部分分布竞争风险模型及其在健康风险评估中的应用

doi:10.6040/j.issn.1671-7554.0.2017.367

山东大学学报（医学版） ›› 2017, Vol. 55 ›› Issue (6): 37-41.doi: 10.6040/j.issn.1671-7554.0.2017.367

部分分布竞争风险模型及其在健康风险评估中的应用

王金涛^1,2,3,苏萍^2,3,袁中尚^2,3,薛付忠^2,3

1. 山东大学(威海)数学与统计学院统计学系, 山东威海 264200;2. 山东大学公共卫生学院生物统计学系, 山东济南 250012;3. 山东大学齐鲁生物医学大数据研究中心, 山东济南 250012

收稿日期:2017-04-27 出版日期:2017-06-10 发布日期:2017-06-10
通讯作者: 薛付忠. E-mail:xuefzh@sdu.edu.cn E-mail:xuefzh@sdu.edu.cn
基金资助:
山东大学青年学者未来计划建设项目(2016WLJH23)

Sub-distribution hazard model and its applications in health risk assessment

WANG Jintao^1,2,3, SU Ping^2,3, YUAN Zhongshang^2,3, XUE Fuzhong^2,3

1. Department of Statistics, School of Mathematics and Statistics, Shandong University, Weihai 264200, Shandong, China;
2. Department of Biostatistics, School of Public Health, Shandong University, Jinan 250012, Shandong, China;
3. Cheeloo Research Center for Biomedical Big Data, Shandong University, Jinan 250012, Shandong, China

Received:2017-04-27 Online:2017-06-10 Published:2017-06-10

摘要/Abstract

摘要： 目的介绍部分分布竞争风险模型原理及其在健康风险评估中的应用。方法介绍部分分布竞争风险模型如何解决慢性病风险评估中的竞争风险问题,进一步结合山东省多中心缺血性脑卒中病例随访队列,阐明部分分布竞争风险模型的实用性。结果部分分布风险模型充分考虑了竞争风险的影响,将竞争结局融入风险集(risk set)定义,而不是武断地将竞争结局的出现当作删失值处理,其建模效果优于传统的Cox模型。依托山东多中心缺血性脑卒中病例随访队列,将其用于缺血性脑卒中死亡结局风险评估,显示出良好的实用性。结论部分分布竞争风险模型能够建立协变量和累积发病率函数间的直接关系,较好地处理了健康风险评估的竞争风险问题,具有很强的实用性。

关键词: 健康风险评估, 竞争风险, Cox模型, 部分分布竞争风险模型

Abstract: Objective To introduce the theory of sub-distribution hazard model and its applications in health risk assessment. Methods Given that competing risks are commonly encountered in health risk assessment, we have introduced the sub-distribution hazard model, and further evaluate itsefficiency and application based on the Shandong Multi-center cohort of hemorrhagic cerebral apoplexy. Results Under the framework of competing risk, the sub-distribution hazard model took the competing endpoint into the construction of the risk set, other than treating the competing endpoint simply as the censoring. Thus, it can have better performance than the traditional Cox model. Based on the Shandong Multi-center cohort of hemorrhagic cerebral apoplexy, it showed a good practicability in risk assessment of stroke death. Conclusion The sub-distribution hazard model can directly link the covariates with the cumulative incidence function, and can efficiently deal with the competing risk problem.

Key words: Health risk assessment, Cox model, Sub-distribution hazard model, Competing risks

中图分类号:

R195

王金涛,苏萍,袁中尚,薛付忠. 部分分布竞争风险模型及其在健康风险评估中的应用[J]. 山东大学学报（医学版）, 2017, 55(6): 37-41.

WANG Jintao, SU Ping, YUAN Zhongshang, XUE Fuzhong. Sub-distribution hazard model and its applications in health risk assessment[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2017, 55(6): 37-41.

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部分分布竞争风险模型及其在健康风险评估中的应用

Sub-distribution hazard model and its applications in health risk assessment

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