JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

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Expression of nerve growth factor precursor in pathological scars

ZHOU Yichong1, ZHANG Rui2, FENG Yongqiang1, FENG Zhang1, WANG Yibing1   

  1. 1. Department of Burn and Plastic Surgery, Shandong Provincial Hospital Affiliated to
    Shandong University, Jinan 250021, Shandong, China;
     2. Department of Pathology and Pathophysiology, Shandong Medical College, Jinan 250002, Shandong, China
  • Received:2013-10-25 Online:2014-05-10 Published:2014-05-10

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Abstract: Objective  To observe the expression of nerve growth factor precursor (proNGF) in pathological scars. Methods  A total of 23 hyperplastic scar samples and 20 keloid samples (pathological scar group) and 20 normal skin tissues (control group) were collected. The proNGF expressions were examined with immunohistochemical and Western blotting techniques. Results  The proNGF was positively expressed in all three tissue types, especially in epidermal cells and fibroblasts. Immunohistochemical examination indicated that proNGF expression was significantly lower in hyperplastic scars and keloids than in normal skin (χ2=8.23, P<0.05; χ2=8.29, P <0.05). Western blotting showed that protein expression of proNGF was markedly lower in hyperplastic scars and keloids than in normal skin (t=14.02, P<0.01; t=20.80, P<0.01). Conclusion  Compared with normal skin, proNGF expression in pathological scars is significantly lower, suggesting the negative relationship between proNGF expression and scar proliferation.

Key words: Nerve growth factor precursor, Pathological scar, Fibroblast, Skin

CLC Number: 

  • R364.3
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