山东大学学报 (医学版) ›› 2018, Vol. 56 ›› Issue (1): 32-37.doi: 10.6040/j.issn.1671-7554.0.2017.1094
• • 上一篇
朱久俊,焦得闯,乔江华,王丽娜,马有钊,阳跃,卢振铎,刘真真
ZHU Jiujun, JIAO Dechuang, QIAO Jianghua, WANG Lina, MA Youzhao, YANG Yue, LU Zhenduo, LIU Zhenzhen
摘要: 目的 探讨新辅助化疗(NAC)后乳腺病理完全缓解(pCR)患者腋窝转移的风险及意义。 方法 回顾性连续收集2014年3月5日至2017年7月21日在河南省肿瘤医院乳腺科接受NAC的原发乳腺癌病例资料701例。采用χ2检验比较腋窝pCR(apCR)与临床病理特征及乳腺pCR(bpCR)的关系,应用Logistic回归分析各个变量与apCR的关联性。 结果 淋巴结分期、雌激素受体(ER)、人类表皮生长因子受体2(HER2)是apCR的独立预测因素。bpCR组中HER2阳性、cN0患者93%腋窝没有转移,基底样型(BL)、cN0组7例中的6例腋窝达到pCR,cN1组apCR率达67%;而在Luminal A&B型组患者中,cN0组apCR分别有3、17例(60%、40%),cN1组分别有8、20例(47%、27%)。未bpCR组NAC后腋窝转移风险比bpCR组高4.53倍。 结论 NAC后bpCR与腋窝转移有高度关联性,HER2阳性的cN0/1患者和BL型cN0患者,NAC后如达到bpCR,其腋窝转移风险较低。
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