环氧化酶2基因多态性与动脉粥样硬化缺血性脑卒中的相关性

山东大学学报(医学版) ›› 2209, Vol. 47 ›› Issue (6): 95-98.

环氧化酶2基因多态性与动脉粥样硬化缺血性脑卒中的相关性

郝跃伟刘雪平赵婷婷郑敏王一兵

1．山东大学附属省立医院老年神经科, 济南 250021； 2. 山东大学附属省立医院抗衰老实验室，济南 250021；3. 山东省胸科医院呼吸内科，济南 250013； 4. 山东省荣军总医院神经内科，济南 250013

收稿日期:2009-01-19 出版日期:2009-06-16 发布日期:2209-06-25
通讯作者: 刘雪平（1962- ），女，主任医师，博士，主要从事脑血管病的研究。 E-mail:lxp6133@yahoo.com.cn
作者简介:郝跃伟（1981- ），男，硕士研究生，主要从事脑血管病的研究。E-mail:hyw203@yahoo.com.cn

Relationship between the COX-2 gene polymorphisms and atherothrombotic ischemic stroke

HAO Yue-Wei, LIU Xue-Ping, ZHAO Ting-Ting, ZHENG Min, WANG Yi-Bing

1. Department of Geratology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, China;2. Department of Antiaging,Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, China;3. Department of Respiratory, Shandong Provincial Chest Hospital, Jinan 250013, China;4. Department of Neurology, Shandong Provincial Rongjun General Hospital, Jinan 250013, China

Received:2009-01-19 Online:2009-06-16 Published:2209-06-25

摘要/Abstract

摘要：

目的探讨中国汉族人环氧化酶2的单核苷酸多态性位点及单元型与动脉粥样硬化缺血性脑卒中的关系。方法对626名缺血性脑卒中患者和604名健康者检测环氧化酶2的两个多态位点：-1195G/A和8473T/C，并对每个基因位点和两个位点的单元型进行分析。结果 8473T/C位点的基因型TC在疾病组中明显增多（经混杂因素校正后，OR=1.329, 95%CI=1.028-1.719），单元型A-1195C8473的比率在疾病组较对照组高，Logistic回归分析显示带有单元型A-1195C8473的个体更容易患缺血性脑卒中(经混杂因素校正后，OR=1.372, 95%CI=1.070-1.760)。结论在汉族人环氧化酶2的基因型TC（8473T/C位点）和单元型A-1195C8473可能是脑梗塞的遗传易感因素。

关键词: 基因型；单元型；炎症；动脉硬化；脑梗塞

Abstract:

Objective To investigate whether single nucleotide polymorphisms (SNPs) and haplotypes of COX-2 gene were susceptible to atherothrombotic ischemic stroke in the Chinese Han population. Methods In this study two variants (-1195G/A and 8473T/C) of COX-2 were examined among 626 patients with ischemic stroke and 604 control subjects. Polymorphisms were studied both individually and as haplotypes. Results The genotype TC in 8473T/C was significantly overexpressed in patients (OR=1.329, 95%CI=1.028-1.719, adjusted for confounding factors). Further, the haplotype AC of -1195G/A and 8473T/C was significantly higher in patients than that in the control subjects. Logistic regression analysis revealed that individuals having haplotype AC had an increased possibility of ischemic stroke (OR=1.372, 95%CI=1.070-1.760, adjusted by confounding factors). Conclusion The results suggest that genotype TC of COX-2 8473T/C and haplotype AC containing -1195A and 8473C may be a crucial risk factor of genetic susceptibility to ischemic stroke in the Chinese Han population.

Key words: Genotype； Haplotypes； Inflammation； Arteriosclerosis； Brain infarction

中图分类号:

R743.1

郝跃伟刘雪平赵婷婷郑敏王一兵. 环氧化酶2基因多态性与动脉粥样硬化缺血性脑卒中的相关性[J]. 山东大学学报(医学版), 2209, 47(6): 95-98.

HAO Yue-Wei, LIU Xue-Ping, ZHAO Ting-Ting, ZHENG Min, WANG Yi-Bing. Relationship between the COX-2 gene polymorphisms and atherothrombotic ischemic stroke[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2209, 47(6): 95-98.

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