山东大学学报 (医学版) ›› 2018, Vol. 56 ›› Issue (5): 13-17.doi: 10.6040/j.issn.1671-7554.0.2018.220
• • 上一篇
张颖1,杨佳欣1,曹冬焱1,俞梅1,沈铿1,黄惠芳1,潘凌亚1,吴鸣1,郎景和1,游燕2
ZHANG Ying1, YANG Jiaxin1, CAO Dongyan1, YU Mei1, SHEN Keng1, HUANG Huifang1, PAN Lingya1, WU Ming1, LANG Jinghe1, YOU Yan2
摘要: 目的 探讨保留生育功能手术(FSS)治疗早期上皮性卵巢癌(EOC)的可行性及影响患者预后和生育状况的因素。 方法 回顾性分析接受FSS治疗的EOC患者38例,记录年龄、初次手术方式、病理类型、组织学分级、临床分期及初治后是否化疗等可能影响因素,对其术后生存、复发及妊娠生育情况进行分析。 结果 中位随访时间90.5个月。5年总体生存率97%,5年无进展生存率80%。随访期间复发率28.9%。组织学分级(G2/G3)是影响无进展生存期的惟一独立危险因素(χ2=39.36, P<0.001);ⅠA期和ⅠC1/ⅠC2期患者的总体生存率及无进展生存率差异无统计学意义(P>0.05);治疗后有生育条件的患者妊娠率为62.5%,活产率40.6%。术后妊娠率不受年龄、手术方式、临床分期、初治后是否化疗和是否复发等因素影响。 结论 FSS可用于早期EOC患者,其总体肿瘤预后及妊娠状况较好,组织学分级是影响生存及复发的高危因素。
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