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山东大学学报 (医学版) ›› 2024, Vol. 62 ›› Issue (8): 9-17.doi: 10.6040/j.issn.1671-7554.0.2023.0993

• • 上一篇    

维生素K2与妊娠及妊娠相关疾病的研究进展

王瑞,于康,刘燕萍   

  • 发布日期:2024-09-20
  • 通讯作者: 刘燕萍. E-mail:liuyp1227@vip.sina.com
  • 基金资助:
    国家卫健委微量元素与营养重点实验室项目(Wlkfz202203);中国营养学会科研基金-振东国人体质与健康专项基金资助项目(CNS-ZD2021-123);中央高水平医院临床科研业务费资助(2022-PUMCH-B-055)

Research advances in Vitamin K2 and pregnancy-related diseases

WANG Rui, YU Kang, LIU Yanping   

  1. Department of Nutrition, Peking Union Medical College Hospital, Beijing 100730, China
  • Published:2024-09-20

摘要: 维生素K2(vitamin K2, VK2)是一种长期被忽视的维生素。最近越来越多的证据表明,除了止血相关蛋白的肝脏羧化作用外,VK2可以在抗氧化、心血管、骨代谢等方面发挥重要作用,而这些作用与妊娠密切相关。由于其可能的缺乏状态以及良好的安全性,最近已经有部分孕妇使用的钙补充剂和综合维生素产品中被添加了VK2这一成分。然而,据我们所知,目前医学文献中没有针对VK2和妊娠之间关系的综述。本文旨在介绍VK2在妊娠期的来源及代谢特点,阐述与妊娠期特有疾病可能的关系,评估妊娠期女性补充VK2的安全性,以期为妊娠期VK2补充剂的使用提供合理建议。

关键词: 妊娠, 维生素K2, 骨代谢, 妊娠期高血压, 腿部肌肉痉挛

Abstract: Vitamin K2(VK2)is a vitamin that has been neglected for a long time. Recently, more and more evidences show that, in addition to the hepatic carboxylation of hemostatic related proteins, VK2 can play an important role in antioxidant, cardiovascular, bone metabolism and so on, which are closely related to pregnancy. Due to its possible deficiency status and good safety, VK2 has been added to some calcium supplements and multivitamin products used by pregnant women recently. However, to our knowledge, there is no review on the relationship between VK2 and pregnancy in the medical literature. This article aims to introduce the source and metabolic characteristics of VK2 in pregnancy, elaborate the possible relationship with pregnancy-specific diseases, evaluate the safety of supplementing VK2 in pregnant women, in order to provide reasonable suggestions for the use of VK2 supplements in pregnancy.

Key words: Pregnancy, Vitamin K2, Bone metabolism, Gestational hypertension, Leg cramps

中图分类号: 

  • R714
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