Journal of Shandong University (Health Sciences) ›› 2018, Vol. 56 ›› Issue (11): 111-115.doi: 10.6040/j.issn.1671-7554.0.2018.780

Previous Articles    

Effects of polycyclic aromatic hydrocarbons exposure during pregnancy on the development of infant in Qingdao City, China

CUI Jing1, SUN Zhitao1, XIE Meng2, ZHANG Qian3, WANG Bingling1, GAO Ruqin1   

  1. 1. Qingdao Municipal Center for Disease Control and Prevention, Qingdao Institute of Preventive Medicine, Qingdao 266033, Shandong, China;
    2. Division of Expanded Immunization Program, Shandong Center for Disease Control and Prevention, Jinan 250014, Shandong, China;
    3. Maternal and Child Health Care of Family Planning Service Center of Huangdao District, Qingdao 266000, Shandong, China
  • Published:2022-09-27

PDF (PC)

27

Abstract: Objective To explore the effects of polycyclic aromatic hydrocarbons(PAHs)exposure during pregnancy on the development of infants aged 6 and 12 months in a birth cohort in Qingdao City. Methods A total of 348 infants born during Jan. and Dec. 2014 were enrolled in this analysis. PAH-DNA adduct of umbilical cord blood was determined, and development quotients(DQs)were measured at the ages of 6 and 12 months with Gesell Development Inventory. The correlation between PAH-DNA adduct and DQs at the ages of 6 and 12 months was assessed with Spearman correlation analysis. The effects of PAH-DNA adduct on the DQs at the age of 12 months was evaluated with linear regression models. Results The detection rate of PAH-DAN adduct was 52.4%. The DQs of 5 functional areas ranged from 66 to 118 at the age of 6 months, and ranged from 72 to 156 at the age of 12 months. Spearman correlation 山 东 大 学 学 报 (医 学 版)56卷11期 -崔静,等.青岛人群孕期多环芳烃暴露对婴幼儿发育的影响 \=-analysis showed that the PAH-DNA adduct levels were negatively correlated with the DQs of gross motor(r=0.188), fine motor(r=0.196), and personal social behavior(r=0.180)at the age of 12 months, and the differences were statistically significant(P<0.05). After the gender of infants, age of pregnant woman, birth weight, and educational levels of pregnant woman were adjusted, the PAH-DNA adduct levels were negatively correlated with the DQs of adaptive, gross motor, fine motor, language, and personal social behavior at the age of 12 months(P<0.05). Conclusion PAHs exposure during pregnancy may have adverse effects on the development of 12-month-old infants. Reducing PAHs exposure has certain preventive effects on the early developmental damage in infants.

Key words: Polycyclic aromatic hydrocarbons, Neurodevelopment, Infant, PAH-DNA adduct

CLC Number: 

  • R114
[1] Perera F, Tang D, Whyatt R, et al. DNA damage from polycyclic aromatic hydrocarbons measured by benzo[a] pyrene-DNA adducts in mothers and newborns from Northern Manhattan, the World Trade Center Area, Poland, and China[J]. Cancer Epidemiol Biomark Prev, 2005, 14(3): 709-714.
[2] Kim JJ. Ambient air pollution: health hazards to children[J]. Pediatrics, 2004, 114(6): 1699-1707.
[3] Sanyal MK, Li YL. Deleterious effects of polynuclear aromatic hydrocarbon on blood vascular system of the rat fetus[J]. Birth Defects Res B Dev Reprod Toxicol, 2007, 80(5): 367-373.
[4] Dong W, Wang L, Thornton C, et al. Benzo(a)pyrene decreases brain and ovarian aromatase mRNA expression in Fundulus heteroclitus[J]. Aquat Toxicol, 2008, 88(4): 289-300.
[5] Takeda K, Tsukue N, Yoshida S. Endocrine-disrupting activity of chemicals in diesel exhaust and diesel exhaust particles[J]. Environ Sci, 2004, 11(1): 33-45.
[6] Wormley DD, Chirwa S, Nayyar T, et al. Inhaled benzo(a)pyrene impairs long-term potentiation in the F1 generation rat dentate gyrus[J]. Cell Mol Biol(Noisy-le-grand), 2004, 50(6): 715-721.
[7] Archibong AE, Inyang F, Ramesh A, et al. Alteration of pregnancy-related hormones and fetal survival in F-344 rats exposed by inhalation to benzo(a)pyrene[J]. Reprod Toxicol, 2002, 16(6): 801-808.
[8] 谢萌. 出生队列儿童1岁龄多环芳烃暴露对其神经发育的影响[D]. 青岛:青岛大学, 2017.
[9] Perera FP, Li Z, Whyatt R, et al. Prenatal airborne polycyclic aromatic hydrocarbon exposure and child IQ at age 5 years[J]. Pediatrics, 2009, 124(2): 195-202.
[10] Perera FP, Rauh V, Whyatt RM, et al. Effect of prenatal exposure to airborne polycyclic aromatic hydrocarbons on neurodevelopment in the first 3 years of life among Inner-City children[J]. Environ Health Perspect, 2006, 114(8): 1287-1292.
[11] Perera F, Li TY, Zhou ZJ, et al. Benefits of reducing prenatal exposure to coal-burning pollutants to childrens neurodevelopment in China[J]. Environ Health Perspect, 2008, 116(10): 1396-400.
[12] Kalia V, Perera F, Tang D. Environmental Pollutants and Neurodevelopment: Review of Benefits From Closure of a Coal-Burning Power Plant in Tongliang, China[J]. Glob Pediatr Health, 2017, 31, 4: 2333794X17721609. doi: 10.1177/2333794X17721609. eCollection 2017.
[13] Perera F, Li TY, Zhou ZJ, et al. Benefits of reducing prenatal exposure to coal-burning pollutants to childrens neurodevelopment in China[J]. Environ Health Perspect, 2008, 116(10): 1396-400.
[14] Perera FP, Rauh V, Tsai WY, et al. Effects of transplacental exposure to environmental pollutants on birth outcomes in a multiethnic population[J]. Environ Health Perspect, 2003, 111(2): 201-205.
[15] Perera FP, Rauh V, Whyatt RM, et al. A summary of recent findings on birth outcomes and developmental effects of prenatal ETS, PAH, and pesticide exposures[J]. Neurotoxicology, 2005, 26(4): 573-587.
[16] Herbstman JB, Tang D, Zhu D, et al. Prenatal exposure to polycyclic aromatic hydrocarbons, benzo[a] pyrene-DNA adducts, and genomic DNA methylation in cord blood[J]. Environ Health Perspect, 2012, 120(5): 733-738.
[17] Pereira RD, De Long NE, Wang RC, et al. Angiogenesis in the placenta: the role of reactive oxygen species signaling[J]. Biomed Res Int, 2015, 2015(8): 814543. doi: 10.1155/2015/814543. Epub 2015 Jan 29. Review.
[18] Lee J, Kalia V, Perera F, et al. Prenatal airborne polycyclic aromatic hydrocarbon exposure, LINE1 methylation and child development in a Chinese cohort[J]. Environ Int, 2017, 99: 315-320.
[19] Saunders CR, Das SK, Ramesh A, et al. Benzo(a)pyrene-induced acute neurotoxicity in the F-344 rat: role of oxidative stress[J]. J Appl Toxicol, 2006, 26(5): 427-438.
[20] Block ML, Calderón-Garcidueñas L. Air pollution: mechanisms of neuroinflammation and CNS disease[J]. Trends Neurosci, 2009, 32(9): 506-516.
[21] Perera F, Phillips DH, Wang Y, et al. Prenatal exposure to polycyclic aromatic hydrocarbons/aromatics, BDNF and child development[J]. Environ Res, 2015, 142(3): 602-608.
[22] Brown LA, Khousbouei H, Goodwin JS, et al. Down-regulation of early ionotrophic glutamate receptor subunit developmental expression as a mechanism for observed plasticity deficits following gestational exposure to benzo(a)pyrene[J]. Neurotoxicology, 2007, 28(5): 965-978.
[23] Dutta K, Ghosh D, Nazmi A, et al. A common carcinogen benzo[a] pyrene causes neuronal death in mouse via microglial activation[J]. PLoS One, 2010, 5(4): e9984. doi: 10.1371/journal.pone.0009984.
[24] Dejmek J, Solanský I, Benes I, et al. The impact of polycyclic aromatic hydrocarbons and fine particles on pregnancy outcome[J]. Environ Health Perspect, 2000, 108(12): 1159-1164.
[1] ZHENG Su, CHEN Shuhua, LI Hua, DENG Jie, CHEN Chunhong, WANG Xiaohui, FENG Weixing, HAN Xiaodi, ZHANG Yujia, LI Na, LI Mo, FANG Fang. Correlation between EEG variations and BASED evaluation of the efficacy of ACTH treatment in 54 cases of infantile spasms [J]. Journal of Shandong University (Health Sciences), 2022, 60(9): 91-96.
[2] ZHAO Haiqing, LI Baomin, YANG Xiaofan, ZHANG Tong, LI Jun, ZHAO Yongheng, GAO Liang. Acute intermittent porphyria with infantile spasm: a case report and literature review [J]. Journal of Shandong University (Health Sciences), 2022, 60(6): 82-89.
[3] Yanyan MA,Yaoqin GONG. Application of brain organoids in investigating neurodevelopmental diseases [J]. Journal of Shandong University (Health Sciences), 2021, 59(9): 22-29.
[4] MA Xue, WANG Fengxue, ZHANG Shule, LI Guimei. Clinical characteristics of 9 cases of pituitary stalk interruption syndrome in infants with intractable hypoglycemia as the primary manifestation [J]. Journal of Shandong University (Health Sciences), 2021, 59(2): 60-65.
[5] CAO Meng, WANG Liheng, PENG Xiumiao, CUI Liangliang. Concentration characteristics and chronic health risk assessment of polycyclic aromatic hydrocarbons in atmospheric PM2.5 in two districts of Jinan from 2016 to 2020 [J]. Journal of Shandong University (Health Sciences), 2021, 59(12): 87-95.
[6] YANG Haixia, CHENG Kai, HOU Qian, ZHANG Min, SUN Ming, ZHANG Linna. Retrospective analysis of eye disease screening for 0-6 years old infants in Jinan City during 2015 and 2017 [J]. Journal of Shandong University (Health Sciences), 2018, 56(9): 41-46.
[7] QIU Jie, ZANG Lijiao, ZHUANG Genmiao, AN Li. Correlation between multiorgan damage and perinatal asphyxia occurred at different gestational ages [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(9): 64-68.
[8] PAN Yanyan, SUN Yongchao, ZHAO Cuifen, KONG Qingyu. Clinical efficacy of bosentan in the treatment of babies with congenital heart disease complicated with pulmonary hypertension [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(2): 53-56.
[9] WU Yiliang, ZHANG Linfeng, LI Yuan, LIU Xiaowen, XU Guangqi, GAO Feng, LÜ Renrong, HUO Ran. Ultra-high-frequency ultrasound vs high-frequency ultrasound in assessing superficial infantile hemangioma [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(12): 72-76.
[10] CI Chun-yan, LI Wen, LU Xian-mei . Analysis of amplitude integrated electroencephalography
characteristics in preterm infants [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2012, 50(9): 109-112.
[11] LONG Xin-xin, WANG Xue-yu. Clinical effect and follow-up analysis of lowdose adrenocorticotropic
hormone for infantile spasms [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2012, 50(5): 88-91.
[12] YANG Xueyong1, ZHOU Gengxu1, LI Qiuping2, FU Song1, LIU Yuhang1, WANG Hui1, ZHAO Xin2, FENG Zhichun3 . Bedside surgical ligation of patent ductus arteriosus in  low body weight premature infants [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2011, 49(8): 133-135.
[13] YU Haili, WANG Xueyu, XI Jiashui, SUN Wenxiu. A comparative study on the efficacy and adverse reactions of two different dosages of  adrenocorticotropic hormone therapy for infantile spasms [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2010, 48(2): 100-104.
[14] . Audiological features of auditory steadystate response and auditory brain stem response in large vestibular aqueduct syndrome [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2009, 47(8): 89-92.
[15] ZHANG Ai-Hua, YANG Da-Kuan. Continuous ultrafiltration during cardiopulmonary bypass in infants [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2009, 47(5): 99-101.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Copyright 2018 © Editorial office of Journal of Shandong University (Health Sciences)
Supported by Beijing Magtech Co.Ltd