老年2型糖尿病患者听力损害特征及相关因素分析

山东大学学报(医学版)

老年2型糖尿病患者听力损害特征及相关因素分析

樊云霞¹，韩峰²，崔小康¹，董明¹，肖晓燕¹，许安廷³，任建民¹

1. 山东大学齐鲁医院内分泌科，济南 250012； 2. 章丘市人民医院内分泌科，济南 250200； 3. 山东大学齐鲁医院耳鼻喉科，济南 250012

收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2008-07-16 发布日期:2008-07-16
通讯作者: 任建民

Characterization of hearing loss in aged type 2 diabetics and its correlation factors

FAN Yun-xia¹，　HAN Feng²，　CUI Xiao-kang¹，　DONG Ming¹，　XIAO Xiao-yan¹，　XU An-ting³，　REN Jian-min¹

1. Department of Endocrinology, Qilu Hospital of Shandong University, Jinan 250012, China; 2. Department of Endocrinology, Zhangqiu People′s Hospital, Jinan 250200, China; 3. Department of Otorhinolaryngology, Qilu Hospital of Shandong University, Jinan 250012, China

Received:1900-01-01 Revised:1900-01-01 Online:2008-07-16 Published:2008-07-16
Contact: REN Jian-min

摘要/Abstract

摘要：

目的〓〖HTK〗探讨老年2型糖尿病患者听力损害的特征及其发病的相关因素。〖HTW〗方法〓〖HTK〗对118例老年2型糖尿患者（糖尿病组）和50例老年非糖尿病者（正常对照组）进行纯音听阈、畸变产物耳声发射（DPOAE）、听觉脑干诱发电位（ABR）测定，比较两组听力学检查的特点，并应用Logistic回归分析导致老年2型糖尿病患者听力损害的危险因素。〖HTW〗结果〓〖HTK〗① Logistic回归分析显示，年龄、病程、LDL-C、糖尿病肾病、视网膜病变是老年2型糖尿病患者听力损害的危险因素；② 纯音测听检查结果表明，糖尿病组和对照组均表现为高频听力受损为主，糖尿病组右耳较左耳更易受损；③ 糖尿病组畸变产物耳声发射振幅较对照组低，且右耳振幅更低(P＜0.05)；④ 糖尿病组听阈阈上40dB Ⅲ、Ⅴ波潜伏期和Ⅰ-Ⅲ波间期较对照组明显延长(P＜0.05)，左右耳无明显差异。〖HTW〗结论〓〖HTK〗老年2型糖尿病患者听力损害以高频听力受损为主，且右耳更易受损。年龄、病程、高LDL-C、糖尿病微血管并发症是其发病的危险因素。

关键词: 听力学检测, 危险因素, 听力损害, 非胰岛素依赖型, 糖尿病

Abstract:

Objective〓〖WTBZ〗To study the characteristics of hearing loss in aged type 2 diabetics and to explore its correlation factors. 〖WTHZ〗Methods〓〖WTBZ〗118 aged type 2 diabetics and 50 controls were enrolled in this study. Pure-tone audiometry, distortion product otoacoustic emissions (DPOAE) and auditory brainstem responses (ABR) were determined. 〖WTHZ〗Results〓〖WTBZ〗① Logistic regressive analysis showed that independent risk factors associated with hearing loss of the aged type 2 diabetics were age,course of the T2DM, LDL-C , diabetic nephropathy and diabetic retinopathy; ② The pure-tone audiometry test showed that there was a great deficit at high frequencies in the two groups, and a stronger tendency of affecting the right ear than the left; ③ The DPOAE test showed that the amplitude of DPOAE in diabetics was decreased compared with the control group, and a stronger tendency of affecting the right ear than the left ear(P＜0.05); ④ The ABR test showed that latencies of wavesⅢ,Ⅴand interwaveⅠ-Ⅲ of 40dB above the auditory threshold were longer in diabetics(P＜0.05), and there was no statistical significance between the left ear and the right. 〖WTHZ〗Conclusions〓〖WTBZ〗Hearing impairment in aged type 2 diabetics is significant at high frequencies, especially in the right ear. Age, course of the T2DM and LDL-C and diabetic micrangium complications are the risk factors.

Key words: Diabetes mellitus, non-insulin-dependent, Risk factors, Hearing loss, Audiometry

中图分类号:

R587.2

樊云霞,韩峰,崔小康,董明,肖晓燕,许安廷,任建民 . 老年2型糖尿病患者听力损害特征及相关因素分析[J]. 山东大学学报(医学版), 2008, 46(7): 707-709.

FAN Yun-xia,HAN Feng,CUI Xiao-kang,DONG Ming,XIAO Xiao-yan,XU An-ting,REN Jian-min

. Characterization of hearing loss in aged type 2 diabetics and its correlation factors[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2008, 46(7): 707-709.

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