血清Isthmin1、Gremlin2水平与2型糖尿病患者视网膜病变的相关性

doi:10.6040/j.issn.1671-7554.0.2025.0087

摘要/Abstract

摘要： 目的探讨2型糖尿病(type 2 diabetes mellitus, T2DM)患者血清Isthmin1(ISM1)、Gremlin2(GREM2)水平与糖尿病性视网膜病变(diabetic retinopathy, DR)的关系。方法选取2023年1月1日至2023年12月31日在青岛大学附属烟台毓璜顶医院内分泌科治疗的148例T2DM患者,根据是否合并DR分为DR组(n=67)与非DR(non-diabetic retinopathy, NDR)组(n=81)。酶联免疫吸附法检测血清ISM1、GREM2水平。结果 DR组患者糖尿病病程、高血压病史、收缩压、白介素-6、尿白蛋白/肌酐比值(urinary albumin-to-creatinine ratio, UACR)、cIMT水平均高于NDR组(P均<0.05);与NDR组比较,DR组ISM1水平［(2.63±0.99)ng/mL vs.(1.24±0.72)ng/mL］及GREM2水平［1 001.01(920.00,1 149.71)pg/mL vs. 896.51(771.02,997.45)pg/mL］明显升高(P均<0.001);偏相关分析显示,校正年龄及性别后,DR与收缩压、甘油三酯、UACR、颈动脉内膜中层厚度(carotid intima-mediathickness, cIMT)、ISM1、GREM2呈正相关(P均<0.05);多因素Logistic回归分析显示,ISM1、GREM2、(systolic blood pressure, SBP)及UACR是T2DM患者发生DR的独立影响因素(P均<0.05)。结论 T2DM 患者DR的风险随着ISM1、GREM2的升高而增加,通过检测其血清中的水平可能有利于DR的早期筛查。

关键词: Isthmin1, Gremlin2, 糖尿病性视网膜病变, 2型糖尿病

Abstract: Objective To investigate the correlation between the levels of serum Isthmin1(ISM1), Gremlin2(GREM2)and diabetic retinopathy(DR)in patients with type 2 diabetes mellitus(T2DM). Methods A total of 148 patients with T2DM who were treated in the Affiliated Yantai Yuhuangding Hospital of Qingdao University from January 1,2023 to December 31,2023 were included in the study and divided into a non-DR(NDR)group(n=81)and a DR group(n=67)based on the absence or presence of DR. Serum ISM1 and GREM2 levels were measured by enzyme-linked immunosorbent assay. Results Significant differences in diabetic duration, the presence of hypertension, systolic blood pressure(SBP), interleukin 6, urinary albumin-to-creatinine ratio(UACR)and carotid intima-media thickness(cIMT)were observed between the NDR and DR groups(all P<0.05). Compared with the NDR group, DR group had higher levels of ISM1 ［2.63±0.99 vs. 1.24±0.72 ng/mL］ and GREM2 ［1 001.01(920.00,1 149.71), vs. 896.51(771.02,997.45)pg/mL］(all P<0.001). After adjustments for age and gender, partial correlation analysis revealed that the presence of DR was positively correlated with SBP, triglycerides, UACR, cIMT, ISM1 and GREM2(all P<0.05). Multivariate Logistic regression analysis showed that ISM1, GREM2, SBP and UACR were independent influencing factors of DR in patients with T2DM(all P<0.05). Conclusion The risk of DR in T2DM patients increases with the elevation of ISM1 and GREM2, and early screening for DR may be facilitated by detecting their levels in serum.

Key words: Isthmin1, Gremlin2, Diabetic retinopathy, Type 2 diabetes mellitus

中图分类号:

R587.1

孟晓梅,郝亚平,王亮,于晓,唐与晓. 血清Isthmin1、Gremlin2水平与2型糖尿病患者视网膜病变的相关性[J]. 山东大学学报 (医学版), 2025, 63(9): 102-107.

MENG Xiaomei, HAO Yaping, WANG Liang, YU Xiao, TANG Yuxiao. Correlation between the levels of serum Isthmin1, Gremlin2 and retinopathy in type 2 diabetic patients[J]. Journal of Shandong University (Health Sciences), 2025, 63(9): 102-107.

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