JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2016, Vol. 54 ›› Issue (3): 19-23.doi: 10.6040/j.issn.1671-7554.0.2015.928

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Effect of propofol on carbachol-induced intestinal mucosa secretion

SUN Hua1,2, TANG Shuhai3, WANG Haoyi4, AN Ning4, XU Cuiping5, ZHAO Dongbo6   

  1. 1. School of Nursing, Shandong University, Jinan 250012, Shandong, China;
    2. Department of Emergency, Shandong Cancer Hospital Affilicated to Shandong University, Jinan 250117, Shandong, China;
    3. Department of Anesthesiology, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China;
    4. Department of Physiology, School of Medicine, Shandong University, Jinan 250012, Shandong, China;
    5. Department of Human Resources, Qianfoshan Hospital Affilicated to Shandong University, Jinan 250014, Shandong, China;
    6. Department of Thoracic Surgery, Shandong Cancer Hospital Affilicated to Shandong University, Jinan 250117, Shandong, China
  • Received:2015-09-29 Online:2016-03-10 Published:2016-03-10

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Abstract: Objective To explore the effect of propofol on carbachol(CCh)-induced chloride secretion in rat ileum mucosa. Methods Cch-induced chloride secretion was measured by Ussing chamber technique. Results Propofol attenuated the CCh-stimulated increase in short-circuit current(Isc)of rat ileum mucosa in a dose-dependent manner(10-2-10-6mol/L). The propofol-evoked inhibitory effect was serosal side-dependent. Furthermore, both TTX, a Na+ channel blocker, and hexamethonium bromide, a nicotinic acetylcholine receptor antagonist, had no effect on propofol-evoked inhibitory effect. Conclusion Propofol inhibites CCh-induced intestinal secretion via basolateral mAChR pathway.

Key words: Carbachol, Acetylcholine receptor, Propofol, Intestinal secretion, Short-circuit current

CLC Number: 

  • R966
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