Journal of Shandong University (Health Sciences) ›› 2019, Vol. 57 ›› Issue (1): 30-35.doi: 10.6040/j.issn.1671-7554.0.2018.1423

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Development of precision medicine in the treatment of castration-resistant prostate cancer

WANG Haitao   

  1. Department of Oncology, Second Hospital of Tianjin Medical University;
    Tianjin Institute of Urology, Tianjin 300211, China
  • Published:2022-09-27

Abstract: The incidence of prostate cancer in China has been increasing in recent years, and most cases have already reached the advanced stage when the diagnosis is confirmed. Although many patients are initially sensitive to androgen deprivation therapy(ADT)and experience temporary tumor regression, nearly all will develop castration-resistant prostate cancer(CRPC), which is difficult to cure and thus has poor prognosis. New therapies for CRPC remains an urgent need. The emergence of precision medicine and high-throughput sequencing of cancer genomes makes molecular typing of CRPC patients possible. This article reviews the molecular typing of prostate cancer and development of precision medicine in the treatment of CRPC.

Key words: Castration-resistant prostate cancer, Precision medicine, High-throughput sequencing, Molecular targeted therapy

CLC Number: 

  • R737.25
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