雷公藤多苷短程治疗对桥本病甲状腺组织T细胞亚群的影响

doi:10.6040/j.issn.1671-7554.0.2013.736

山东大学学报（医学版） ›› 2014, Vol. 52 ›› Issue (3): 86-89.doi: 10.6040/j.issn.1671-7554.0.2013.736

雷公藤多苷短程治疗对桥本病甲状腺组织T细胞亚群的影响

牛瑞芳1，张春玲2，翟亚萍3，马跃华3，李晓玲3，赵志刚3

1．郑州大学第一附属医院内分泌科，河南郑州 450052； 2．河南财经政法大学外国语言文学系，
河南郑州 450002； 3．河南省人民医院东院内分泌科，河南郑州 450003

收稿日期:2013-11-29 出版日期:2014-03-10 发布日期:2014-03-10
通讯作者: 赵志刚。 E-mail:zhaozhigang1957@126.com

Effects of short-term treatment of Tripterygium wilfordii polyglycosidium on T-lymphocyte subsets in thyroid tissue of Hashimoto′s disease

NIU Ruifang1, ZHANG Chunling2, ZHAI Yaping3,MA Yuehua3, LI Xiaoling3, ZHAO Zhigang3

1. Department of Endocrinology, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052， Henan,China;
2. Department of Foreign Languages and Literatures, Henan University of Economics and Laws,
Zhengzhou 450002， Henan,China;
3. Department of Endocrinology, East Hospital, People′s Hospital of Henan Province, Zhengzhou 450003, Henan, China

Received:2013-11-29 Online:2014-03-10 Published:2014-03-10

摘要/Abstract

摘要：

目的观察雷公藤多苷(TWP)短期治疗对桥本病甲状腺组织中T细胞亚群等免疫学指标的影响。方法 60例桥本病患者随机平均分为2组，对照组根据甲状腺功能选用左旋甲状腺素钠或赛治治疗；雷公藤多苷组在对照组的基础上加服TWP。观察随访3个月，比较两组甲状腺组织中T细胞亚群：总T淋巴细胞(CD3+)、调节性T细胞(Treg细胞)(CD4+CD25+)、辅助性T细胞(Th细胞)(CD3+CD4+)、总B淋巴细胞(CD3-CD19+)、细胞毒T淋巴细胞(CD3+CD8+)百分比变化，淋巴细胞的浸润程度及外周血甲状腺球蛋白抗体(TG-Ab)、甲状腺过氧化物酶抗体(TPO-Ab)、促甲状腺激素受体抗体(TRAb)水平的差异。结果雷公藤多苷组：①甲状腺组织中CD3+总T淋巴细胞、CD3+CD4+辅助性T细胞较治疗前下降(P均<0.05)，低于对照组(P均<0.05)；CD3+CD8+细胞毒T淋巴细胞、CD4+CD25+调节性T细胞较治疗前升高(P均<0.05)，高于对照组(P均<0.05)。②甲状腺组织内重度淋巴细胞浸润例数较治疗前明显下降(P<0.05)，低于对照组(P<0.05)；③外周血TRAb转阴患者数较治疗前显著增高(P<0.05)，高于对照组(P<0.05)；TG-Ab及TPO-Ab的水平较治疗前明显下降(P<0.05)，低于对照组(P均<0.05)。结论 TWP短期治疗对桥本病甲状腺组织中T细胞亚群的分布有显著的调节作用，同时能降低甲状腺组织中淋巴细胞的浸润及自身免疫性抗体的水平。

关键词: 桥本病, 雷公藤多苷, 自身抗体, T细胞亚群, 淋巴细胞浸润

Abstract:

Objective To observe the effects of short-term treatment of Tripterygium wilfordii polyglycosidium (TWP) on T-lymphocyte subsets in thyroid tissue of Hashimoto′s disease. Methods A total of 60 patients with Hashimoto′s disease were randomly divided into 2 groups: the control group (n=30) receiving levothyroxine sodium or thyrozol, and the TWP group (n=30) treated with TWP besides levothyroxine sodium or thyrozol. After 3-month treatment, the changes of T-lymphocyte subsets were observed and compared, including the total T-lymphocytes (CD3+), regulatory T cells (CD4+CD25+), helper T-cell (CD3+CD4+), total B-lymphocytes (CD3-CD19+), cytotoxic T lymphocytes (CD3+CD8+), the degree of lymphocytic infiltrates, TG-Ab, TPO-Ab and TRAb. Results After the treatment of TWP, the numbers of CD3+ T cells and CD3+CD4+ Treg cells reduced (P<0.05), and were significantly lower than those of the control group after treatment (P<0.05); the numbers of CD4+CD25+ regulatory T cells and CD3+CD8+ cytotoxic T lymphocytes increased (P<0.05), and were significantly higher than those of the control group after treatment (P<0.05). Lymphocyte infiltration in the thyroid reduced (P<0.05), and was less than that of the control group (P<0.05). Three kinds of antibodies of the TWP group had declined more significantly than those of the control group (P<0.05). Conclusion TWP short-term treatment has obvious immunomodulatory effects on improving the distribution of T-lymphocyte subsets, lymphocyte infiltration and autoimmune thyroid antibodies.

Key words: Hashimoto′s disease, T-lymphocyte subsets, Tripterygium wilfordii polyglycosidium, Lymphocyte infiltration, Autoantibody

中图分类号:

R581.4

牛瑞芳1，张春玲2，翟亚萍3，马跃华3，李晓玲3，赵志刚3 . 雷公藤多苷短程治疗对桥本病甲状腺组织T细胞亚群的影响[J]. 山东大学学报（医学版）, 2014, 52(3): 86-89.

NIU Ruifang1, ZHANG Chunling2, ZHAI Yaping3,MA Yuehua3, LI Xiaoling3, ZHAO Zhigang3. Effects of short-term treatment of Tripterygium wilfordii polyglycosidium on T-lymphocyte subsets in thyroid tissue of Hashimoto′s disease[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2014, 52(3): 86-89.

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雷公藤多苷短程治疗对桥本病甲状腺组织T细胞亚群的影响

Effects of short-term treatment of Tripterygium wilfordii polyglycosidium on T-lymphocyte subsets in thyroid tissue of Hashimoto′s disease

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