Journal of Shandong University (Health Sciences) ›› 2019, Vol. 57 ›› Issue (1): 36-40.doi: 10.6040/j.issn.1671-7554.0.2018.1316

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Significance of 99mTc-PSMA SPECT/CT guided salvage lymph node dissection for prostate cancer patients with biochemical recurrence

SU Hengchuan1, ZHU Yao1, DAI Bo1, LIU Chang2, HU Silong2, YE Dingwei1   

  1. 1. Department of Urology, Shanghai Cancer Center of Fudan University, Shanghai Medical College, Fudan University, Shanghai 200032, China;
    2. Department of Nuclear Medicine, Shanghai Cancer Center of Fudan University, Shanghai 200032, China
  • Published:2022-09-27

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Abstract: Objective To improve the value of salvage lymph node dissection for patients treated with radical prostatectomy(RP)with biochemical recurrence. Methods The clinical data of 3 typical cases treated with 99mTc-prostate-specific membrane antigen(PSMA)single photon emission computed tomography(SPECT)/CT guided salvage lymph node dissection during 2015 and 2017 were retrospectively analyzed. Results In case 1, the prostate specific antigen(PSA)control was not satisfactory after RP. PSMA SPECT/CT showed suspicious lymph node metastases near the left iliac blood vessels. After extended pelvic lymphadenectomy, the PSA level decreased to 0.2 ng/mL for 8 months and then increased again. In case 2, the PSA level increased to 22 ng/mL after RP. PSMA SPECT/CT showed suspicious retroperitoneal lymph node metastases. After retroperitoneal salvage lymph node dissection, the PSA level decreased to 10 ng/mL in 3 months and then bounced back. In case 3, after radical radiation, the PSA level gradually decreased and 山 东 大 学 学 报 (医 学 版)57卷1期 -宿恒川,等.PSMA SPECT/CT检查引导下的挽救性淋巴结清扫术在生化复发前列腺癌患者治疗中的价值 \=-then increased to 4 ng/mL. PSMA SPECT/CT showed suspicious lymph node metastases near the right iliac blood vessels. After salvage pelvic lymph node dissection plus radiation, the PSA level decreased to less than 0.2 ng/mL for 14 months and then increased. Conclusion For prostate cancer patients with biochemical recurrence, low PSA level and isolated nodal recurrence after RP, PSMA SPECT/CT guided salvage lymph node dissection can alleviate tumor burden and benefit the patients.

Key words: Prostate-specific membrane antigen, Prostate cancer, Metastatic lesions, Salvage lymph node dissection

CLC Number: 

  • R737.25
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