关键词: 基因多态性；基质金属蛋白酶-9；心室舒张末期室间隔厚度；舒张末期左心室后壁厚度；动脉内膜中层厚度；左心室质量指数；高血压；踝臂指数；心室重构

Abstract:

Objective   To explore  the relationship between matrix metalloproteinases-9 gene polymorphism and the cardiovascular remodeling in  hypertension patients. Methods   53 hypertension patients were randomly selected. 30 healthy people were selected as the control group. Ventricular end-diastolic interventricular septum (IVSTd), end-diastolic left ventricular wall thickness(LVPWTd) and carotid intima media thikness(IMT) were determined by Doppler ultrasonography. The blood pressure of upper and lower limbs was measured and the ABI was calculated. The C-1562T gene polymorphism of MMP-9 was measured by polymerase chain  reaction combined with restriction enzyme digestion. Results   MMP-9 gene polymorphism was not associated with the onset and development of hypertension（P>0.05）；IVSTd, LVPWTd and IMT of hypertension patients who carried the T alleles was thicker than that of the hypertension patients who didn’t carry the T alleles(P<0.05)；ABI of hypertension patieints who carried the T alleles was lower than that of the patients who didn’t carry the T alleles；The C-1562T gene polymorphism of the hypertension patients was positively correlated with the IVSTd, LVPWTd and IMT(P<0.05),and was negatively correlated with the ABI(P<0.05). Age had negative correlations with the ABI in the  hypertension patients. Conclusion   C-1562T gene polymorphism of MMP-9 gene is one of the important factors that effect the cardiovascular remodeling in the hypertension patients.