Journal of Shandong University (Health Sciences) ›› 2023, Vol. 61 ›› Issue (11): 11-19.doi: 10.6040/j.issn.1671-7554.0.2023.0981

• Academic Frontiers • Previous Articles     Next Articles

Technical procedure of CT-guided intratumoral chemotherapy for lung tumor

Mingyong HAN1,*(),Xiaoli YU1,Fangping ZENG1,Bing XIE2,Lan LU1,Jiaquan QU1,Bifeng JIANG1,Sihan TANG1,Jie TAN1,Jin LIANG1,Longhui ZHONG1,Liu WANG1,Xuanzhi ZHAO1   

  1. 1. Department of Oncology, South China Hospital of Shenzhen University, Shenzhen 518111, Guangdong, China
    2. Department of Radiology, South China Hospital of Shenzhen University, Shenzhen 518111, Guangdong, China
  • Received:2023-11-02 Online:2023-11-10 Published:2023-12-12
  • Contact: Mingyong HAN E-mail:hanmingyong@sina.com

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Abstract:

The incidence and mortality rates of lung cancer in China rank the first of all tumors. At present, there are many effective treatment methods, including surgery, chemotherapy, radiotherapy, targeted therapy, immunotherapy and other local and systematic treatments. In recent years, intratumoral chemotherapy, which combines the advantages of local therapy and systemic therapy, has gradually become the focus. By using ultrasound, bronchoscope, ultrasonic bronchoscope, endoscopic ultrasonography or CT and other imaging and interventional modalities, chemotherapeutics such as cisplatin, carboplatin, mitomycin, paclitaxel liposomes, fluorouracil in stock or diluted solutions are directly injected into the cancer tissue through the puncture needle. Intratumoral chemotherapy can increase the concentration of chemotherapeutics in the tumor tissue, reduce the systemic toxicity and side effects, and improve the local control rate of cancers. We have carried out clinical application and exploratory research on intratumoral chemotherapy for lung cancer, liver metastasis and bone metastasis, and observed patients' benefits and primary efficacy. This paper will summarize the technical procedure of CT-guided intratumoral chemotherapy.

Key words: Intratumoral chemotherapy, Lung tumor, CT-guided, Technical procedure

CLC Number: 

  • R734.2

Fig.1

Positioning the patient before operation and making a visible mark of the point of puncture A: Positioning the patient before operation and placing the CT plotting sheet; B: Performing CT scan; C: Choosing the point of puncture; D: Making a visible mark on the skin."

Fig.2

Anesthesia and puncture A: Checking the puncture needle before puncture and emptying the air inside the tube; B: Inserting the puncture needle slowly after local infiltration anesthesia; C: Injecting the puncture needle into the cancer tissue; D: Adjusting the puncture needle to the planned position."

Fig.3

Drug injection and complications A: Inserting the tip of the puncture needle into the farthest point of the lung tumor; B: Downstream reaction of ITC; C: Small pneumothorax; D: Severe pneumothorax."

Fig.4

Technical procedure of CT-guided intratumoral chemotherapy for lung tumor"

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