关键词: 神经管畸形；脂肪酸结合蛋白2基因；脂联素基因；解偶联蛋白2基因；基因多态性

Abstract:

Objective   To find out some susceptible risk factors and explore the roles of multifactors in the high incidence of neural tube defects (NTDs) in Guizhou province of China. Methods   A 1∶1 casecontrol study was conducted on 63 cases who had NTDs infants and 63 cases who had healthy infants. PCR-RFLP was used to detect the polymorphisms of FABP2 A54T, APM1 T45G, and UCP2 A55V. The data were analyzed by SPSS 16.0 statistical software． Results   The distributions of FABP2 A54T gene between the NTDs and control groups had significant differences (P＜0.05), but the distributions of APM1 T45G and UCP2 A55V genes between the two groups had no significant differences (P＞0.05). Multivariate conditional Logistic regression analysis showed that the following four factors were correlated with NTDs：vomiting during pregnancy (OR＝3.56, 95％CI: 1.17-10.87), passive smoking (OR＝3.36, 95％CI: 1.17-9.71), germinated potato intake (OR＝5.80, 95％CI: 1.17-28.78), and FABP A54T mutation (OR＝2.41, 95％CI: 1.13-5.13)． Conclusion   The results suggested that the FABP2 A54T polymorphism, vomiting during pregnancy, germinated potato intake and passive smoking are associated with NTDs．

Key words:  Neural tube defects; Fatty acidbinding protein 2; Adiponectin gene 1; Uncoupling protein 2; Polymorphism