Journal of Shandong University (Health Sciences) ›› 2021, Vol. 59 ›› Issue (1): 88-90.doi: 10.6040/j.issn.1671-7554.0.2020.1280

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Hepatolenticular degeneration with myasthenia gravis: a case report

GAO Xiaoli, ZHOU Xueying, ZHOU Shengnian   

  1. Department of Neurology, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China
  • Published:2021-01-09

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Abstract: Objective To investigate the correlation between hepatolenticular degeneration and myasthenia gravis. Methods The clinical data of 1 case of hepatolenticular degeneration with myasthenia gravis were analyzed and relevant literature was reviewed. Results The patient was a 20-year-old female who was diagnosed as hepatolenticular degeneration before. She was readmitted due to ptosis for one month. Fatigue test, neostigmine test, and blood test of anti-acetylcholine receptor antibody(AchR)all showed positive results. The diagnosis of myasthenia gravis with hepatolenticular degeneration was established. After administration of pyridostigmine bromide and prednisone, the patient was discharged with significant improvement of clinical symptoms. Conclusion Myasthenia gravis in this patient may not be associated with hepatolenticular degeneration. But for patients with hepatolenticular degeneration, especially those who take penicillamine, when symptoms of muscle weakness present, myasthenia gravis should be considered.

Key words: Hepatolenticular degeneration, Myasthenia gravis, Penicillamine, Acetylcholine receptor

CLC Number: 

  • R741
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