体素内不相干运动磁共振成像对糖尿病患者肾脏功能的评价作用

doi:10.6040/j.issn.1671-7554.0.2015.1065

摘要/Abstract

摘要： 目的探讨体素内不相干运动磁共振成像(IVIM-MRI)评价糖尿病患者肾脏功能的价值。方法采用3.0T磁共振分别对20例糖尿病患者(糖尿病组)和正常对照组进行肾脏IVIM扫描,比较两组间及组内皮、髓质的弥散系数(D)、灌注分数(f)、灌注相关弥散系数(D* )间的差异。结果糖尿病组皮质D值及f值大于正常对照组,差异有统计学意义(t=2.187, P=0.035; t=2.334, P=0.025);糖尿病组髓质D值及f值大于正常对照组,但差异无统计学意义(t=1.753, P=0.088; t=0.682, P=0.499);糖尿病组皮、髓质D*值均大于正常对照组,但差异无统计学意义(t=0.088, P=0.93; t=0.592, P=0.557)。同组内皮质与髓质间D值、 f值及D*值差异均有统计学意义(糖尿病组:t=9.64, P=0.002; t=12.163, P=0.001; t=15.993, P=0.001;正常对照组:t=11.228, P=0.001; t=12.055, P=0.001; t=14.708, P=0.001)。结论 IVIM-MRI可无创地评价糖尿病患者肾脏功能,增加了其在临床的应用范围。

关键词: 体素内不相干运动磁共振成像, 糖尿病, 弥散系数, 肾功能, 灌注分数

Abstract: Objective To investigate the value of introvoxel incoherent motion magnetic resonance imaging(IVIM-MRI)in evaluating renal function of diabetes mellitus. Methods IVIM-MRI was performed in 20 cases of diabetes mellitus(diabetic group)and 20 healthy controls(control group)using 3.0T MR system. The differences of diffusion coefficient(D), perfusion fraction(f), and pseudodiffusion coefficient(D*)were compared. Results D and f values of renal cortex of the diabetic group were significantly higher than those of the control group(t=2.187, P=0.035; t=2.334, P=0.025). D and f values of renal medulla of the diabetic group were higher than those of control group, but with no significant differences(t=1.753, P=0.088; t=0.682, P=0.499). D* values of renal medulla and cortex of the diabetic group were higher than those of the control group, but without significant differences(t=0.088, P=0.93; t=0.592, P=0.557). D, f, D* values of renal medulla were significantly different from those of renal cortex in both diabetic and control groups(diabetes mellitus group t=9.64, P=0.002; t=12.163, P=0.001; t=15.993, P=0.001; control group t=11.228, P=0.001; t=12.055, P=0.001; t=14.708, P=0.001). Conclusion Introvoxel incoherent motion MR imaging can evaluate the renal function of diabetic patients non-invasively.

Key words: Diabetes mellitus, Renal function, Perfusion fraction, Introvoxel incoherent motion MR imaging, Diffusion coefficient

中图分类号:

R587.1

俞璐,刘强. 体素内不相干运动磁共振成像对糖尿病患者肾脏功能的评价作用[J]. 山东大学学报（医学版）, 2016, 54(11): 68-71.

YU Lu, LIU Qiang. Introvoxel incoherent motion MR imaging for the assessment of renal function of diabetes mellitus[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(11): 68-71.

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