山东大学学报 (医学版) ›› 2021, Vol. 59 ›› Issue (9): 37-42.doi: 10.6040/j.issn.1671-7554.0.2021.0966
夏术阶,管延杰
XIA Shujie, GUAN Yanjie
摘要: 近年来,以低强度脉冲式超声波(LIPUS)为代表的机械力治疗手段已被广泛用于康复医学、骨折修复、神经损伤修复、泌尿系统疾病等领域。目前研究表明,LIPUS可能通过激活内源性干细胞参与组织修复,但是机械力如何通过生物链的转化而激活干细胞的具体机制尚不明确,因此对机械力生物链传导过程的进一步探索有助于揭示LIPUS的作用机制并为后续的研究与临床应用提供帮助。
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[1] Harrison A, Lin S, Pounder N, et al. Mode & mechanism of low intensity pulsed ultrasound(LIPUS)in fracture repair [J]. Ultrasonics, 2016, 70: 45-52. [2] Langer MD, Levine V, Taggart R, et al. Pilot Clinical Studies of Long Duration, Low Intensity Therapeutic Ultrasound for Osteoarthritis [J]. Proc IEEE Annu Northeast Bioeng Conf, 2014, 14789673. doi: 10.1109/NEBEC.2014.6972850. [3] Lin G, Reed-Maldonado AB, Lin M, et al. Effects and mechanisms of low-intensity pulsed ultrasound for chronic prostatitis and chronic pelvic pain syndrome [J]. Int J Mol Sci, 2016, 17(7): 1057. [4] de Lucas B, Pérez LM, Bernal A, et al. Ultrasound therapy: experiences and perspectives for regenerative medicine [J]. Genes(Basel), 2020, 11(9): 1086. [5] 郭应禄, 辛钟成, 李辉喜, 等. 迎接生命科学第三次革命 重视微能量医学发展[J]. 北京大学学报(医学版), 2015, 47(4): 559-565. [6] 郭霜, 满江位, 姜春倩, 等. 低强度脉冲超声的生物物理学效应及相关机制的研究进展[J]. 中国医学物理学杂志, 2019, 36(5): 605-609. GUO Shuang, MAN Jiangwei, JIANG Chunqian, et al. Progress in biophysical effects of low-intensity pulsed ultrasound and related mechanisms [J]. Chinese Journal of Medical Physics, 2019, 36(5): 605-609. [7] OBrien WD Jr. Ultrasound-biophysics mechanisms[J]. Prog Biophys Mol Biol, 2007, 93(1-3):212-255. [8] Budhiraja G, Sahu N, Subramanian A. Low-intensity ultrasound upregulates the expression of cyclin-D1 and promotes cellular proliferation in human mesenchymal stem cells [J]. Biotechnol J, 2018, 13(4): e1700382. [9] Sato M, Nagata K, Kuroda S, et al. Low-intensity pulsed ultrasound activates integrin-mediated mechanotransduction pathway in synovial cells [J]. Ann Biomed Eng, 2014, 42(10): 2156-2163. [10] Choi BH, Choi MH, Kwak MG, et al. Mechanotransduction pathways of low-intensity ultrasound in C-28/I2 human chondrocyte cell line [J]. Proc Inst Mech Eng Part H J Eng Med, 2007, 221(5): 527-535. [11] Qiu Z, Guo J, Kala S, et al. The mechanosensitive ion channel Piezo1 significantly mediates in vitro ultrasonic stimulation of neurons [J]. iScience, 2019, 21: 448-457. [12] Gao Q, Cooper PR, Walmsley AD, et al. Role of piezo channels in ultrasound-stimulated dental stem cells [J]. J Endod, 2017, 43(7): 1130-1136. [13] Mortimer AJ, Dyson M. The effect of therapeutic ultrasound on calcium uptake in fibroblasts [J]. Ultrasound Med Biol, 1988, 14(6):499-506. [14] Plaksin M, Shoham S, Kimmel E. Intramembrane cavitation as a predictive bio-piezoelectric mechanism for ultrasonic brain stimulation [J]. Physical Review X, 2013, 4(1). doi:10.1103/physRevX.4.011004. [15] Baker KG, Robertson VJ, Duck FA. A review of therapeutic ultrasound: biophysical effects [J]. Phys Ther, 2001, 81(7): 1351-1358. [16] Lehmann JF. The biophysical basis of biologic ultrasonic reactions with special reference to ultrasonic therapy. Arch. Phys [J]. Med. Rehabil, 1953, 34(3):139-152. [17] Lehmann JF, Warren CG, Scham SM. Therapeutic Heat and Cold [J]. Clin Orthop Relat Res, 1974(99): 207-245. doi:10.1097/00003086-197403000-00028. [18] Zhou YF. High intensity focused ultrasound in clinical tumor ablation [J]. World J Clin Oncol, 2011, 2(1): 8-27. doi:10.1097/00003086-197403000-00028. [19] Hannemann PF, Mommers EH, Schots JP, et al. The effects of low-intensity pulsed ultrasound and pulsed electromagnetic fields bone growth stimulation in acute fractures: a systematic review and meta-analysis of randomized controlled trials [J]. Arch Orthop Trauma Surg, 2014, 134(8): 1093-1106. [20] Jiang X, Savchenko O, Li Y, et al. A review of low-intensity pulsed ultrasound for therapeutic applications [J]. IEEE Trans Biomed Eng, 2019, 66(10): 2704-2718. [21] Kumagai K, Takeuchi R, Ishikawa H, et al. Low-intensity pulsed ultrasound accelerates fracture healing by stimulation of recruitment of both local and circulating osteogenic progenitors [J]. J Orthop Res, 2012, 30(9): 1516-1521. [22] Wei FY, Leung KS, Li G, et al. Low intensity pulsed ultrasound enhanced mesenchymal stem cell recruitment through stromal derived factor-1 signaling in fracture healing [J]. PLoS One, 2014, 9(9): e106722. [23] Cui JH, Park K, Park SR, et al. Effects of low-intensity ultrasound on chondrogenic differentiation of mesenchymal stem cells embedded in polyglycolic acid: an in vivo study [J]. Tissue Eng, 2006, 12(1): 75-82. [24] Lai CH, Chen SC, Chiu LH, et al. Effects of low-intensity pulsed ultrasound, dexamethasone/TGF-beta1 and/or BMP-2 on the transcriptional expression of genes in human mesenchymal stem cells: chondrogenic vs. osteogenic differentiation [J]. Ultrasound Med Biol, 2010, 36(6): 1022-1033. [25] Schumann D, Kujat R, Zellner J, et al. Treatment of human mesenchymal stem cells with pulsed low intensity ultrasound enhances the chondrogenic phenotype in vitro [J]. Biorheology, 2006, 43(3-4): 431-443. [26] Xia P, Wang X, Qu Y, et al. TGF-β1-induced chondrogenesis of bone marrow mesenchymal stem cells is promoted by low-intensity pulsed ultrasound through the integrin-mTOR signaling pathway[J]. Stem Cell Res Ther, 2017, 8(1):281. [27] Kusuyama J, Bandow K, Shamoto M, et al. Low intensity pulsed ultrasound(LIPUS)influences the multilineage differentiation of mesenchymal stem and progenitor cell lines through ROCK-Cot/Tpl2-MEK-ERK signaling pathway [J]. J Biol Chem, 2014, 289(15): 10330-10344. [28] Carina V, Costa V, Raimondi L, et al. Effect of low-intensity pulsed ultrasound on osteogenic human mesenchymal stem cells commitment in a new bone scaffold [J]. J Appl Biomater Funct Mater, 2017, 15(3): e215-e222. [29] Mourad PD, Lazar DA, Curra FP, et al. Ultrasound accelerates functional recovery after peripheral nerve damage [J]. Neurosurgery, 2001, 48(5): 1136-1140. [30] Crisci AR, Ferreira AL. Low-intensity pulsed ultrasound accelerates the regeneration of the sciatic nerve after neurotomy in rats [J]. Ultrasound Med Biol, 2002, 28(10):1335-1341. [31] Jiang W, Wang Y, Tang J, et al. Low-intensity pulsed ultrasound treatment improved the rate of autograft peripheral nerve regeneration in rat [J]. Sci Rep, 2016, 6: 22773. doi:10.1038/srep22773. [32] Schuhfried O, Vukanovic D, Kollmann C, et al. Effects of pulsed ultrasound therapy on sensory nerve conduction parameters and the pain threshold perceptions in humans [J]. PM R, 2017, 9(8): 781-786. [33] Lv Y, Nan P, Chen G, et al. In vivo repair of rat transected sciatic nerve by low-intensity pulsed ultrasound and induced pluripotent stem cells-derived neural crest stem cells [J]. Biotechnol Lett, 2015, 37(12): 2497-2506. [34] Lv Y, Zhao PC, Chen GB, et al. Effects of low-intensity pulsed ultrasound on cell viability, proliferation and neural differentiation of induced pluripotent stem cells-derived neural crest stem cells [J]. Biotechnol Lett, 2013, 35(12): 2201-2212. [35] Xia B, Zou Y, Xu Z, et al. Gene expression profiling analysis of the effects of low-intensity pulsed ultrasound on induced pluripotent stem cell-derived neural crest stem cells [J]. Biotechnol Appl Biochem, 2017, 64(6): 927-937. [36] Xia B, Chen G, Zou Y, et al. Low-intensity pulsed ultrasound combination with induced pluripotent stem cells-derived neural crest stem cells and growth differentiation factor 5 promotes sciatic nerve regeneration and functional recovery [J]. J Tissue Eng Regen Med, 2019, 13(4): 625-636. [37] Salonia A, Bettocchi C, Boeri L, et al. European association of urology guidelines on sexual and reproductive health-2021 update: male sexual dysfunction [J]. Eur Urol, 2021, 80(3): 333-357. [38] Yafi FA, Jenkins L, Albersen M, et al. Erectile dysfunction[J]. Nat Rev Dis Primers, 2016, 2: 16003. doi:10.1038/nrdp.2016.3. [39] Lei H, Xin H, Guan R, et al. Low-intensity pulsed ultrasound improves erectile function in streptozotocin-induced type I diabetic rats [J]. Urology, 2015, 86(6): 1241. [40] Peng D, Yuan H, Liu T, et al. Smooth muscle differentiation of penile stem/progenitor cells induced by microenergy acoustic pulses in vitro [J]. J Sex Med, 2019, 16(12): 1874-1884. [41] Cui W, Li H, Guan R, et al. Efficacy and safety of novel low-intensity pulsed ultrasound(LIPUS)in treating mild to moderate erectile dysfunction: a multicenter, randomized, double-blind, sham-controlled clinical study [J]. Transl Androl Urol, 2019, 8(4): 307-319. [42] 夏术阶, 陈辉熔, 李铮, 等. 低强度脉冲超声机械力不同频次治疗勃起功能障碍有效性及安全性观察[J]. 中华医学杂志, 2020, 100(18): 1432-1436. XIA Shujie, CHEN Huirong, LI Zheng, et al. Efficacy and safety of low-intensity pulsed ultrasound at different intervals by mechanical force in treating erectile dysfunction: a preliminary study [J]. Chinese Medical Journal, 2020, 100(18): 1432-1436. [43] Ladegaard PBJ, Mortensen J, Skov-Jeppesen SM, et al. Erectile dysfunction a prospective randomized placebo-controlled study evaluating the effect of low-intensity extracorporeal shockwave therapy(LI-ESWT)in men with erectile dysfunction following radical prostatectomy [J]. Sex Med, 2021, 9(3): 100338. [44] Scroppo FI, Pezzoni F, Gaeta F, et al. Li-Eswt improves hemodynamic parameters thus suggesting neoangiogenesis in patients with vascular erectile dysfunction [J]. Int J Impot Res, 2021. doi:10.1038/s41443-021-00411-0. [45] Qiu X, Lin G, Xin Z, et al. Effects of low-energy shockwave therapy on the erectile function and tissue of a diabetic rat model [J]. J Sex Med, 2013, 10(3): 738-746. [46] Lin G, Reed-Maldonado AB, Wang B, et al. In situ activation of penile progenitor cells with low-intensity extracorporeal shockwave therapy [J]. J Sex Med, 2017, 14(4): 493-501. [47] Aicher WK, Hart ML, Stallkamp J, et al. Towards a treatment of stress urinary incontinence: application of mesenchymal stromal cells for regeneration of the sphincter muscle [J]. J Clin Med, 2014, 3(1): 197-215. [48] Klein G, Hart ML, Brinchmann JE, et al. Mesenchymal stromal cells for sphincter regeneration [J]. Adv Drug Deliv Rev, 2015, 82-83: 123-136. doi:10.1016/j.addr.2014.10.026. [49] Yang B, Li M, Lei H, et al. Low intensity pulsed ultrasound influences the myogenic differentiation of muscle satellite cells in a stress urinary incontinence rat model [J]. Urology, 2019, 123: 297. doi:10.1016/j.urology.2018.09.020. [50] Wang HS, Oh BS, Wang B, et al. Low-intensity extracorporeal shockwave therapy ameliorates diabetic underactive bladder in streptozotocin-induced diabetic rats [J]. BJU Int, 2018, 122(3): 490-500. [51] Xu Y, Guan R, Lei H, et al. Therapeutic potential of adipose-derived stem cells-based micro-tissues in a rat model of postprostatectomy erectile dysfunction [J]. J Sex Med, 2014, 11(10): 2439-2448. [52] Lin G, Yang R, Banie L, et al. Effects of transplantation of adipose tissue-derived stem cells on prostate tumor [J]. Prostate, 2010, 70(10): 1066-1073. [53] Ning GZ, Song WY, Xu H, et al. Bone marrow mesenchymal stem cells stimulated with low-intensity pulsed ultrasound: Better choice of transplantation treatment for spinal cord injury: treatment for SCI by LIPUS-BMSCs transplantation [J]. CNS Neurosci Ther, 2019, 25(4): 496-508. [54] Amini A, Chien SF, Bayat M. Impact of ultrasound therapy on stem cell differentiation - a systematic review [J]. Curr Stem Cell Res Ther, 2020, 15(5): 462-472. |
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