Journal of Shandong University (Health Sciences) ›› 2023, Vol. 61 ›› Issue (8): 67-73.doi: 10.6040/j.issn.1671-7554.0.2022.1341

• 临床医学 • Previous Articles    

Renal transplantation in 12 pairs of ABO incompatible relatives and literature review

DING Handong1,2,3, ZHONG Jinbiao1,2,3, WANG Qin4, LIAO Guiyi1,2,3   

  1. 1. Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui, China;
    2. Institute of Urology, Anhui Medical University, Hefei 230022, Anhui, China;
    3. Anhui Province Key Laboratory of Genitourinary Diseases, Anhui Medical University, Hefei 230022, Anhui, China;
    4. Department of Pharmacy, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui, China
  • Published:2023-08-30

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Abstract: Objective To explore the perioperative management, prevention and treatment of complications of ABO incompatible relatives who underwent kidney transplantation. Methods Data of 12 pairs of donors and recipients of ABO incompatible renal transplantation completed during July 2020 and April 2021 were collected, including 2 type A donors to type O recipients and 1 type A donor to type B recipients; 6 type B donors to type O recipients and 1 type B donor to type A recipient; 2 type AB donors to type B recipients. According to the titer of blood group antibody in the first test, different desensitization treatment schemes of rituximab(rituximab), plasma exchange and immunosuppressant were adopted. The changes of perioperative blood group antibody titer, renal function and lymphocyte count were monitored. Results The blood group antibody titers of 12 recipients treated with simplified desensitization schemes reached the preoperative target. The titer of blood group antibody increased in 4 recipients within half a month after transplantation, and plasma treatment intervention was conducted. Postoperative complications such as rebound after normal creatinine, severe anemia, recurrent diarrhea, arrhythmia, heart failure and positive urinary BK virus occurred in 1 case, respectively. After treatment, the renal function recovered well. Conclusion The simplified pretreatment schemes can achieve ideal blood group antibody titer, individualized and accurate prevention and treatment of complications, and achieve satisfactory short-term curative effects.

Key words: Blood group incompatibility, Renal transplantation, Humoral rejection, Desensitization treatment, Rejection, Plasma exchange

CLC Number: 

  • R617
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