尿液pH与代谢综合征的相关性

doi:10.6040/j.issn.1671-7554.0.2016.307

山东大学学报（医学版） ›› 2016, Vol. 54 ›› Issue (12): 82-85.doi: 10.6040/j.issn.1671-7554.0.2016.307

尿液pH与代谢综合征的相关性

许艺博¹,季晓康²,李向一¹,申振伟¹,薛付忠¹

山东大学公共卫生学院 1.生物统计学系, 2.信息数据处理实验室, 山东济南 250012

收稿日期:2016-03-22 出版日期:2016-12-10 发布日期:2016-12-10
通讯作者: 薛付忠. E-mail:xuefzh@sdu.edu.cn E-mail:xuefzh@sdu.edu.cn
基金资助:
山东省科技发展计划(2014GSF118119)

Analysis on the relationship between urine pH and metabolic syndrome

XU Yibo¹, JI Xiaokang², LI Xiangyi¹, SHEN Zhenwei¹, XUE Fuzhong¹

1. Department of Epidemiology and Biostatistics, 2. Information and Data Analysis Lab, School of Public Health, Shandong University, Jinan, 250012, Shandong, China

Received:2016-03-22 Online:2016-12-10 Published:2016-12-10

摘要/Abstract

摘要： 目的探讨尿液pH与代谢综合征(MetS)的关系。方法以8 720名在山东大学附属省立医院健康查体中心健康体检者建立纵向队列,使用Cox比例风险模型探讨尿液pH与MetS的关系。结果经过平均3.03年随访共有1 657人发生MetS,发病密度为62.79/1 000(1 657/26 389)人·年。仅对年龄进行调整时尿液pH偏低组的风险比HR值为1.36(95%CI: 1.21~1.53, P<0.05),在此基础上对MetS的组分高血压、高血糖、血脂异常、超重进行调整后尿液pH偏低组的HR值为1.20(95%CI: 1.07~1.35, P<0.05),进一步对饮食、吸烟和饮酒因素调整后的HR值为1.17(95%CI: 1.05~1.32, P<0.05)。结论尿液pH偏低是MetS的独立危险因素。

关键词: 尿液pH, 代谢性酸中毒, Cox模型, 胰岛素抵抗, 代谢综合征

Abstract: Objective To investigate the correlation of urine pH with metabolic syndrome(MetS). Methods In this study, a longitudinal cohort with 8 720 participants was established based on the routine health check-up systems in Health Management Center of Shandong Provincial Hospital. Cox proportional-hazards model was used to detect the association between urine pH and MetS. Results 1 657 MetS occurred over an average 3.03 years follow-up, leading to a total incidence density of 62.79 per 1 000 person-years(1 657/26 389 person-years). Cox regression analysis by adjusting for age showed that hazard ratio(HR)value of lower urine pH group on MetS was1.36(95%CI: 1.21-1.53, P<0.05). After adjusting for age and four MetS components(hypertension, hyperglycemia, dyslipidemia and obesity)the HR was 1.20(95%CI: 1.07-1.35, P<0.05). After further adjusting for diet, smoking and drinking, the HR was 1.17(95%CI: 1.05-1.32, P<0.05). Conclusion Lower urine pH is an individual risk factor of MetS.

Key words: Insulin resistance, Metabolic acidosis, Cox model, Metabolic syndrome, Urine pH

中图分类号:

R181.3+8

许艺博,季晓康,李向一,申振伟,薛付忠. 尿液pH与代谢综合征的相关性[J]. 山东大学学报（医学版）, 2016, 54(12): 82-85.

XU Yibo, JI Xiaokang, LI Xiangyi, SHEN Zhenwei, XUE Fuzhong. Analysis on the relationship between urine pH and metabolic syndrome[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(12): 82-85.

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尿液pH与代谢综合征的相关性

Analysis on the relationship between urine pH and metabolic syndrome

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