阿尔茨海默病诊断标准:从临床诊断到病理生理诊断

doi:10.6040/j.issn.1671-7554.0.2017.320

摘要/Abstract

摘要： 痴呆已经成为老年人群致死和致残的主要疾病之一,而阿尔茨海默病(AD)是痴呆的首要病因。AD的第一个诊断标准是1984年由美国神经语言障碍与卒中研究所和阿尔茨海默病与相关疾病协会工作组联合制订的。此后,随着对AD病理生理机制理解的逐渐深入和临床研究的需要,先后推出了两套AD的诊断标准,包括国际工作组发表于2007年、更新于2014年的IWG-1诊断标准,以及美国国立老化研究院和阿尔茨海默病协会于2011年制定的NIA-AA诊断标准。深入认识AD诊断标准的演变过程和不同诊断标准间的异同,对于理解AD的病理生理机制,更好地开展临床诊疗和科研工作有着重要意义。

关键词: 阿尔茨海默病, 诊断标准, 生物标记物, AD临床前阶段

Abstract: Alzheimers disease(AD)is the leading cause of dementia and the most prevalent neurodegenerative disease in the elderly. The first diagnostic criteria was developed by the National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimers Disease and Related Disorders Association Work Group in 1984. With the further understanding of pathophysiological mechanism underlying AD, two new sets of research criteria for Alzheimers 山东大学学报 (医学版)55卷10期 -唐毅.阿尔茨海默病诊断标准:从临床诊断到病理生理诊断 \=-disease were proposed: those published by an International Working Group in 2007, which was updated in 2014, and the recommendations published by the National Institute on Aging and the Alzheimers Association(NIA-AA)in 2011. A comparison of the criteria is needed for clinical practice and research purpose.

Key words: Alzheimers disease, Diagnostic criteria, Biomarker, Preclinical AD

中图分类号:

R741.04

唐毅. 阿尔茨海默病诊断标准:从临床诊断到病理生理诊断[J]. 山东大学学报（医学版）, 2017, 55(10): 14-20.

TANG Yi. Evolution of diagnostic criteria for Alzheimers disease: from clinical diagnosis to pathophysiological diagnosis[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(10): 14-20.

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