Journal of Shandong University (Health Sciences) ›› 2021, Vol. 59 ›› Issue (10): 77-81.doi: 10.6040/j.issn.1671-7554.0.2021.0771

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Detection of serum MCP-1 in 67 patients with systemic inflammatory response syndrome

GAO Jinmei1, HUANG Yingbo2, FENG Zhenzhen3   

  1. 1. Department of Laboratory, The Second Hospital of Tianjin Medical University, Tianjin 300211, China;
    2. College of Medical Technology, Tianjin Medical University, Tianjin 300202, China;
    3. Intensive Care Unit, The Second Hospital of Tianjin Medical University, Tianjin 300211, China
  • Published:2021-10-15

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Abstract: Objective To evaluate the diagnostic value of monocyte chemo-attractant protein-1(MCP-1)in systemic inflammatory response syndrome(SIRS). Methods In this prospective study, 67 SIRS patients who were admitted to the Intensive Care Unit(ICU), Department of Urology, and Department of Gastrointestinal Surgery in the Second Hospital of Tianjin Medical University during Aug. 2020 and Apr. 2021 were enrolled in the case group, and 44 people who came for physical examination were included in the control group. Enzyme-linked immunosorbent assay(ELISA)was used to detect the serum concentration of MCP-1 and the difference was compared. According to the presence of multiple organ dysfunction(MODS), the case group was subdivided into MODS group(n=26)and non-MODS group(n=41), and the serum concentration of MCP-1 was compared. The receiver operating characteristic(ROC)curve was drawn to evaluate the diagnostic efficacy of serum MCP-1 for SIRS with MODS. According to the clinical symptoms and test results, the patients were divided into the sepsis group(n=15)and non-sepsis group(n=52), and the serum concentration of MCP-1 was compared. Results The median serum MCP-1 level was 180.2(90.9-407.4)pg/mL in SIRS patients and 53.4(40.2-83.7)pg/mL in controls(P<0.001), 426.2(150.1-733.6)pg/mL in MODS group and 135.0(55.6-236.1)pg/mL in non-MODS group(P<0.001). When serum MCP-1 served as the variable, the area under the ROC curve(AUC)for the diagnostic efficacy of SIRS with MODS was 0.74, the cut-off value of serum MCP-1 corresponding to the maximum Youden index was 176.0 pg/mL, the sensitivity was 76.9% and the specificity was 65.9%. There was no significant difference in serum MCP-1 level between sepsis group and non-sepsis group(P=0.832). Conclusion Detection of serum MCP-1 level in SIRS patients has an auxiliary diagnostic value for MODS, but it cannot be used as a predictor of sepsis in SIRS patients.

Key words: Systemic inflammatory response syndrome, Sepsis, Monocyte chemo-attractant protein-1, Maximum Youden index

CLC Number: 

  • R459.7
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