2型糖尿病合并脑梗死患者血糖水平与PSGL-1的关系及其意义

山东大学学报(医学版) ›› 2013, Vol. 51 ›› Issue (10): 66-69.

2型糖尿病合并脑梗死患者血糖水平与PSGL-1的关系及其意义

张慧凤1，周家龙1，盛文化2，3

1.潍坊医学院神经病学教研室，山东潍坊 261053； 2.山东大学附属济南市中心医院神经内科，济南 250013；
3.华中科技大学同济医学院附属同济医院神经内科，武汉 430030

收稿日期:2013-05-21 出版日期:2013-10-10 发布日期:2013-10-10
通讯作者: 盛文化， E-mail：wh_sheng@yahoo.com.cn

Relationship between blood glucose level and PSGL-1 expression in acute cerebral infarction patients with type 2 diabetes mellitus and its significance

ZHANG Hui-feng1， ZHOU Jia-long1， SHENG Wen-hua2，3

1. Department of Neurology, Weifang Medical University, Weifang 261053, Shandong, China;
2. Department of Neurology, Jinan Central Hospital Affiliated to Shandong University, Jinan 250013, China;
3. Department of Neurology, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of
Science and Technology, Wuhan 430030, China

Received:2013-05-21 Online:2013-10-10 Published:2013-10-10

摘要/Abstract

摘要：

目的探讨老年2型糖尿病合并脑梗死患者血糖水平对P-选择素糖蛋白配体1(PSGL-1)表达的影响及其意义。方法选择70~80岁的住院患者120例，分为3组：2型糖尿病合并急性脑梗死组(DMCI组)、单纯急性脑梗死组(CI组)、单纯2型糖尿病组(DM组)，每组40例，以健康查体者40例为健康对照组(NC组)。用流式细胞仪检测PSGL-1的表达量，常规生化检测糖化血红蛋白、空腹血糖、早餐后2h血糖水平，并对脑梗死患者采用美国国立卫生研究院卒中量表(NIHSS)进行评分。结果 DMCI组、DM组、CI组PSGL-1的表达量(44.57±6.07、41.03±4.34、42.25±4.85)与NC组(33.12±3.72)相比，差异均有统计学意义(P均＜0.05)。相关分析显示，PSGL-1的表达与糖化血红蛋白(r=0.72， P＜0.01)、餐后血糖(r=0.36， P＜0.05)、空腹血糖(r=0.19， P＜0.05)均呈显著正相关。结论 PSGL-1的表达在2型糖尿病合并脑梗死患者中显著增高。血糖水平可以影响PSGL-1的表达，PSGL-1可能是2型糖尿病合并脑梗死患者的一个高危因素且与病情有明显相关性。

关键词: P-选择素糖蛋白配体1；血糖水平；急性脑梗死；2型糖尿病；老年

Abstract:

Objective To explore the influence and significance of blood glucose level on PSGL-1 expression in acute cerebral infarction patients with type 2 diabetes mellitus. Methods One hundred and twenty subjects who were 70 to 80 years old were divided evenly into 3 groups: acute cerebral infarction with type 2 diabetes mellitus group(DMCI group), acute cerebral infarction group(CI group), diabetes group(DM group). Forty people who had a physical examination were taken as healthy control group(NC group). Flow cytometry was used to measure the expression of PSGL-1. The levels of glycosylated haemoglobin A1c, fasting plasma glucose and postprandial blood glucose were detected by conventional biochemical tests. NIHSS scores of all the acute cerebral infarction patients were judged when they were enrolled into hospital. Results The levels of PSGL-1 in DMCI group (44.57±6.07), DM group(41.03±4.34) and CI group(42.25±4.85) were significantly higher than that in NC group (33.12±3.72)(all P<0.05). The level of PSGL-1 was positively related with glycosylated haemoglobin A1c(r=0.72, P<0.01), postprandial blood sugar(r=0.36, P<0.05) and fasting plasma glucose(r=0.19, P<0.05). Conclusion The level of PSGL-1 increases significantly in acute cerebral infarction patients with type 2 diabetes mellitus. There are significant correlations between PSGL-1 and blood glucose levels. PSGL-1 could be a high risk factor in acute cerebral infarction of patients with type 2 diabetes mellitus and significantly relates to the changes of patients′condition.

Key words: P-selectin glycoprotein ligand 1; Blood glucose levels; Acute cerebral infarction; Type 2 diabetes mellitus; Old age

中图分类号:

R743.32

张慧凤1，周家龙1，盛文化2，3. 2型糖尿病合并脑梗死患者血糖水平与PSGL-1的关系及其意义[J]. 山东大学学报(医学版), 2013, 51(10): 66-69.

ZHANG Hui-feng1， ZHOU Jia-long1， SHENG Wen-hua2，3. Relationship between blood glucose level and PSGL-1 expression in acute cerebral infarction patients with type 2 diabetes mellitus and its significance[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2013, 51(10): 66-69.

参考文献

多维度评价

Viewed

Full text

Abstract

Cited

Shared

Discussed

[1]	王维1, 陈春富1, 许亮1，苏歆1, 李继川1, 张君1, 王国卿2. 腔隙性脑梗死患者抑郁状态相关因素的回归分析[J]. 山东大学学报(医学版), 2011, 49(11): 84-87.
[2]	孙彩凤，张峰，姚庆民，刘彦霞，朱效娟，谢宁，徐健. ADAMTS13与TSP1在老年急性脑梗死中的意义[J]. 山东大学学报(医学版), 2011, 49(11): 88-92.
[3]	陈欢1，朱梅佳2，胥文娟1，马高亭1，赵张宁2. 2型糖尿病脑梗死患者血清MMP-2、VEGF与糖代谢异常的相关性[J]. 山东大学学报(医学版), 2011, 49(1): 23-27.
[4]	赵清1,2,杨丽玲1, 杜怡峰1. 步长脑心通对大鼠急性脑缺血再灌注小胶质细胞炎症反应和神经细胞凋亡的影响[J]. 山东大学学报(医学版), 2010, 48(11): 46-49.
[5]	曲立新1,2，宿少华2，杨丽玲1，李甲龙1，任晓燕1，杜怡峰1. 脑心通对局灶性脑缺血再灌注损伤大鼠的保护作用[J]. 山东大学学报(医学版), 2010, 48(9): 49-.
[6]	宋玉强1，2，毕建忠1. 低频超声辅助尿激酶溶栓对大鼠脑梗死基质金属蛋白酶9的影响[J]. 山东大学学报(医学版), 2009, 47(12): 50-53.