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山东大学学报 (医学版) ›› 2024, Vol. 62 ›› Issue (1): 63-70.doi: 10.6040/j.issn.1671-7554.0.2023.0694

• 临床医学 • 上一篇    

国产体外膜肺氧合治疗急性呼吸循环衰竭8例并文献复习

李瑞建1,张建波1,边圆1,刘淑琴2,刘艳伟3   

  • 发布日期:2024-02-02
  • 通讯作者: 刘淑琴. E-mail:lshuqin@sdu.edu.cn
  • 基金资助:
    山东大学临床研究中心急危重症重点专项经费支持(23460047102116)

Domestic extracorporeal membrane oxygenation in the treatment of cardiogenic shock and acute respiratory failure: a report of 8 cases and literature review

LI Ruijian1, ZHANG Jianbo1, BIAN Yuan1, LIU Shuqin2, LIU Yanwei3   

  1. 1. Department of Emergency, Qilu Hospital, Shandong University, Jinan 250012, Shandong, China;
    2. School of Electrical Engineering, Shandong University, Jinan 250061, Shandong, China;
    3. Shandong Hengxin Medical Equipment Co., Ltd., Jinan 250061, Shandong, China
  • Published:2024-02-02

摘要: 目的 探讨应用国产体外膜肺氧合设备(HX-ECMO)救治急性呼吸循环衰竭患者的安全性及临床效果。 方法 2022年12月至2023年3月山东大学齐鲁医院急诊科使用HX-ECMO治疗急性呼吸循环衰竭患者8例。对施行ECMO辅助治疗的效果进行前瞻性分析。 结果 8例急性呼吸循环衰竭患者经ECMO治疗后的各项指标优于治疗前,通过离心泵和膜肺给机体提供充足的血液及氧气供应,为器官功能恢复创造了条件。相对于常规治疗方案,ECMO的应用提高了急性呼吸循环衰竭患者救治成功率。研究期间HX-ECMO运转稳定,性能良好。 结论 国产HX-ECMO性能良好,提高急性呼吸循环衰竭患者救治成功率,为ECMO技术推广应用提供有力支持。

关键词: 体外膜肺氧合, 急性呼吸循环衰竭, 离心泵, 膜肺, 心肺功能

Abstract: Objective To analyze the safety and efficacy of domestic extracorporeal membrane oxygenation(HX-ECMO)for patients with cardiogenic shock and acute respiratory failure. Methods In the Department of Emergency, Qilu Hospital, Shandong University, HX-ECMO was used for the treatment of 8 patients with cardiogenic shock and(or)acute respiratory failure during December 2022 and March 2023. The efficacy of treatment was prospectively analyzed. Results After treatment, all indexes were improved, as sufficient circulatory and oxygenation support were provided to patients through artificial heart pump and membrane lung, which created conditions for the recovery of organ function. Compared with conventional treatment, ECMO improved the success rate of acute respiratory and circulatory failure. During the study, HX-ECMO operated stably and performed well. Conclusion Domestic HX-ECMO can effectively improve the success rate of patients with cardiogenic shock and acute respiratory failure, which can provide support for the application of ECMO.

Key words: Extracorporeal membrane oxygenation, Cardiogenic shock, Centrifugal pump, Membrane oxygenator, Cardiopulmonary function

中图分类号: 

  • R563.8
[1] Combes A, Price S, Slutsky AS, et al. Temporary circulatory support for cardiogenic shock[J]. Lancet, 2020, 396(10245): 199-212.
[2] Eftychiou S, Kalakoutas A, Proudfoot A. The role of temporary mechanical circulatory support in de novo heart failure syndromes with cardiogenic shock: a contemporary review[J]. J Intensive Med, 2022, 3(2): 89-103.
[3] Quintel M, Bartlett RH, Grocott MPW, et al. Extracorporeal membrane oxygenation for respiratory failure[J]. Anesthesiology, 2020, 132(5): 1257-1276.
[4] 陈春艳, 刘小军, 祁绍艳, 等. 体外膜肺氧合在重症患者中的应用36例回顾分析[J]. 山东大学学报(医学版), 2016, 54(11): 40-43. CHEN Chunyan, LIU Xiaojun, QI Shaoyan, et al. Retrospective analysis of 36 critical patients treated by extracorporeal menlbrarle oxygenation[J]. Journal of Shandong University(Health Sciences), 2016, 54(11): 40-43.
[5] Rao P, Khalpey Z, Smith R, et al. Venoarterial extracorporeal membrane oxygenation for cardiogenic shock and cardiac arrest[J]. Circ Heart Fail, 2018, 11(9): e004905. doi:10.1161/circheartfailure.118.004905.
[6] Wheeler CR, Bullock KJ. Extracorporeal membrane oxygenation: 2022 year in review[J]. Respir Care,2023,4:10929. doi: 10.4187/respcare.10929.
[7] McNamee JJ, Gillies MA, Barrett NA, et al. Effect of lower tidal volume ventilation facilitated by extracorporeal carbon dioxide removal vs standard care ventilation on 90-day mortality in patients with acute hypoxemic respiratory failure: the REST randomized clinical trial[J]. JAMA, 2021, 326(11): 1013-1023.
[8] Abrams D, MacLaren G, Lorusso R, et al. Extracorporeal cardiopulmonary resuscitation in adults: evidence and implications[J]. Intensive Care Med, 2022, 48(1): 1-15.
[9] 霍兴兰. 无创呼吸机治疗呼吸衰竭84例的临床观察[J]. 山东大学学报(医学版), 2014, 52(S2): 50, 54.
[10] Arachchillage DJ, Weatherill A, Rajakaruna I, et al. Thombosis, major bleeding, and survival in COVID-19 supported by veno-venous extracorporeal membrane oxygenation in the first vs second wave: a multicenter observational study in the United Kingdom[J]. J Thromb Haemost, 2023, 21(10): 2735-2746.
[11] Giraud R, Legouis D, Assouline B, et al. Timing of VV-ECMO therapy implementation influences prognosis of COVID-19 patients[J]. Physiol Rep, 2021, 9(3): e14715. doi:10.14814/phy2.14715.
[12] Steimer DA, Hernandez O, Mason DP, et al. Timing of ECMO initiation impacts survival in influenza-associated ARDS[J]. Thorac Cardiovasc Surg, 2019, 67(3): 212-215.
[13] 黎嘉嘉, 罗小秀, 黄晓波. 静脉-动脉体外膜肺氧合上机时机的探讨[J]. 中华医学杂志, 2022, 102(25):1874-1877. LI Jiajia, LUO Xiaoxiu, HUANG Xiaobo. Initiation timing of veno-arterial extracorporeal membrane oxygenation[J]. National Medical Journal of China, 2022, 102(25):1874-1877.
[14] Tonna JE, Abrams D, Brodie D, et al. Management of adult patients supported with venovenous extracorporeal membrane oxygenation(VV ECMO): guideline from the extracorporeal life support organization(ELSO)[J]. ASAIO J, 2021, 67(6): 601-610.
[15] Sud S, Friedrich JO, Adhikari NKJ, et al. Comparative effectiveness of protective ventilation strategies for moderate and severe acute respiratory distress syndrome. A network meta-analysis[J]. Am J Respir Crit Care Med, 2021, 203(11): 1366-1377.
[16] Danial P, Olivier ME, Bréchot N, et al. Association between shock etiology and 5-year outcomes after venoarterial extracorporeal membrane oxygenation[J]. J Am Coll Cardiol, 2023, 81(9): 897-909.
[17] 朱清一, 金啸天, 漆能华, 等. 静脉-动脉体外膜肺氧合治疗相关并发症回顾性分析[J]. 中华心力衰竭和心肌病杂志, 2022, 6(2): 127-133. ZHU Qingyi, JIN Xiaotian, QI Nenghua, et al. Single-center retrospective analysis of complications related to venoarterial extracorporeal membrane oxygenation[J]. Chinese Journal of Heart Failure and Cardiomyopathy, 2022, 6(2): 127-133.
[18] 刘淑琴,边忠国,李瑞建,等. 磁悬浮人工心脏泵及其在体外循环系统上的试验研究[J]. 西南交通大学学报,2023, 58(4): 820-826. LIU Shuqin, BIAN Zhongguo, Ll Ruijian, et al. Maglev Artificial Heart Pump and Experimental Study on ECMO[J]. Journal of Southwest JiaoTong University, 2023, 58(4): 820-826.
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[2] 陈春艳,刘小军,祁绍艳,王文涛. 体外膜肺氧合在重症患者中的应用36例回顾分析[J]. 山东大学学报(医学版), 2016, 54(11): 40-43.
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