Journal of Shandong University (Health Sciences) ›› 2023, Vol. 61 ›› Issue (10): 88-94.doi: 10.6040/j.issn.1671-7554.0.2023.0202

Previous Articles     Next Articles

Outcome and influencing factors of 314 outpatient smoking cessation cases

QIU Yifan1, WANG Zihan1, GAO Tingting2, WANG Xiyan2, SUN Yan2, LIU Fen2, QI Qian2, DONG Liang1,2   

  1. 1. Department of Respiratory, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan 250014, Shandong, China;
    2. Department of Respiratory, The First Affiliated Hospital of Shandong First Medical University &
    Shandong Provincial Qianfoshan Hospital, Shandong Institute of Respiratory, Jinan 250014, Shandong, China
  • Published:2023-11-08

PDF (PC)

107

Abstract: Objective To compare the effects of drug quitting and psychological behavior intervention on smoking cessation, and to compare the success rate of smoking cessation after 1, 3 and 6 months of follow-up in the real world. Methods During Jun. 1, 2022 and Dec. 31, 2022, 314 smoking cessation patients registered in the Smoking Cessation Clinic of Shandong Provincial Qianfoshan Hospital were divided into two groups according to different ways of intervention. The medication-assisted group included 178 smokers who chose to use drugs(113 used Bupropion, 38 used Varenicline and 27 used Nicotine patches), while the control group included 136 patients who accepted the psychological behavioral intervention. The smoking cessation rate of the two groups after 1 month, 3 months and 6 months were analyzed with SPSS 26.0 software to identify the differences in the effects of interventions and the influencing factors. Results The success rate of drug-assisted quitters was 48.3%, the success rate of psychological behavioral quitters was 13.2%, with statistically significant difference between the two groups(χ2=51.714, P<0.05). Smokers with a bachelors degree or above and a daily smoking limit of less than 1 box(20 cigarettes)were more likely to quit smoking, which were protective factors for smoking cessation success. Conclusion Drug-assisted smoking cessation and psychological behavior intervention are both good ways to assist smoking cessation. The former is more helpful, especially in reducing the rate of relapse.

Key words: Tobacco dependence, Smoking cessation, Bupropion, Varenicline, Nicotine patches, Psychological behavior intervention, Success rate of smoking cessation

CLC Number: 

  • R193
[1] Picciotto MR, Kenny PJ. Mechanisms of nicotine addiction[J]. Cold Spring Harb Perspect Med, 2021, 11(5): a039610. doi: 10.1101/cshperspect.a039610.
[2] Wang M, Luo X, Xu S, et al. Trends in smoking prevalence and implication for chronic diseases in China: serial national cross-sectional surveys from 2003 to 2013[J]. Lancet Respir Med, 2019, 7(1): 35-45.
[3] Liu Z, Li YH, Cui ZY, et al. Prevalence of tobacco dependence and associated factors in China: findings from nationwide China Health Literacy Survey during 2018-19[J]. Lancet Reg Health West Pac, 2022, 24: 100464. doi: 10.1016/j.lanwpc.2022.100464.
[4] DiFranza JR. Can tobacco dependence provide insights into other drug addictions? [J] BMC Psychiatry, 2016, 16(1): 365. doi: 10.1186/s12888-016-1074-4.
[5] GBD 2019 Tobacco Collaborators. Spatial, temporal, and demographic patterns in prevalence of smoking tobacco use and attributable disease burden in 204 countries and territories, 1990-2019: a systematic analysis from the Global Burden of Disease Study 2019[J]. Lancet, 2021, 397(10292): 2337-2360.
[6] Xie L, Yan Y, Yang Y, et al. Evaluation of smoking cessation intervention effectiveness in smoking cessation clinics-China, 2019-2021[J]. China CDC Wkly, 2023, 5(21): 469-474.
[7] Lin B, Xie L, Xie X, et al. Predictors for quitting smoking in smoking cessation clinics among female smokers in China[J]. Tob Induc Dis, 2023, 21: 26. doi: 10.18332/tid/159132.
[8] Chan KH, Wright N, Xiao D, et al. Tobacco smoking and risks of more than 470 diseases in China: a prospective cohort study[J]. Lancet Public Health, 2022, 7(12): e1014-e1026.
[9] GBD 2017 Disease and Injury Incidence and Prevalence Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017: a systematic analysis for the global burden of disease study 2017[J]. Lancet, 2018, 392(10159): 1789-1858.
[10] Fallahzadeh A, Sharifnejad Tehrani Y, Sheikhy A, et al. The burden of chronic respiratory disease and attributable risk factors in North Africa and Middle East: findings from global burden of disease study(GBD)2019[J]. Respir Res, 2022, 23(1): 268. doi: 10.1186/s12931-022-02187-3.
[11] Sun J, Bao J, Shi Y, et al. Effect of simvastatin on MMPs and TIMPs in cigarette smoke-induced rat COPD model[J]. Int J Chron Obstruct Pulmon Dis, 2017, 12: 717-724. doi: 10.2147/COPD.S110520.
[12] Arreola-Ramírez JL, Vargas MH, Carbajal V, et al. Mesenchymal stem cells attenuate the proinflammatory cytokine pattern in a guinea pig model of chronic cigarette smoke exposure[J]. Cytokine, 2023, 162: 156104. doi: 10.1016/j.cyto.2022.156104.
[13] Serré J, Mathyssen C, Ajime TT, et al. Airway infection with nontypeable haemophilus influenzae is more rapidly eradicated in vitamin D deficient mice[J]. J Steroid Biochem Mol Biol, 2019, 187: 42-51. doi: 10.1016/j.jsbmb.2018.10.021.
[14] Pournaras N, Andersson A, Kovach MA, et al. Glucose homeostasis in relation to neutrophil mobilization in smokers with COPD[J]. Int J Chron Obstruct Pulmon Dis, 2022, 17: 1179-1194. doi: 10.2147/COPD.S353753.
[15] Martinez FJ, Han MK, Allinson JP, et al. At the root: defining and halting progression of early chronic obstructive pulmonary disease[J]. Am J Respir Crit Care Med, 2018, 197(12): 1540-1551.
[16] Chang JT, Anic GM, Rostron BL, et al. Cigarette smoking reduction and health risks: a systematic review and meta-analysis[J]. Nicotine Tob Res, 2021, 23(4): 635-642.
[17] 李文扬,康健.235例戒烟志愿者戒烟成功及失败因素分析[J].贵阳医学院学报, 2015, 40(5): 479-481. LI Wenyang, KANG Jian. Analysis of the failure factors of smoke quitting[J]. Journal of Guiyang Medical College, 2015, 40(5): 479-481.
[18] 葛福婷,张秀,王家豪,等.基于层次分析法的吸烟者戒烟影响因素研究[J].商丘师范学院学报, 2017, 33(6): 5-12. GE Futing, ZHANG Xiu, WANG Jiahao, et al. Research on the influencing factors for smokers to quit smoking from the perspective of analytic hierarchy process[J]. Journal of Shangqiu Normal University, 2017, 33(6): 5-12.
[19] Sharma MK, Suman LN, Srivastava K, et al. Psychometric properties of fagerstrom test of nicotine dependence: a systematic review[J]. Ind Psychiatry J, 2021, 30(2): 207-216.
[20] Cinciripini PM, Minnix JA, Robinson JD, et al. The effects of scheduled smoking reduction and precessation nicotine replacement therapy on smoking cessation: Randomized Controlled Trial With Compliance[J]. JMIR Form Res, 2023, 7: e39487. doi: 10.2196/39487.
[21] Hartmann-Boyce J, Aveyard P. Drugs for smoking cessation[J]. BMJ, 2016, 352: i571. doi: 10.1136/bmj.i571.
[22] 李荣,解世林,张励,等.盐酸安非他酮缓释片联合行为干预真实世界戒烟效果研究[J].中国实用内科杂志, 2019, 39(10): 873-878. LI Rong, XIE Shilin, ZHANG Li, et al. A study on the real world effect of the combination of bupropion hydrochloride sustained release tablets with behavior intervention on smoking cessation[J]. Chinese Journal of Practical Internal Medicine, 2019, 39(10): 873-878.
[23] Jordan CJ, Xi ZX. Discovery and development of varenicline for smoking cessation[J]. Expert Opin Drug Discov, 2018, 13(7): 671-683.
[24] Lopes LC, Zhang Y, Ross S, et al. Varenicline for tobacco-dependent adults who are not ready to discontinue use: a systematic review and meta-analysis[J]. Ann Am Thorac Soc, 2022, 19(12): 2077-2086.
[25] Hernández Zenteno RJ, Lara DF, Venegas AR, et al. Varenicline for long term smoking cessation in patients with COPD[J]. Pulm Pharmacol Ther, 2018, 53: 116-120. doi: 10.1016/j.pupt.2018.11.001.
[26] Tavares Xda S, Blum AP, Nakamura DT, et al. Variations in binding among several agonists at two stoichiometries of the neuronal, α4β2 nicotinic receptor[J]. J Am Chem Soc, 2012, 134(28): 11474-11480.
[27] Tonstad S, Arons C, Rollema H, et al. Varenicline: mode of action, efficacy, safety and accumulated experience salient for clinical populations[J]. Curr Med Res Opin, 2020, 36(5): 713-730.
[28] Kim JS, Jang JY, Park EH, et al. Seven-day continuous abstinence rate from smoking at 1, 2, or 3 years after the use of varenicline[J]. Tuberc Respir Dis(Seoul), 2015, 78(2): 92-98.
[29] Mao RL, Cécile Tromeur, Paleiron N, et al. Effect of early initiation of varenicline on smoking cessation in COPD patients admitted for exacerbation: the save randomized clinical trial[J]. COPD, 2020, 17(1): 7-14.
[30] 商雪,鄂芬芬,郭康乐,等.伐尼克兰戒烟有效性及安全性的Meta分析和试验序贯分析[J]. 中国医院药学杂志, 2023, 43(2): 190-200. SHANG Xue, E Fenfen, GUO Kangle, et al. Effectiveness and safety of varenicline on smoking cessation: a Meta-analysis with trial sequential analysis[J]. Chinese Jounal of Hospital Pharmacy, 2023, 43(2): 190-200.
[31] Wang Q, Dai R, Zhang H, et al. The efficacy and safety of acupuncture and nicotine replacement therapy for smoking cessation: study protocol for a randomized controlled trial[J]. Trials, 2022, 23(1): 465. doi: 10.1186/s13063-022-06384-9.
[32] Zhang B, Cohen JE, Bondy SJ, et al. Duration of nicotine replacement therapy use and smoking cessation: a population-based longitudinal study[J]. Am J Epidemiol, 2015, 181(7): 513-520.
[33] Prochaska JO, Goldstein MG. Process of smoking cessation. Implications for clinicians[J]. Clin Chest Med, 1991, 12(4): 727-735.
[34] 徐鸣丽,金媛. 5A+5R干预联合伐尼克兰对COPD患者戒烟效果及肺功能的影响[J]. 临床肺科杂志, 2020, 25(6): 843-846. XU Mingli, JIN Yuan. Effect of 5A + 5R intervention combined with varenicline on smoking cessation and pulmonary function in patients with COPD[J]. Journal of Clinical Pulmonary Medicine, 2020, 25(6): 843-846.
[1] LI Yan, LIU Kun, SUN Xiaojie. Health inequality related to income and influencing factors of the rural elderly in three counties of Shandong Province [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(6): 91-96.
[2] LIU Xinyu, WANG Quan, JU Haojie, SUN Xiaojie. Mediating effect of cognition on the relationship between social capital and functional health of elderly people [J]. Journal of Shandong University (Health Sciences), 2021, 59(11): 100-107.
[3] XIA Yu, CHEN Ren, CHEN Fei, LI Boyang, PAN Xinfeng, GAO Xiang, LI Chengyue, XU Lingzhong. Correlation between health literacy,maternal mortality and infant mortality in Shanghai residents from 2008 to 2017 [J]. Journal of Shandong University (Health Sciences), 2019, 57(12): 97-102.
[4] . Qualitative analysis on factors influencing popularization of  the appropriate health technology in rural areas [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2009, 47(7): 133-135.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] SUO Dongyang, SHEN Fei, GUO Hao, LIU Lichang, YANG Huimin, YANG Xiangdong. Expression and mechanism of Tim-3 in animal model of drug-induced acute kidney injury[J]. Journal of Shandong University (Health Sciences), 2020, 1(7): 1 -6 .
[2] MA Qingyuan, PU Peidong, HAN Fei, WANG Chao, ZHU Zhoujun, WANG Weishan, SHI Chenhui. Effect of miR-27b-3p regulating SMAD1 on osteosarcoma cell proliferation, migration and invasion[J]. Journal of Shandong University (Health Sciences), 2020, 1(7): 32 -37 .
[3] ZHANG Baowen, LEI Xiangli, LI Jinna, LUO Xiangjun, ZOU Rong. miR-21-5p targeted TIMP3 to inhibit proliferation and extracellular matrix accumulation of mesangial cells in Type II diabetic nephropathy mice[J]. Journal of Shandong University (Health Sciences), 2020, 1(7): 7 -14 .
[4] FU Jieqi, ZHANG Man, ZHANG Xiaolu, LI Hui, CHEN Hong. Molecular mechanism of Toll-like receptor 4 in the aggravation of blood lipid accumulation by inhibiting the peroxisome proliferator-activate receptor γ[J]. Journal of Shandong University (Health Sciences), 2020, 1(7): 24 -31 .
[5] LONG Tingting, XIE Ming, ZHOU Lu, ZHU Junde. Effect of Noggin protein on learning and memory abilities and the dentate gyrus structure after cerebral ischemia reperfusion injury in mice[J]. Journal of Shandong University (Health Sciences), 2020, 1(7): 15 -23 .
[6] LI Ning, LI Juan, XIE Yan, LI Peilong, WANG Yunshan, DU Lutao, WANG Chuanxin. Expression of LncRNA AL109955.1 in 80 cases of colorectal cancer and its effect on cell proliferation, migration and invasion[J]. Journal of Shandong University (Health Sciences), 2020, 1(7): 38 -46 .
[7] XU Yuxiang, LIU Yudong, ZHANG Peng, DUAN Ruisheng. A retrospective analysis of risk factors of cerebral microbleeds in 101 patients with cerebral small vessel disease[J]. Journal of Shandong University (Health Sciences), 2020, 1(7): 67 -71 .
[8] DING Xiangyun, YU Qingmei, ZHANG Wenfang, ZHUANG Yuan, HAO Jing. Correlation of the expression of insulin-like growth factor II in granulosa cells and ovulation induction outcomes of 84 patients with polycystic ovary syndrome[J]. Journal of Shandong University (Health Sciences), 2020, 1(7): 60 -66 .
[9] XIAO Juan, XIAO Qiang, CONG Wei, LI Ting, DING Shouluan, ZHANG Yuan, SHAO Chunchun, WU Mei, LIU Jianing, JIA Hongying. Comparison of diagnostic efficacy of two kinds of thyroid imagine reporting and data systems[J]. Journal of Shandong University (Health Sciences), 2020, 1(7): 53 -59 .
[10] SHI Shuang, LI Juan, MI Qi, WANG Yunshan, DU Lutao, WANG Chuanxin. Construction and application of a miRNAs prognostic risk assessment model of gastric cancer[J]. Journal of Shandong University (Health Sciences), 2020, 1(7): 47 -52 .
Copyright 2018 © Editorial office of Journal of Shandong University (Health Sciences)
Supported by Beijing Magtech Co.Ltd