针刺脑功能磁共振成像的可重复性研究

山东大学学报(医学版) ›› 2013, Vol. 51 ›› Issue (7): 45-49.

针刺脑功能磁共振成像的可重复性研究

何敬振1，侯照成2，张华3，马祥兴1，王青1

1.山东大学齐鲁医院放射科，济南 250012； 2.济南钢铁集团有限公司总医院，济南 250101；
3.山东省医学科学院基础医学研究所，济南 250062

收稿日期:2013-03-24 出版日期:2013-07-10 发布日期:2013-07-10
通讯作者: 马祥兴， E-mail：maxiangxing@yahoo.com.cn
基金资助:
山东省优秀中青年科学家科研奖励基金(26010104021072)

Reproducibility study of fMRI results in acupuncture stimulation

HE Jing-zhen1, HOU Zhao-cheng2, ZHANG Hua3, MA Xiang-xing1, WANG Qing1

1. Department of Radiology, Qilu Hospital of Shandong University, Jinan 250012, China;
2. Gengral Hospital of Jinan Iron and Steel Group Co., Ltd.， Jinan 250101, China;
3. Institute of Basic Medicine, Shandong Medical Sciences Academy, Jinan 250062, China

Received:2013-03-24 Online:2013-07-10 Published:2013-07-10

摘要/Abstract

摘要：

目的探讨功能性磁共振成像(fMRI)针刺引起的脑功能活动区域信号变化的可重复性。方法选择无任何中枢神经系统症状及体征的健康志愿者12名(针刺组)，利用fMRI技术分别针刺足三里穴(ST36)、太溪穴(KI3)及非穴位对照点进行5次完全相同的功能磁共振扫描，以右手对指运动作为对照组，通过计算组内相关系数来对比针刺与对指运动fMRI的可重复性。结果 12名志愿者中，10名完成了全部扫描过程，对数据完整的10名志愿者的数据进行分析。针刺足三里穴(ST36)、太溪穴(KI3)，针刺组中脑功能区活动平均信号变化有着相似的模式，针刺非穴位点引起的脑功能区激活模式与针刺上述两穴位点明显不同；定量比较对指运动及针刺三点引起的脑功能信号变化的可重复性，对照组组内相关系数明显高于针刺组(P<0.05)。结论与对指运动对照组比较，针刺fMRI引起的脑功能活动区域信号变化可重复性较差。

关键词: 针刺；功能性磁共振成像；穴位；可重复性

Abstract:

Objective To test the reproducibility of functional Magnetic Resonance Imaging (fMRI) signal changes evoked by acupuncture stimulation. Methods Twelve volunteers without any sign of the central nervous system and symptom were included in our studies. Twelve subjects participated in five identical scanning sessions with electro acupuncture stimulation at ST36, KI3 and nonacupoint (NP). The finger tapping of right hand was referred as control.To evaluate the reproducibility across different individuals and experimental sessions, an intraclass correlation coefficient (ICC) was analyed. Results Of the twelve volunteers who consented into the study, ten completed all five sessions.The signal changes had similar pattern during acupuncture at ST36 and KI3, which was significantly different from the nonacupoint stimulation.ICC analysis revealed that BOLD signal changes by electroacupuncture stimulation were significantly more variable than those from the control fingertapping task(P<0.05). Conclusion The reproducibility of BOLD signal changes by electroacupuncture was significantly lower than that from the control fingertapping task.

Key words: Acupuncture; Functional magnetic resonance imaging; Acupoint; Reproducibility

中图分类号:

R816.1

何敬振1，侯照成2，张华3，马祥兴1，王青1. 针刺脑功能磁共振成像的可重复性研究[J]. 山东大学学报(医学版), 2013, 51(7): 45-49.

HE Jing-zhen1, HOU Zhao-cheng2, ZHANG Hua3, MA Xiang-xing1, WANG Qing1. Reproducibility study of fMRI results in acupuncture stimulation[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2013, 51(7): 45-49.

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