Journal of Shandong University (Health Sciences) ›› 2018, Vol. 56 ›› Issue (5): 13-17.doi: 10.6040/j.issn.1671-7554.0.2018.220

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Prognostic factors for oncology and fertility outcomes of early stage epithelial ovarian cancer patients who accepted fertility-sparing surgery

ZHANG Ying1, YANG Jiaxin1, CAO Dongyan1, YU Mei1, SHEN Keng1, HUANG Huifang1, PAN Lingya1, WU Ming1, LANG Jinghe1, YOU Yan2   

  1. 1. Department of Obstetrics and Gynecology;
    2. Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Science &
    Peking Union Medical College, Beijing 100730, China
  • Received:2018-02-12 Published:2022-09-27

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Abstract: Objective To investigate the influencing factors of tumor and fertility prognosis for patients with early stage epithelial ovarian cancer(EOC)who accepted fertility-sparing surgery(FSS). Methods A retrospective study was done on the clinical data of 38 patients with EOC who had undergone FSS to assess the influencing factors such as age, surgery, pathological type, histological grade, clinical stage, or chemotherapy after the surgery, on the clinical and fertility outcomes. Results The median time of follow-up was 90.5 months. The 5-year overall survival(OS)rate and 5-year progression-free survival(PFS)rate was 97% and 80%, respectively, while the rate of relapse was 28.9%. Only grade G2/G3 influenced PFS significantly(χ2=39.36, P<0.001). No significant difference was found between stage ⅠA and ⅠC1/ⅠC2(P>0.05). The conception rate was 62.5%, and 40.6% of the patients had live birth. Fertility outcomes were not influenced by age, surgery, FIGO stage, chemotherapy or relapse. Conclusion Conservative treatment for early EOC patients can be performed reasonably because of the good outcomes of tumor and fertility prognosis. Histological grade is risk factor that should be considered for the patients’ treatment.

Key words: Epithelial ovarian cancer, Fertility-sparing, Surgery, Prognosis factors, Fertility outcome

CLC Number: 

  • R737.31
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