Journal of Shandong University (Health Sciences) ›› 2018, Vol. 56 ›› Issue (11): 111-115.doi: 10.6040/j.issn.1671-7554.0.2018.780

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Effects of polycyclic aromatic hydrocarbons exposure during pregnancy on the development of infant in Qingdao City, China

CUI Jing1, SUN Zhitao1, XIE Meng2, ZHANG Qian3, WANG Bingling1, GAO Ruqin1   

  1. 1. Qingdao Municipal Center for Disease Control and Prevention, Qingdao Institute of Preventive Medicine, Qingdao 266033, Shandong, China;
    2. Division of Expanded Immunization Program, Shandong Center for Disease Control and Prevention, Jinan 250014, Shandong, China;
    3. Maternal and Child Health Care of Family Planning Service Center of Huangdao District, Qingdao 266000, Shandong, China
  • Published:2022-09-27

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Abstract: Objective To explore the effects of polycyclic aromatic hydrocarbons(PAHs)exposure during pregnancy on the development of infants aged 6 and 12 months in a birth cohort in Qingdao City. Methods A total of 348 infants born during Jan. and Dec. 2014 were enrolled in this analysis. PAH-DNA adduct of umbilical cord blood was determined, and development quotients(DQs)were measured at the ages of 6 and 12 months with Gesell Development Inventory. The correlation between PAH-DNA adduct and DQs at the ages of 6 and 12 months was assessed with Spearman correlation analysis. The effects of PAH-DNA adduct on the DQs at the age of 12 months was evaluated with linear regression models. Results The detection rate of PAH-DAN adduct was 52.4%. The DQs of 5 functional areas ranged from 66 to 118 at the age of 6 months, and ranged from 72 to 156 at the age of 12 months. Spearman correlation 山 东 大 学 学 报 (医 学 版)56卷11期 -崔静,等.青岛人群孕期多环芳烃暴露对婴幼儿发育的影响 \=-analysis showed that the PAH-DNA adduct levels were negatively correlated with the DQs of gross motor(r=0.188), fine motor(r=0.196), and personal social behavior(r=0.180)at the age of 12 months, and the differences were statistically significant(P<0.05). After the gender of infants, age of pregnant woman, birth weight, and educational levels of pregnant woman were adjusted, the PAH-DNA adduct levels were negatively correlated with the DQs of adaptive, gross motor, fine motor, language, and personal social behavior at the age of 12 months(P<0.05). Conclusion PAHs exposure during pregnancy may have adverse effects on the development of 12-month-old infants. Reducing PAHs exposure has certain preventive effects on the early developmental damage in infants.

Key words: Polycyclic aromatic hydrocarbons, Neurodevelopment, Infant, PAH-DNA adduct

CLC Number: 

  • R114
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