您的位置:山东大学 -> 科技期刊社 -> 《山东大学学报(医学版)》

山东大学学报 (医学版) ›› 2021, Vol. 59 ›› Issue (6): 76-80.doi: 10.6040/j.issn.1671-7554.0.2021.0328

• 临床医学 • 上一篇    下一篇

25例早期宫颈癌无瘤化免举宫腹腔镜子宫切除术临床效果

王璐,赵新蕊,朱琳   

  1. 山东大学第二医院妇科, 山东 济南 250033
  • 发布日期:2021-06-10
  • 通讯作者: 朱琳. E-mail:zl-emtf@163.com

Clinical efficacy of laparoscopic radical hysterectomy without lift and tumor spillage in 25 cases of early-stage cervical cancer

WANG Lu, ZHAO Xinrui, ZHU Lin   

  1. Department of Gynecology, The Second Hospital of Shandong University, Jinan 250033, China
  • Published:2021-06-10

摘要: 目的 探讨早期宫颈癌无瘤化免举宫腹腔镜子宫切除手术方式的可行性及临床效果。 方法 选择2020年3月至2021年1月于山东大学第二医院接受无瘤化免举宫腹腔镜子宫切除术的25例早期宫颈癌患者为研究对象。术中通过经阴道封闭瘤体、淋巴结清扫后立即装袋隔离、牵拉缝线代替举宫器、阴道末端环扎及闭合、子宫切除后立即装袋隔离,确保手术的免举宫及无瘤化原则。 结果 25例早期宫颈癌患者均顺利完成无瘤化免举宫腹腔镜子宫切除术,无中转开腹及输尿管、肠管损伤。平均手术时间(205.3±18.7)min,平均术中出血量(79.28±20.16)mL。左、右侧宫旁组织切除宽度分别为(2.8±0.6)cm、(2.9±0.4)cm,主韧带切除长度(2.9±0.35)cm,宫骶韧带切除长度(3.18±0.36)cm,阴道切除长度(3.2±0.21)cm。盆腔淋巴结清扫数目(22.5±4.3)枚。术后病理结果显示均无淋巴结转移,宫旁切缘及阴道切缘均为阴性。术后平均排气时间(34.18±8.67)h,术后拔出尿管时间(11.05±3.67)d。 结论 该手术方式安全可行,既保证了足够的手术切除范围,又最大程度上确保了手术过程中的无瘤化原则。

关键词: 宫颈癌, 腹腔镜, 免举宫, 无瘤化, 子宫切除

Abstract: Objective To explore the feasibility and clinical efficacy of laparoscopic hysterectomy without lift and tumor spillage for cervical cancer at early stage. Methods A total of 25 patients with cervical cancer who received laparoscopic hysterectomy without lift and tumor spillage at The Second Hospital of Shandong University during Mar. 2020 and Jan. 2021 were enrolled. During the surgery, the neoplasia was sealed via the vagina. The lymph nodes were bagged immediately after dissection, sutures were pulled to lift the uterus, the vaginal end was ligated and occluded, and the uterus was bagged immediately after hysterectomy to ensure no tumor spillage. Results All 25 patients successfully completed laparoscopic hysterectomy without conversion to open surgery, and there were no ureteral or intestinal injuries. The average operation time was(205.3±18.7)min, and average intraoperative bleeding volume was(79.28±20.16)mL. The widths of the excised left and right parauterine tissues were(2.8±0.6)cm and(2.9±0.4)cm, respectively. The lengths of excised main ligament, uterosacral ligament and vagina were(2.9±0.35)cm,(3.18±0.36)cm, and(3.2±0.21)cm, respectively. The number of dissected pelvic lymph nodes was(22.5±4.3). No lymph node metastasis was observed. The margins of hysterectomy and vaginectomy were negative. The mean time of postoperative ventilation was(34.18±8.67)h, and the catheter removal time was(11.05±3.67)d. Conclusion This surgical approach is safe and feasible, which ensures not only enough resection range, but also no tumor spillage during operation.

Key words: Cervical carcinoma, Laparoscope, Without lift, Non-tumor spillage, Hysterectomy

中图分类号: 

  • R737.33
[1] Brotherton JM, Fridman M, May CL, et al. Early effect of the HPV vaccination programme on cervical abnormalities in Victoria, Australia: an ecological study [J]. Lancet, 2011, 377(9783): 2085-2092.
[2] 王宇, 宋淑芳, 刘凤. 我国宫颈癌流行病学特征和发病高危因素的研究进展[J]. 中国妇幼保健, 2019, 34(5): 1206-1208.
[3] Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries [J]. CA Cancer J Clin, 2018, 68(6): 394-424.
[4] Lei J, Ploner A, Elfström KM, et al. HPV vaccination and the risk of invasive cervical cancer [J]. N Engl J Med, 2020, 383(14): 1340-1348.
[5] Tewari KS, Monk BJ. Evidence-based treatment paradigms for management of invasive cervical carcinoma [J]. J Clin Oncol, 2019, 37(27): 2472-2489.
[6] Brucker SY, Ulrich UA. Surgical treatment of early-stage cervical cancer [J]. Oncol Res Treat, 2016, 39(9): 508-514.
[7] Chang WC, Lee LC, Huang SC, et al. Application of laparoscopic surgery in gynecological oncology [J]. J Formos Med Assoc, 2010, 109(8): 558-566.
[8] Melamed A, Margul DJ, Chen L, et al. Survival after minimally invasive radical hysterectomy for early-stage cervical cancer [J]. N Engl J Med, 2018, 379(20): 1905-1914.
[9] Ramirez PT, Frumovitz M, Pareja R, et al. Minimally invasive versus abdominal radical hysterectomy for cervical cancer [J]. N Engl J Medc, 2018, c379(20): 1895-1904.
[10] Matsuo K, Chen L, Mandelbaum RS, et al. Trachelectomy for reproductive-aged women with early-stage cervical cancer: minimally-invasive surgery versus laparotomy [J]. Am J Obstet Gynecol, 2019, 220(5): 469.e1-469.e13.
[11] Tewari KS. Minimally invasive surgery for early-stage cervical carcinoma: interpreting the laparoscopic approach to cervical cancer trial results [J]. J Clin Oncol, 2019, 37(33): 3075-3080.
[12] Matsuo K, Shimada M, Yamaguchi S, et al. Association of radical hysterectomy surgical volume and survival for Early-Stage Cervical Cancer [J]. Obstet Gynecol, 2019 133(6): 1086-1098.
[13] Alfonso Dueas-González, Campbell S. Global strategies for the treatment of early-stage and advanced cervical cancer [J]. Curr Opin Obstet Gynecol, 2016, 28(1): 11-17.
[14] Pathiraja P, Tozzi R. Advances in gynaecological oncology surgery [J]. Best Pract Res Clin Obstet Gynaecol, 2013, 27(3): 415-420.
[15] Li X, Li J, Jiang Z, et al. Oncological results and recurrent risk factors following abdominal radical trachelectomy(ART): An updated series of 333 patients [J]. BJOG, 2019, 126(9): 1169-1174.
[16] Karam A, Dorigo O. Minimally invasive surgery for gynecologic cancers-a cautionary tale [J]. JAMA Oncol, 2020, 6(7): 991-993.
[17] 熊光武, 张国楠. 对早期宫颈癌腹腔镜与开腹手术远期疗效差异的思考[J]. 中国微创外科杂志, 2019, 19(1): 1-3.
[18] Choi CH, Lee JY, Lee YY, et al. Comparison of laparoscopic-assisted radical vaginal hysterectomy and laparoscopic radical hysterectomy in the treatment of cervical cancer [J]. Ann Surg Oncol, 2012, 19(12): 3839-3848.
[19] Lago V, Tiermes M, Padilla-Iserte P, et al. Protective maneuver to avoid tumor spillage during laparoscopic radical hysterectomy: vaginal cuff closure [J]. J Minim Invasive Gynecol, 2021, 28(2): 174-175.
[20] Yang Y, Liu Y, Li G, et al. Vaginal stump ligation for cervical cancer [J]. Iran J Public Health, 2017, 46(10): 1332-1337.
[21] Wiebren AA, Tjalma. The survival after a radical hysterectomy for cervical cancer by open surgery is significantly better than after minimal invasive surgery: evidence beats gut feeling! [J]. Eur J Obstet Gynecol Reprod Biol, 2018, 229: 195-197. doi: 10.1016/j.ejogrb.2018.07.027.
[22] Ferrandina G, Corrado G, Scambia G. Minimally invasive surgery and quality of life in cervical cancer [J]. Lancet Oncol, 2020, 21(6): 746-748.
[23] Martino MA, Bixel K, Msiv A, et al. A novel technique to minimize contamination for cervical cancer surgery patients [J]. J Minim Invasive Gynecol, 2020, 27(7): 1624-1630.
[24] Boyraz G, Karalok A, Basaran D, et al. Vaginal closure with endoGIA to prevent tumor spillage in laparoscopic radical hysterectomy for cervical cancer [J]. J Minim Invasive Gynecol, 2019, 26(4): 602. doi: 10.1016/j.jmig.2018.07.015.
[25] Ramirez PT. Quality indicators in cervical cancer surgery: a valiant step in the right direction [J]. Int J Gynecol Cancer, 2020, 30(1): 1-2.
[26] Gaffney DK. Optimal therapy for IB2 and IIA2 cervical cancer: surgery or chemoradiotherapy? [J]. J Gynecol Oncol, 2012, 23(4): 207-209.
[27] Melamed A, Rauh-Hain JA, Ramirez PT. Minimally invasive radical hysterectomy for cervical cancer: when adoption of a novel treatment precedes prospective, randomized evidence [J]. J Clin Oncol, 2019, 37(33): 3069-3074.
[1] 薛莹,周兴国,王宇,王德海,丁印鲁. 左侧巨大十二指肠旁疝1例报道[J]. 山东大学学报 (医学版), 2022, 60(8): 127-129.
[2] 张信美,徐萍. 子宫腺肌病的手术治疗策略[J]. 山东大学学报 (医学版), 2022, 60(7): 26-31.
[3] 李博,刘竞芳,鲍金鹏,李祥泽,秦广洋,田虎. 三维可视化联合吲哚菁绿荧光影像技术在51例原发性肝癌腹腔镜切除术中的应用价值[J]. 山东大学学报 (医学版), 2022, 60(3): 83-88.
[4] 修德健,高正文,宋婷婷,崔楠,崔静,孙健平. 生物信息学方法分析与宫颈癌有关联的基因[J]. 山东大学学报 (医学版), 2022, 60(10): 99-109.
[5] 陈泉材,韩赛,刘露,孙雨,尤学武,张俊华,张友忠. CDC7、MCM4在105例宫颈病变组织中的表达及意义[J]. 山东大学学报 (医学版), 2022, 60(1): 34-39.
[6] 仲明惟,胡三元. 我国腹腔镜技术治疗肥胖症手术方式的探索[J]. 山东大学学报 (医学版), 2021, 59(9): 72-77, 96.
[7] 梁婷婷,杨勇霞,侯丛哲,黄太胜,王华丽,朱琳. PAX1基因甲基化与宫颈高级别上皮内病变及高危型HPV分型的关联性[J]. 山东大学学报 (医学版), 2021, 59(11): 48-52.
[8] 霍素霞,刘薇,王鑫. 86例Ⅲ型瘢痕妊娠诊治体会[J]. 山东大学学报 (医学版), 2021, 59(1): 40-44.
[9] 刘超,闫动,李香,张蕾,李燕. 腹腔镜辅助经脐小切口治疗小儿美克尔憩室的临床分析[J]. 山东大学学报 (医学版), 2020, 1(9): 40-44.
[10] 张召义,韩婷,孙艳萍,李波. 聚乙二醇电解质散在40例妇科腹腔镜术前肠道准备中的应用[J]. 山东大学学报 (医学版), 2020, 58(2): 49-53.
[11] 王波,熊颖,倪志福,屈振繁. 加速康复外科理念在1~3岁日间疝手术中的应用[J]. 山东大学学报 (医学版), 2020, 58(12): 92-96.
[12] 张照鹏,邢乃栋,张翔,阎磊,徐忠华. 160例腹腔镜根治性膀胱切除术后淋巴漏的影响因素分析[J]. 山东大学学报 (医学版), 2020, 58(1): 67-72.
[13] 董昌正,周伟,李风周,臧义丰,丁印鲁. 全腹腔镜下全胃+胆囊+阑尾切除经自然腔道取标本手术1例[J]. 山东大学学报 (医学版), 2019, 57(7): 122-124.
[14] 关小明,张意茗,范晓东. 单孔腹腔镜技术的发展及展望[J]. 山东大学学报 (医学版), 2019, 57(12): 5-9.
[15] 华克勤,李珺玮,陈义松. 单孔腹腔镜在盆底功能障碍中的应用[J]. 山东大学学报 (医学版), 2019, 57(12): 10-14.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
[1] 郑敏,郝跃伟,刘雪平,赵婷婷. 血小板膜糖蛋白Ibα基因HPA-2、Kozak序列多态性与脑梗死的相关性研究[J]. 山东大学学报(医学版), 2008, 46(3): 292 -295 .
[2] 方英立,马玉燕,刘锡梅,周文 . 急诊剖宫产患者围手术期替硝唑合理应用[J]. 山东大学学报(医学版), 2007, 45(10): 995 .
[3] 姜红菊,李润智,王营,徐冬梅,张梅,张运,李继福 . 冠状动脉粥样硬化斑块形态及介入治疗与MMP-9的关系[J]. 山东大学学报(医学版), 2008, 46(10): 966 -970 .
[4] 张杰,李振华,孙晋浩,暴丽华,刘岳鹏. 恒定磁场对Schwann细胞氧化损伤的保护作用[J]. 山东大学学报(医学版), 2007, 45(3): 229 -232 .
[5] 赵鹏,毕万利,李宁 . 螺旋CT后处理技术对青少年先天性脊柱畸形的诊断价值[J]. 山东大学学报(医学版), 2007, 45(8): 825 -829 .
[6] 王术芹,齐 峰,吴剑波,孙宝柱. 罗哌卡因对大鼠离体主动脉收缩作用的钙离子调节机制[J]. 山东大学学报(医学版), 2008, 46(8): 773 -776 .
[7] 滕学仁,赵永生,胡光亮,周伦,李建民 . 两种方法保存同种异体髌腱移植重建膝关节交叉韧带的光镜电镜观察[J]. 山东大学学报(医学版), 2008, 46(10): 945 -950 .
[8] 袁吴敏,赵志伦,王洁贞 . 吸烟和饮酒与颅内肿瘤关系的Meta分析[J]. 山东大学学报(医学版), 2006, 44(11): 1146 -1149 .
[9] 李明霞,王学禹 . 儿童急性播散性脑脊髓炎31例临床与MRI特点[J]. 山东大学学报(医学版), 2008, 46(8): 828 -830 .
[10] . Graves病131治疗后1年内早发甲减影响因素分析[J]. 山东大学学报(医学版), 2009, 47(9): 5 -6 .