Journal of Shandong University (Health Sciences) ›› 2018, Vol. 56 ›› Issue (4): 18-22.doi: 10.6040/j.issn.1671-7554.0.2018.206

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Advance in genetic study on oocyte maturation failure

XIAO Hongmei   

  1. Institute of Reproduction and Stem Cell Engineering, School of Basic Medicine Science, Central South University, Changsha 410078, Hunan, China
  • Published:2022-09-27

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Abstract: Oocyte maturation has undergone a series of complex physiological changes and molecular regulation processes, such as meiosis resumption, germinal vesicle breakdown and expulsion of first polar body to acquire the potential of fertilization and development into a new individual. Oocytes cannot mature and be fertilized when the procedure above is impeded for various reasons, thus lead to human infertility. With the wide application of the second generation sequencing technology, the research of genetic etiology of developmental disorder and maturation arrest of human oocyte has 山 东 大 学 学 报 (医 学 版)56卷4期 -肖红梅. 卵母细胞成熟障碍研究进展 \=-made a breakthrough: several causal mutations of different genes leading to human oocyte maturation arrest have been identified recently. The methods and ideas of these researches are helpful to deepen the study of the genetic and molecular mechanisms of human oocyte maturation failure.

Key words: Oocyte maturation failure, Infertility, Meiosis, Whole exome sequencing, Gene mutation

CLC Number: 

  • R310.27
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