青光眼患者视网膜神经纤维层厚度与对应视野缺损的相关性研究

摘要/Abstract

摘要： 目的探讨青光眼患者视乳头不同方位视网膜神经纤维层厚度与对应区域视野缺损之间的相关性。方法对40名有过急性发作史、眼压控制在25 mmHg以下2周以上的原发急性闭角型青光眼患者,采用光学相干断层成像技术(OCT)进行6个方位的视神经纤维层(RNFL)厚度检测和全自动视野计进行72点视野检查。比较患者的颞上、颞下及平均视网膜神经纤维层厚度与对应区域鼻下、鼻上及平均视野缺损之间的关系。结果颞下RNFL厚度与鼻上视野缺损具有高度相关性(r=-0.81,P<0.05),颞上RNFL厚度与鼻下视野缺损具有高度相关性(r=-0.83,P<0.05),平均RNFL厚度与平均视野缺损具有负相关(r=-0.62,P<0.05)。结论 RNFL厚度一定程度上可以反映视野缺损深度。

关键词: 孕妇, 视网膜神经纤维层厚度, 破伤风, 护理, 免疫, 光学相干断层成像技术, 视野缺损

Abstract: Objective To investigate the correlation between the thickness of retinal nerve fiber layer(RNFL) and corresponding visual field defect in glaucoma patients. Methods Forty angle-closure glaucoma patients were enrolled. Optical coherence tomography (OCT) was performed to obtain the thickness of RNFL in 6 positions of optic nerve head and the corresponding visual field sensitivity or visual field defect. Association was analyzed between thickness of temporal-superior RNFL and the visual field defect of nasal-inferior, between the thickness of temporal-inferior RNFL and the visual field defect of nasal-superior, between the thickness of mean RNFL and mean field defect. Results Linear correlation was found between the temporal-superior RNFL thickness and the nasal-inferior visual field defect (r=-0.83), between the temporal-inferior RNFL thickness and the nasal-superior visual field defect(r=-0.80). The negative correlation (r=-0.60) was found between the mean thickness of RNFL and the mean visual defect. Conclusion The thickness of RNFL can partly reflect the depth of the visual field defect.

Key words: OCT, RNFL, visual field defect

中图分类号:

R775.2

曹国凡, 薛劲松, 姚进, 蒋沁. 青光眼患者视网膜神经纤维层厚度与对应视野缺损的相关性研究[J]. 山东大学学报（医学版）, 2014, 52(S1): 68-70.

CAO Guo-fan, XUE Jin-song, YAO Jin, JIANG Qin. Study on correlation between thickness of retinal nerve fiber layer and visual field defect in glaucoma patients[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2014, 52(S1): 68-70.

参考文献

[1] Gordon,MO,Beiser JA,Brandt JG,et al.The Ocular Hypertension Treatment Study: baseline factors that predict the onset of primary open-angle glaucoma[J].Arch Ophthalmol,2002: 120(6): 714-720.
[2] Quigley HA,Dunkelberger GR,Green WR,et al.Retinal ganglion cell atrophy correlated with automated perimetry in human eyes with glaucoma[J].Am J Ophthalmol,1989,107(5): 453-464.
[3] 葛坚,赵家良,黎晓新.眼科学[M].北京:人民卫生出版社: 2010,244.
[4] Ferreras A,Pablo LE,Garway-Heath DF,et al.Mapping standard automated perimetry to the peripapillary retinal nerve fiber layer in glaucoma[J].Invest Ophthalmol Vis Sci,2008,49(7): 3018-3025.
[5] Medeiros FA,Alencar LM,Zangwill LM,Bowd C,Sample PA,Weinreb RN,et al.Prediction of functional loss in glaucoma from progressive optic disc damage[J].Arch Ophthalmol,2009,127(10): 1250-1256.
[6] Yalvac Ilgaz Sagdic,Altunsoy Muhsin ,Cansever Semra,et al.The Correlation Between Visual Field Defects and Focal Nerve Fiber Layer Thickness Measured With Optical Coherence Tomography in the Evaluation of Glaucoma[J].Journal of Glaucoma,2009,18(1): 53-61.

相关文章 15

[1]	徐平于国放李霞. 不同类型甲状腺上动脉PSV对Graves病与桥本氏甲状腺炎鉴别诊断的价值[J]. 山东大学学报(医学版), 2209, 47(6): 62-64.
[2]	黄方康瑞吴春林. VEGFC、NF-κBp65及Survivin在鼻咽癌中的表达及临床意义[J]. 山东大学学报(医学版), 2209, 47(6): 83-.
[3]	王欣，邢春燕，杨艳平. 血清磷酸丙酮酸水合酶检测对诊断侵袭性白念珠菌感染的临床价值[J]. 山东大学学报(医学版), 2209, 47(6): 92-94.
[4]	闫鹏王蓉杜怡峰沈伦乾. 老年性痴呆患者尿中AD7c-NTP含量的研究[J]. 山东大学学报(医学版), 2209, 47(6): 106-.
[5]	李刚,薛皓,邱伟,赵荣荣. 脑胶质瘤抑制性免疫微环境形成机制及研究进展[J]. 山东大学学报 (医学版), 2020, 1(8): 67-73.
[6]	索东阳,申飞,郭皓,刘力畅,杨惠敏,杨向东. Tim-3在药物性急性肾损伤动物模型中的表达及作用机制[J]. 山东大学学报 (医学版), 2020, 1(7): 1-6.
[7]	刘攀,何天祎,赵汝星,孙宇,陈丽. 百令胶囊对Graves病患者自身免疫的调理作用[J]. 山东大学学报（医学版）, 2017, 55(9): 90-95.
[8]	聂思月,王震,孙靖宇,刘杰,李娟,魏小娟,路春晓,吕兴龑,王淑云,孙玉萍. ANGPTL5在人胃癌组织中的表达及临床意义[J]. 山东大学学报（医学版）, 2017, 55(8): 61-65.
[9]	郑瑾,张江伟,王旭珍,匡陪丹,何晓丽,薛武军. 肾移植术后早期淋巴细胞及DSA监测在诊断移植排斥反应中的意义[J]. 山东大学学报（医学版）, 2017, 55(7): 89-94.
[10]	王永强,张维全,孙启峰,董晓鹏,彭传亮,张媛,赵小刚. 细胞角蛋白14基因在非小细胞肺癌中的表达与意义[J]. 山东大学学报（医学版）, 2017, 55(3): 83-87.
[11]	周兰兰,潘学谊,郭煜. 48例急性混合细胞表型白血病患者的临床特征及预后[J]. 山东大学学报（医学版）, 2017, 55(2): 79-83.
[12]	张希英,翟春颜,李劲松,韩博. 中国尤文肉瘤患者EZH2蛋白表达与临床病理学参数及预后的关系[J]. 山东大学学报（医学版）, 2017, 55(2): 84-91.
[13]	吴倩,倪阳,杨清锐,孙红胜. 双眼睑肿胀及双侧颌下包块1例——IgG4相关性疾病的诊断与思考[J]. 山东大学学报（医学版）, 2017, 55(11): 93-96.
[14]	刘惠苓,王兴文,冯少滨,冯虹,韩俊庆. B类I型清道夫受体的高表达与结肠癌患者预后的相关性[J]. 山东大学学报（医学版）, 2017, 55(10): 84-89.
[15]	吴卢侃璇,朱珊,于金习,吕椿子,李明江. 程序性死亡因子-1及其配体-1在子宫腺肌病中的表达及意义[J]. 山东大学学报（医学版）, 2017, 55(10): 90-96.

多维度评价

Viewed

Full text

Abstract

Cited

Shared

Discussed