H型高血压患者血浆同型半胱氨酸、硫化氢水平与脑循环动力学的相关性

山东大学学报(医学版) ›› 2013, Vol. 51 ›› Issue (2): 57-60.

H型高血压患者血浆同型半胱氨酸、硫化氢水平与脑循环动力学的相关性

赵乾1，刘蕊2，徐振兴1，朱世明1

1.山东大学附属济南市中心医院心内科，济南 250063；2.济南长虹医院，济南 250011

收稿日期:2012-08-24 出版日期:2013-02-10 发布日期:2013-02-10
通讯作者: 朱世明（1958-），男，博士，教授，硕士生导师，主要从事高血压病靶器官损害与保护的基础、临床及干预研究。E-mail: zsm0322@hotmail.com
作者简介:赵乾（1986- ），女，硕士研究生，主要从事H型高血压与脑循环动力学基础及临床研究。E-mail:moyer1518@yahoo.cn

Correlations between levels of plasma homocysteine and hydrogen sulfide and cerebral circulation dynamics in H type hypertension patients

ZHAO Qian1, LIU Rui2, XU Zhen-xing1, ZHU Shi-ming1

1. Department of Cardiology, Jinan Central Hospital Affiliated to Shandong University, Jinan 250063, China;
2. Jinan Changhong Hospital, Jinan 250011,China

Received:2012-08-24 Online:2013-02-10 Published:2013-02-10

摘要/Abstract

摘要：

目的探讨H型高血压患者血浆同型半胱氨酸（Hcy）、硫化氢（H2S）水平与脑循环动力学的相关性。方法实验组104例高血压患者根据血浆Hcy水平分为H型高血压组（n=59例）和高血压组(n=45例)，正常对照组32例。采用特定蛋白仪及硫敏感电极检测血浆Hcy和H2S水平；采用脑循环动力学检测仪检测脑血管血流动力学参数；采用全自动免疫分析仪检测血浆叶酸及维生素B12水平。结果与正常对照组和高血压组比较，H型高血压组患者血浆H2S、叶酸及维生素B12水平显著降低（P<0.05）。实验组患者脑循环动力学参数显著异常（P<0.001）。相关分析显示，H型高血压组血浆Hcy水平与H2S、叶酸及维生素B12水平呈负相关性 (P<0.05)；与颈动脉平均血流速度（Vmean）及颈动脉平均血流量（Qmean）呈负相关性(P<0.05)；与脑血管外周阻力（Rv）、脑血管特性阻抗（Zc）及动态阻力（DR）呈正相关性（P<0.05）。实验组血浆H2S水平与Qmean呈正相关性（P<0.05），与Rv呈负相关性（P<0.05）。多元线性回归分析显示，Qmean与血浆Hcy水平具有数量依存关系，血浆Hcy升高是脑循环血流量减低的独立影响因素；Rv与血浆H2S水平具有数量依存关系，血浆H2S水平降低是脑血管阻力增加独立影响因素。结论 H型高血压患者血浆Hcy、H2S水平变化可影响脑血管生理功能并引起脑血流动力学的异常。

关键词: 同型半胱氨酸；硫化氢；脑循环动力学；H型高血压

Abstract:

Objective To investigate the correlations between plasma homocysteine (Hcy) and hydrogen sulfide (H2S) levels and parameters of cerebral circulation dynamics in H type hypertension patients. Methods 104 patients were graded in H type hypertension group and hypertension group according to the level of plasma Hcy with 32 normal controls as the control group. The levels of plasma Hcy and H2S were measured by specific protein instrument and sulfur sensitive electrode. The parameters of cerebral circulation dynamics were detected by cerebral circulation dynamics detector. The levels of plasma folic acid and vitamin B12 were measured by auto DELFIA analyzer. Results Compared with those of the controls and the hypertension group, the levels of plasma H2S, folic acid and vitamin B12 significant decreased in the H type hypertension group（P<0.05）, and the parameters of cerebral circulation dynamics had significant differences in the experiment group（P<0.001）. The level of plasma Hcy in the H type hypertension group had significantly nagative correlations with H2S, folic acid, vitamin B12, Vmean and Qmean (P<0.05).But it had significantly positive correlations with Rv, Zc and DR (P<0.05). The level of plasma H2S in the experimental group had significantly positive correlations with Qmean (P<0.05) and nagative correlations with Rv (P<0.05). Multiple linear regression analysis revealed a significant and independent association of Qmean with the increasing level of plasma Hcy, as was the association of Rv with the decreasing level of plasma H2S. The increasing level of plasma Hcy was an independent risk factor for the decreasing cerebral blood flow, and the decreasing level of plasma H2S was an independent risk factor for the increasing cerebral vascular resistance. Conclusion Brain vascular physiology function was affected by the levels of plasma Hcy and H2S, which can cause changes of brain hemodynamics in H type hypertension.

Key words: Homocysteine; Hydrogen sulfide; Cerebrovascular hemodynamic; H type hypertension

中图分类号:

R544.1

赵乾1，刘蕊2，徐振兴1，朱世明1. H型高血压患者血浆同型半胱氨酸、硫化氢水平与脑循环动力学的相关性[J]. 山东大学学报(医学版), 2013, 51(2): 57-60.

ZHAO Qian1, LIU Rui2, XU Zhen-xing1, ZHU Shi-ming1. Correlations between levels of plasma homocysteine and hydrogen sulfide and cerebral circulation dynamics in H type hypertension patients[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2013, 51(2): 57-60.

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