2型糖尿病患者腹胀与小肠细菌过度生长的关系

doi:10.6040/j.issn.1671-7554.0.2015.343

山东大学学报（医学版） ›› 2016, Vol. 54 ›› Issue (1): 45-47.doi: 10.6040/j.issn.1671-7554.0.2015.343

2型糖尿病患者腹胀与小肠细菌过度生长的关系

张莉¹,朱惠明¹,王艳梅²,江堤¹,孙贤久¹,乐有林¹

1.东莞东华医院消化内科, 广东东莞 523000;
2.河南大学护理学院, 河南开封 475000

收稿日期:2015-04-01 出版日期:2016-01-11 发布日期:2016-01-11
通讯作者: 张莉. E-mail:zhangli2219@126.com E-mail:zhangli2219@126.com

Relationship between abdominal distension and small intestine bacterial overgrowth in type 2 diabetic patients

ZHANG Li¹, ZHU Huiming¹, WANG Yanmei², JIANG Di¹, SUN Xianjiu¹, LE Youlin²

1. Department of Gastroenterology, Donghua Hospital of Dongguan, Dongguan 523000, Guangdong, China;
2. Nursing College of Henan University, Kaifeng 475000, Henan, China

Received:2015-04-01 Online:2016-01-11 Published:2016-01-11

摘要/Abstract

摘要： 目的探讨2型糖尿病患者腹胀与小肠细菌过度生长(SIBO)的关系。方法将96例2型糖尿病患者分为血糖正常且无腹胀组、血糖正常并腹胀组、血糖升高无腹胀组、血糖升高并腹胀4组,通过乳果糖氢呼气试验分别检测其SIBO情况及口盲时间,并与健康对照组进行组间比较分析。结果血糖升高并腹胀组患者的SIBO阳性率较其他组患者明显增高,差异有统计学意义。腹胀组SIBO阳性率与健康对照组比较有统计学差异(P<0.05),4组患者口盲时间与健康对照组比较均有统计学意义(P<0.01)。结论 2型糖尿病合并腹胀患者易发生SIBO,与口盲时间延长相关,其可能是腹胀发生的重要发病机制。

关键词: 2型糖尿病, 小肠细菌过度生长, 氢呼气试验

Abstract: Objective To explore the relationship between abdominal distension and small intestine bacterial overgrowth(SIBO)in type 2 diabetic patients. Methods A total of 96 type 2 diabetic patients were divided into 4 groups: normal blood glucose and no abdominal distention group(control group), normal blood glucose and abdominal distension group(abdominal distension group), hyperglycemia without abdominal distension group, and hyperglycemia and abdominal distention group. SIBO and the mouth-intestine transit time were detected with lactulose hydrogen breath test, and the results of the control group were compared with those of the other groups. Results The positive rate of SIBO in the hyperglycemia and abdominal distention group was higher than in the other groups, and the difference was significant. There was difference in the positive rate of SIBO between the control group and abdominal distension group(P<0.05). There were significant differences in the mouth-intestine transit time between the control group and the other 3 groups(P<0.01). Conclusion Type 2 diabetic patients with abdominal distention are more liable to have SIBO. The long mouth-intestine transit time may be related to abdominal distension.

Key words: Type 2 diabetes, Small intestinal bacterial overgrowth, Hydrogen breath test

中图分类号:

R575

张莉,朱惠明,王艳梅,江堤,孙贤久,乐有林. 2型糖尿病患者腹胀与小肠细菌过度生长的关系[J]. 山东大学学报（医学版）, 2016, 54(1): 45-47.

ZHANG Li, ZHU Huiming, WANG Yanmei, JIANG Di, SUN Xianjiu, LE Youlin. Relationship between abdominal distension and small intestine bacterial overgrowth in type 2 diabetic patients[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2016, 54(1): 45-47.

参考文献

[1] 张波, 杨文英. 糖尿病防治在中国[J]. 中华糖尿病杂志, 2015, 7(1):3-5.
[2] Gabrielli M, D'Angelo G, Di Rienzo T, et al. Diagnosis of small intestinal bacterial overgrowth in the clinical practice[J]. Eur Rev Med Pharmacol Sci, 2013, 17(2):30-35.
[3] Jan Bures, Jiri Cyrany, Darina Kohoutova, et al. Small intestinal bacterial overgrowth syndrome[J]. World J Gastroenterol, 2010, 16(24):2978-2990.
[4] 王倩,张莹,侯为开,等.2型糖尿病性腹泻与肠神经系统病变关系的探讨[J].山东大学学报(医学版),2011, 49(8):13-20. WANG Qian, ZHANG Ying, HOU Weikai, et al. Correlation between type 2 diabetes associated diarrhea and changes of enteric nervous system[J]. Journal of Shandong University(Health Sciences), 2011, 49(8):13-20.
[5] Rana SV, Malik A. Hydrogen breath tests in gastrointestinal diseases[J]. Indian J Clin Biochem, 2014, 29(4):398-405.
[6] Di Stefano M, Mengoli C, Bergonzi M, et al. Hydrogen breath test and intestinal gas production[J]. Eur Rev Med Pharmacol Sci, 2013, 17(2):36-38.
[7] Rana SV, Sharma S, Kaur J, et al. Comparison of lactulose and glucose breath test for diagnosis of small intestinal bacterial overgrowth in patients with irritable bowel syndrome[J]. Digestion, 2012, 85(3):243-247.
[8] Kwak DS, Jun DW, Seo JG, et al. Short-term probiotic therapy alleviates small intestinal bacterial overgrowth, but does not improve intestinal permeability in chronic liver disease[J]. Eur J Gastroenterol Hepatol, 2014, 26(12):1353-1359.
[9] Drossman DA. Treatment for bacterial overgrowth in the irritable bowel syndrome [J]. Ann Intern Med, 2006, 145(8):626-628.
[10] Hulston CJ, Churnside AA, Venables MC. Probiotic supplementation prevents high-fat, overfeeding-induced insulin resistance in human subjects[J]. Br J Nutr, 2015, 113(4):596-602.

相关文章 15

[1]	张宝文,雷香丽,李瑾娜,罗湘俊,邹容. miR-21-5p靶向调控TIMP3抑制2型糖尿病肾病小鼠肾脏系膜细胞增殖及细胞外基质堆积[J]. 山东大学学报 (医学版), 2020, 1(7): 7-14.
[2]	苏萍,杨亚超,杨洋,季加东,阿力木·达依木,李敏,薛付忠,刘言训. 健康管理人群2型糖尿病发病风险预测模型[J]. 山东大学学报（医学版）, 2017, 55(6): 82-86.
[3]	李帅,王雅琳,孙忠文,朱梅佳. Nod样受体蛋白3炎性体在2型糖尿病脑微血管内皮细胞中的变化及变化机制[J]. 山东大学学报（医学版）, 2017, 55(3): 6-11.
[4]	杨洋,张光,张成琪,宋心红,薛付忠,王萍,王丽,刘言训. 基于体检队列的2型糖尿病风险预测模型[J]. 山东大学学报（医学版）, 2016, 54(9): 69-72.
[5]	彭力,强晔,赵蕙琛,陈诗鸿,姚伟东,刘元涛. 2型糖尿病患者应用西格列汀的短期疗效及影响因素[J]. 山东大学学报（医学版）, 2016, 54(8): 60-63.
[6]	林栋,管庆波. 2型糖尿病男性患者血清睾酮水平低下对非酒精性脂肪肝的影响[J]. 山东大学学报（医学版）, 2016, 54(7): 33-37.
[7]	木哈达斯·吐尔逊依明,帕它木·莫合买提,托兰古丽·买买提库尔班. CDKAL1(rs10946398 C/A)基因多态性与2型糖尿病易感性关系Meta分析[J]. 山东大学学报（医学版）, 2016, 54(2): 75-85.
[8]	于宁,高燕燕,咸玉欣,牛佳鹏,李莉,王静,曹彩霞. 艾塞那肽对2型糖尿病合并非酒精性脂肪肝患者肝脏脂肪含量及血清chemerin水平的影响[J]. 山东大学学报（医学版）, 2016, 54(11): 51-55.
[9]	刘言训, 刘佳, 张涛, 王璐, 薛付忠, 王萍. 基于纵向监测队列的2型糖尿病与甲状腺结节的关联性[J]. 山东大学学报（医学版）, 2015, 53(8): 83-86.
[10]	裴蕾蕾, 孙中华, 李哲, 赵文萍. 西格列汀联合大剂量胰岛素治疗2型糖尿病的临床观察[J]. 山东大学学报（医学版）, 2015, 53(2): 39-42.
[11]	胡芳志, 张正军, 耿厚法, 梁秋华, 孙琳. 2型糖尿病患者尿微量白蛋白与脑组织代谢物变化的关系[J]. 山东大学学报（医学版）, 2015, 53(2): 43-47.
[12]	李方. 可溶性晚期糖基化终末产物受体及其基因多态性与2型糖尿病的易感性分析[J]. 山东大学学报（医学版）, 2015, 53(12): 57-61.
[13]	秦祥德, 杨春云, 张媛, 倪一虹, 于超, 冯晓丽, 徐成伟. 2型糖尿病合并下肢骨折患者凝血分子标志物的变化及其与血栓形成的关系[J]. 山东大学学报（医学版）, 2015, 53(11): 55-58.
[14]	李寒冰, 高燕燕, 李莉, 曹彩霞, 咸玉欣, 王静, 牛佳鹏. 兰索拉唑与艾塞那肽联用对2型糖尿病患者胃泌素及胃泌酸调节素的影响[J]. 山东大学学报（医学版）, 2015, 53(11): 64-68.
[15]	潘娟, 胡慧. 系统性红斑狼疮合并2型糖尿病1例个案管理报道[J]. 山东大学学报（医学版）, 2014, 52(S2): 64-65.

多维度评价

Viewed

Full text

Abstract

Cited

Shared

Discussed

2型糖尿病患者腹胀与小肠细菌过度生长的关系

Relationship between abdominal distension and small intestine bacterial overgrowth in type 2 diabetic patients

PDF (PC)

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

多维度评价

本文评价

推荐阅读 0