关键词: 肝脏硬度, 慢性乙型肝炎, 瞬时弹性波检测, 肝纤维化, 肝硬化

Abstract:

Objective  To explore the evaluation effect and analyze the influential factors of Fibroscan (FS) detection in the progress of patients with chronic hepatitis B disease. Methods  Six hundred and sixty patients with chronic hepatitis B disease were detected with Fibroscan and their clinical data were collected, and 96 of them had liver biopsy Results  . Influences of various clinical indicators on FS values were analyzed. The 96 cases were grouped based on their fibrosis stage in biopsy, the receiver-operating characteristic curves (ROC) of FS values were drawn and the areas under the curve (AUC) were calculated. Results  Multiple clinical indexes, such as age, gender, PLT, PTA, ALT, TBIL, the inner diameter of portal vein and thickness of spleen were associated with FS value, and their differences between different levels had statistical significance(P<0.05). Multiple linear stepwise regression analysis showed that ALT, PTA, thickness of spleen, the inner diameter of portal vein, PLT and TBIL were correlated with FS value. According to the absolute value of the standard regression coefficient, the influence of these indicators on FS value decreased gradually. The AUCs of FS detection for 18 cases of mild (S1), 39 cases of moderate (S2), 12 cases of severe (S3) degree liver fibrosis and 27 cases of cirrhosis (S4) were 0.724, 0.832, 0.836 and 0.798, respectively, and the cut-off values for diagnosis of various degree of fibrosis and cirrhosis were 9.8, 10.5, 12.3 and 14.8 kPa, respectively. Conclusion  Fibroscan detection has a high coincidence rate with liver pathological fibrosis stage. It is a very effective and noninvasive examination in assessing disease progression of patients with chronic hepatitis B disease.

Key words: Liver stiffness;Chronic hepatitis B, Fibroscan, Liver fibrosis, Liver cirrhosis