for exploring the mechanism of tumor occurrence and development, as well as for identifying new therapeutic targets.

Key words: Eactic acid, Lactylation modification, Tumor, Inflammatory-cancer progression, Treatment

CLC Number: 

  • R73-3
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