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山东大学学报 (医学版) ›› 2021, Vol. 59 ›› Issue (9): 83-88.doi: 10.6040/j.issn.1671-7554.0.2021.0967

• 专家综述 • 上一篇    下一篇

医工结合:精准医学时代神经外科创新发展的战略高地

杨军1,2,3   

  1. 1. 北京大学第三医院神经外科, 北京 100191;2. 北京大学医学部精准神经外科与脑肿瘤研究中心, 北京 100191;3. 北京医学会神经外科分会智能化医疗开发和应用学组, 北京 100191
  • 发布日期:2021-10-15
  • 通讯作者: 杨军. E-mail:yangjbysy@bjmu.edu.cn
  • 基金资助:
    国家自然科学基金(82072774,81872051);北京大学临床科学家计划(BMU2019LCKXJ007);中国博士后科学基金(2020M670064);北京大学第三医院临床重点项目(BYSY2018060);北京市自然科学基金(7214271)

Medico-engineering cooperation: a strategic plateau of neurosurgery innovation and development in the era of precision medicine

YANG Jun1,2,3   

  1. 1. Department of Neurosurgery, Peking University Third Hospital, Beijing 100191, China;
    2. Center for Precision Neurosurgery and Oncology, Peking University Health Science Center, Beijing 100191, China;
    3. Intelligent Medical Development and Application Group of Neurosurgery Society of Beijing Medical Association, Beijing 100191, China
  • Published:2021-10-15

摘要: 自2015年“精准医学”概念正式提出以来,疾病的精准诊断与治疗已成为目前临床医学的时代主旋律。神经外科是大外科体系中发展较晚、专业性较强、实践难度较高、培养周期较长、学习曲线较陡峭的专科,得益于医工结合研发模式的不断成熟及普及化、常态化、规范化,神经外科得到了快速的发展。而在当前精准医学的时代背景下,神经外科已进入到了关键的发展机遇期,医工结合将成为学科创新发展的重要战略高地。综述将围绕医工结合在神经外科领域的主要突破点阐述神经外科创新发展的历程与前景。

关键词: 精准医学, 神经外科, 医工结合

Abstract: Since the concept of “precision medicine” was formally put forward in 2015, the accurate diagnosis and treatment of diseases has become the main theme of clinical medicine. Neurosurgery is a specialty with relatively late development, strong specialty, high difficulty in practice, long training period and steep learning curve in the major surgical system. Due to the continuous maturity, popularization, normalization and standardization of medico-engineering cooperation, neurosurgery has achieved rapid development. In the current era of precision medicine, neurosurgery has entered a critical development period, and medico-engineering cooperation will become an important strategic plateau for the innovation and development of the discipline. Herein, we will focus on the breakthroughs of medico-engineering cooperation in the field of neurosurgery, the history and prospects of neurosurgery innovation.

Key words: Precision medicine, Neurosurgery, Medico-engineering cooperation

中图分类号: 

  • R741.04
[1] 翁国星. 加强医工结合平台建设[J]. 中国卫生, 2021(3): 22. doi: 10.15973/j.cnki.cn11-3708/d.2021.03.011. WENG Guoxing. Strengthen the construction of platforms for medico engineering cooperation [J]. China Health, 2021(3): 22. doi: 10.15973/j.cnki.cn11-3708/d.2021.03.011.
[2] 殷琳, 江恒君, 陈燕琼, 等. 国内高校附属医院医工信结合创新机制研究[J]. 现代医院, 2018, 18(8): 1140-1144. YIN Lin, JIANG Hengjun, CHEN Yanqiong, et al. Research on the mechanism of collaborative innovation of medical science, engineering and informatics in affiliated hospitals of universities in China [J]. Modern Hospital, 2018, 18(8): 1140-1144.
[3] 梁长虹, 黄飚. 多层CT技术飞速发展, 临床应用不断创新[J]. 中华放射学杂志, 2006, 40(9): 901-902. LIANG Changhong, HUANG Biao. With the rapid development of multi-slice CT technology, the clinical application has been constantly innovated [J]. Chinese Journal of Radiology, 2006, 40(9): 901-902.
[4] 汪芳, 郝万庆, 杨利莉, 等. 256排宽体探测器CT智能心电门控技术在不控制心率患者冠状动脉CTA中的应用[J]. 中国医学影像技术, 2017, 33(7): 1080-1084. WANG Fang, HAO Wanqing, YANG Lili, et al. Clinical application of auto-ECG-gating technique of 256 row CT coronary angiography in patients without heart rate control [J]. Chinese Journal of Medical Imaging Technology, 2017, 33(7): 1080-1084.
[5] De Ciantis A, Barba C, Tassi L, et al. 7T MRI in focal epilepsy with unrevealing conventional field strength imaging [J]. Epilepsia, 2016, 57(3): 445-454.
[6] Fujiwara S, Mori Y, de la Mora DM, et al. Feasibility of IVIM parameters from diffusion-weighted imaging at 11.7T MRI for detecting ischemic changes in common carotid artery occlusion rats [J]. Sci Rep, 2020, 10(1): 8404.
[7] 马俊, 刘松涛, 牟均青. 衰减校正与非衰减校正在PET-CT诊断肿瘤中的价值[J]. 山东大学学报(医学版), 2004, 42(6): 736-738. MA Jun, LIU Songtao, MU Junqing. Value of attenuation correction and non-attenuation correction in peT-CT diagnosis of tumor [J]. Journal of Shandong University(Health Sciences), 2004, 42(6): 736-738.
[8] 杨慧, 李万湖, 陈月芹, 等. 3.0T1H-MRS 鉴别高级别胶质瘤与单发性脑转移瘤的价值[J]. 山东大学学报(医学版), 2015, 53(4): 65-70. YANG Hui, LI Wanhu, CHEN Yueqin, et al. Value of 3.0T 1 H-MRS in the differential diagnosis of high-grade brain gliomas and solitary metastatic tumors [J]. Journal of Shandong University(Health Sciences), 2015, 53(4): 65-70.
[9] 刘何鹏, 李传福, 尉从新, 等. SWI及DTI在弥漫性轴索损伤慢性期的应用价值[J]. 山东大学学报(医学版), 2010, 48(2): 146-149. LIU Hepeng, LI Chuanfu, YU Congxin, et al. Application values of SWI and DTI in the chronic stage of diffuse axonal injury [J]. Journal of Shandong University(Health Sciences), 2010, 48(2): 146-149.
[10] Pelekanos V, Mok RM, Joly O, et al. Rapid event-related, BOLD fMRI, non-human Primates(NHP): choose two out of three [J]. Sci Rep, 2020, 10(1): 7485.
[11] Smitha KA, Akhil Raja K, Arun KM, et al. Resting state fMRI: a review on methods in resting state connectivity analysis and resting state networks [J]. Neuroradiol J, 2017, 30(4): 305-317.
[12] 熊志勇, 邓天齐, 李娜. 一种多模态的脑肿瘤图像分割方法[J]. 中南民族大学学报(自然科学版), 2021, 40(4): 394-402. XIONG Zhiyong, DENG Tianqi, LI Na. A multi-model brain tumor segmentation method[J]. Journal of South-Central University for Nationalities(Natural Science Edition), 2021, 40(4): 394-402.
[13] 陶英群. 从头部立体定向框架到神经外科机器人系统辅助脑深部电刺激术[J]. 中国微侵袭神经外科杂志, 2021, 26(4): 145-147. TAO Yingqun. From stereotactic head frame to robotic neurosurgical system assisted deep brain stimulation [J]. Chinese Journal of Minimally Invasive Neurosurgery, 2021, 26(4): 145-147.
[14] 呼虹宇, 张天鼎, 赵君爽, 等. 神经内镜联合多模态神经导航系统切除无功能性垂体大腺瘤的临床应用[J]. 中国医科大学学报, 2021, 50(8): 1-4. HU Hongyu, ZHANG Tianding, ZHAO Junshuang, et al. Clinical application of neuroendoscopy in resection of large nonfunctional pituitary adenomas under a multimodal neuronavigation system [J]. Journal of China Medical University, 2021, 50(8): 1-4.
[15] 武融青, 王潇, 王美瑶, 等. 术中B超联合神经导航辅助显微手术切除脑功能区及脑深部病变[J]. 中国临床神经外科杂志, 2021, 26(7): 501-504. WU Rongqing, WANG Xiao, WANG Meiyao, et al. Application of intraoperative B- mode ultrasound combined with neuronavigation in microsurgery for cerebral cortex and deep brain lesions [J]. Chinese Journal of Clinical Neurosurgery, 2021, 26(7): 501-504.
[16] 樊宇耕, 寇欣. CT影像融合神经导航精准定位下治疗高血压脑出血的临床应用价值[J]. 神经损伤与功能重建, 2021, 16(7): 428-429. FAN Yugeng, KOU Xin. Clinical application value of CT image fusion with neuronavigation in the treatment of hypertensive cerebral hemorrhage with precise localization [J]. Neural Injury and Functional Reconstruction, 2021, 16(7): 428-429.
[17] 王恩运, 吴学谦, 薛莉, 等. 外科手术机器人的国内外发展概况及应用[J]. 中国医疗设备, 2018, 33(8): 115-119. WANG Enyun, WU Xueqian, XUE Li, et al. Development and application of surgical robots at home and abroad [J]. China Medical Devices, 2018, 33(8): 115-119.
[18] 董生, 张晓磊, 李伟, 等. 机器人辅助三叉神经半月节球囊压迫治疗三叉神经痛[J]. 中国疼痛医学杂志, 2021, 27(6): 3. DONG Sheng, ZHANG Xiaolei, LI Wei, et al. Treatment of trigeminal neuralgia with robot-assisted semilunar ganglion balloon compression [J]. Chinese Journal of Pain Medicine, 2021, 27(6): 3.
[19] Waqas M, Shamim MS. Sodium fluorescein guided resection of malignant glioma [J]. J Pak Med Assoc, 2018, 68(6): 968-970.
[20] Belykh E, Cavallo C, Gandhi S, et al. Utilization of intraoperative confocal laser endomicroscopy in brain tumor surgery [J]. J Neurosurg Sci, 2018, 62(6): 704-717.
[21] 许彦龙, 李国强, 余跃, 等. 肿瘤电场治疗在胶质母细胞瘤治疗中的应用进展[J]. 中国医学物理学杂志, 2021, 38(5): 647-649. XU Yanlong, LI Guoqiang, YU Yue, et al. Advances in application of tumor treating fields in glioblastoma [J]. Chinese Journal of Medical Physics, 2021, 38(5): 647-649.
[22] Baskin DS, Sharpe MA, Nguyen L, et al. Case Report: End-stage recurrent glioblastoma treated with a new noninvasive non-contact oncomagnetic device [J]. Front Oncol, 2021, 11: 708017. doi:10.3389/fonc.2021.708017.ecolleation2021.
[23] Cramer SW, Chen CC. Photodynamic therapy for the treatment of glioblastoma [J]. Front Surg, 2020, 6: 81. doi:10.3389/fsurg.2019.00081.
[24] Lipsman N, Meng Y, Bethune AJ, et al. Blood-brain barrier opening in Alzheimer & apos;s disease using MR-guided focused ultrasound [J]. Nat Commun, 2018, 9(1): 2336.
[25] Reulen HJ, Suero Molina E, Zeidler R, et al. Intracavitary radioimmunotherapy of high-grade gliomas: present status and future developments [J]. Acta Neurochir(Wien), 2019, 161(6): 1109-1124.
[26] Rutka JT, Kim B, Etame A, et al. Nanosurgical resection of malignant brain tumors: beyond the cutting edge [J]. ACS Nano, 2014, 8(10): 9716-9722.
[27] 徐田野, 梁洪生, 姚凯, 等. 增强现实和混合现实技术在神经外科领域的应用[J]. 临床神经外科杂志, 2019, 16(4): 356-359. XU Tianye, LIANG Hongsheng, YAO Kai, et al. Application of augmented reality and mixed reality technology in neurosurgery [J]. Journal of Clinical Neurosurgery, 2019, 16(4): 356-359.
[28] 刘佳, 朱明宇, 陈芳, 等. 基于医学影像智能化分析技术的神经外科精准诊疗研究[J]. 医疗卫生装备, 2018, 39(2): 1-6. LIU Jia, ZHU Mingyu, CHEN Fang, et al. Intelligent analysis technique of medical imaging assisted accurate diagnosis and treatment for neurosurgery [J]. Chinese Medical Equipment Journal, 2018, 39(2): 1-6.
[29] 郑宇新, 朱君明. 脑机接口技术在神经修复中的应用[J]. 国际神经病学神经外科学杂志, 2014, 41(1): 58-61. ZHENG Yuxin, ZHU Junming. Application of brain-computer interface technology in neural repair [J]. Journal of International Neurology and Neurosurgery, 2014, 41(1): 58-61.
[30] 汪芳. 基于强化学习的植入式脑机接口神经信息解码: 算法设计及应用[D]. 杭州: 浙江大学, 2015.
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