尿液pH与代谢综合征的相关性

doi:10.6040/j.issn.1671-7554.0.2016.307

山东大学学报（医学版） ›› 2016, Vol. 54 ›› Issue (12): 82-85.doi: 10.6040/j.issn.1671-7554.0.2016.307

尿液pH与代谢综合征的相关性

许艺博¹,季晓康²,李向一¹,申振伟¹,薛付忠¹

山东大学公共卫生学院 1.生物统计学系, 2.信息数据处理实验室, 山东济南 250012

收稿日期:2016-03-22 出版日期:2016-12-10 发布日期:2016-12-10
通讯作者: 薛付忠. E-mail:xuefzh@sdu.edu.cn E-mail:xuefzh@sdu.edu.cn
基金资助:
山东省科技发展计划(2014GSF118119)

Analysis on the relationship between urine pH and metabolic syndrome

XU Yibo¹, JI Xiaokang², LI Xiangyi¹, SHEN Zhenwei¹, XUE Fuzhong¹

1. Department of Epidemiology and Biostatistics, 2. Information and Data Analysis Lab, School of Public Health, Shandong University, Jinan, 250012, Shandong, China

Received:2016-03-22 Online:2016-12-10 Published:2016-12-10

摘要/Abstract

摘要： 目的探讨尿液pH与代谢综合征(MetS)的关系。方法以8 720名在山东大学附属省立医院健康查体中心健康体检者建立纵向队列,使用Cox比例风险模型探讨尿液pH与MetS的关系。结果经过平均3.03年随访共有1 657人发生MetS,发病密度为62.79/1 000(1 657/26 389)人·年。仅对年龄进行调整时尿液pH偏低组的风险比HR值为1.36(95%CI: 1.21~1.53, P<0.05),在此基础上对MetS的组分高血压、高血糖、血脂异常、超重进行调整后尿液pH偏低组的HR值为1.20(95%CI: 1.07~1.35, P<0.05),进一步对饮食、吸烟和饮酒因素调整后的HR值为1.17(95%CI: 1.05~1.32, P<0.05)。结论尿液pH偏低是MetS的独立危险因素。

关键词: 尿液pH, 代谢性酸中毒, Cox模型, 胰岛素抵抗, 代谢综合征

Abstract: Objective To investigate the correlation of urine pH with metabolic syndrome(MetS). Methods In this study, a longitudinal cohort with 8 720 participants was established based on the routine health check-up systems in Health Management Center of Shandong Provincial Hospital. Cox proportional-hazards model was used to detect the association between urine pH and MetS. Results 1 657 MetS occurred over an average 3.03 years follow-up, leading to a total incidence density of 62.79 per 1 000 person-years(1 657/26 389 person-years). Cox regression analysis by adjusting for age showed that hazard ratio(HR)value of lower urine pH group on MetS was1.36(95%CI: 1.21-1.53, P<0.05). After adjusting for age and four MetS components(hypertension, hyperglycemia, dyslipidemia and obesity)the HR was 1.20(95%CI: 1.07-1.35, P<0.05). After further adjusting for diet, smoking and drinking, the HR was 1.17(95%CI: 1.05-1.32, P<0.05). Conclusion Lower urine pH is an individual risk factor of MetS.

Key words: Insulin resistance, Metabolic acidosis, Cox model, Metabolic syndrome, Urine pH

中图分类号:

R181.3+8

许艺博,季晓康,李向一,申振伟,薛付忠. 尿液pH与代谢综合征的相关性[J]. 山东大学学报（医学版）, 2016, 54(12): 82-85.

XU Yibo, JI Xiaokang, LI Xiangyi, SHEN Zhenwei, XUE Fuzhong. Analysis on the relationship between urine pH and metabolic syndrome[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(12): 82-85.

参考文献

[1] Eckel RH, Alberti KG, Grundy SM, et al. The metabolic syndrome[J]. Lancet, 2010, 375(9710):181-183.
[2] Cornier MA, Dabelea D, Hernandez TL, et al. The metabolic syndrome[J]. Endocr Rev, 2008, 29(7):777-822.
[3] Janszky I, Vatten L, Romundstad P, et al. Metabolic syndrome in Poland-the PONS study[J]. Ann Agric Environ Med, 2011, 18(2):270-272.
[4] Otsuki M, Kitamura T, Goya K, et al. Association of urine acidification with visceral obesity and the metabolic syndrome[J]. Endocr J, 2011, 58(5):363-367.
[5] Maalouf NM, Cameron MA, Moe OW, et al. Low urine pH: a novel feature of the metabolic syndrome[J]. Clin J Am Soc Nephrol, 2007, 2(5):883-888.
[6] Cho YH, Lee SY, Jeong DW, et al. The association between a low urine pH and the components of metabolic syndrome in the Korean population: findings based on the 2010 Korea national health and nutrition examination survey[J]. J Res Med Sci, 2014, 19(7):599-604.
[7] 陈颖,杨枝,黄飞,等. 尿液pH值与代谢综合征的相关性研究[J]. 内科理论与实践, 2012,7(6):448-451. CHEN Ying, YANG Zhi, HUANG Fei, et al. Correlation between urinary pH value and metabolic syndrome[J]. J Intern Med Concepts Pract, 2012, 7(6):448-451.
[8] Hara S, Tsuji H, Ohmoto Y, et al. High serum uric acid level and low urine pH as predictors of metabolic syndrome: a retrospective cohort study in a Japanese urban population[J]. Metabolism, 2012, 61(2):281-288.
[9] Williams RS, Kozan P, Samocha-Bonet D. The role of dietary acid load and mild metabolic acidosis in insulin resistance in humans[J]. Biochimie, 2016, 124:171-177. doi:10.1016/j.biochi.2015.09.012.
[10] 中华医学会糖尿病学分会代谢综合征研究协作组. 中华医学会糖尿病学分会关于代谢综合征的建议[J]. 中华糖尿病杂志, 2004(3):5-10.
[11] Alberti KG, Zimmet P, Shaw J. The metabolic syndrome-a new worldwide definition[J]. Lancet, 2005, 366(9491):1059-1062.
[12] 卢艳慧, 陆菊明, 王淑玉, 等. 国际糖尿病联盟与中国糖尿病学会关于代谢综合征诊断标准的比较分析[J]. 中华医学杂志, 2006,86(6):386-389. LU Yanhui, LU Juming, WANG Shuyu, et al. Comparison of the diagnostic criteria of metabolic syndrome by International Diabetes Federation and that by Chinese Medical AssociationD iabetes Branch[J]. National Medical Journal of China, 2006, 86(6):386-389.
[13] Kanbara A, Miura Y, Hyogo H, et al. Effect of urine pH changed by dietary intervention on uric acid clearance mechanism of pH-dependent excretion of urinary uric acid[J]. Nutr J, 2012, 11:39. doi:10.1186/1475-2891-11-39
[14] Bell DS. Beware the low urine pH-the major cause of the increased prevalence of nephrolithiasis in the patient with type 2 diabetes[J]. Diabetes Obes Metab, 2012, 14(4):299-303.
[15] Rebholz CM, Coresh J, Grams ME, et al. Dietary acid load and incident chronic kidney disease: results from the ARIC study[J]. Am J Nephrol, 2015, 42(6):427-435.
[16] 张龙江. 肥胖与胰岛素抵抗[J]. 实用儿科临床杂志, 2009,24(20):1548-1551.
[17] Feroe AG, Attanasio R, Scinicariello F. Acrolein metabolites, diabetes and insulin resistance[J]. Environ Res, 2016, 148:1-6. doi: 10.1016/j.envres.2016.03.015.
[18] 丁少川, 张瑞珍, 刘成桂. 2型糖尿病与胰岛素抵抗和代谢综合征[J]. 现代预防医学, 2009,36(03):564-566.
[19] Hayata H, Miyazaki H, Niisato N, et al. Lowered extracellular pH is involved in the pathogenesis of skeletal muscle insulin resistance[J]. Biochem Biophys Res Commun, 2014, 445(1):170-174.

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尿液pH与代谢综合征的相关性

Analysis on the relationship between urine pH and metabolic syndrome

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