前列腺素受体EP2在溃疡性结肠炎黏膜中的表达及临床意义

山东大学学报(医学版) ›› 2012, Vol. 50 ›› Issue (11): 79-83.

前列腺素受体EP2在溃疡性结肠炎黏膜中的表达及临床意义

李梅1,2,高艳景1,崔祥华1，徐咏梅3

1.山东大学齐鲁医院消化内科，济南 250012； 2.枣庄矿业集团枣庄医院消化内科，山东枣庄 277100；
3.中国人民解放军海军潜艇学院门诊部，山东青岛 266071

收稿日期:2012-04-25 出版日期:2012-11-10 发布日期:2012-11-10
通讯作者: 高艳景(1965- )，男，教授，主要从事消化系统肿瘤及炎症性肠病的基础与临床研究。 E-mail:yanjinggao@yahoo.com.cn
作者简介:李梅(1973- )，女，硕士研究生，主要从事炎症性肠病的基础与临床研究。 E-mail:limei0632@163.com

Expression and clinical significance of EP2 prostanoid receptor in
colon mucosa of ulcerative colitis

LI Mei1,2, GAO Yan-jing1, CUI Xiang-hua1， XU Yong-mei3

1. Department of Gastroenterology， Qilu Hospital of Shandong University， Jinan 250012, China;
2. Department of Gastroenterology, Zaozhuang Hospital, Zaozhuang Mining Group, Zaozhuang 277100, Shandong, China;
3. The Outpatient department of the Chinese People’s Liberation Army Navy Submarine Academy,
Qingdao 266071, Shandong, China

Received:2012-04-25 Online:2012-11-10 Published:2012-11-10

摘要/Abstract

摘要：

目的通过检测溃疡性结肠炎(UC)结肠黏膜前列腺素EP2受体的表达，探讨EP2受体与UC黏膜炎症的关系。方法选取27例活动期UC、11例缓解期UC及23例正常对照者为研究对象。首先对UC患者按Southerland疾病活动指数(UCAI)进行疾病分期及病理学分级，再进行免疫组化检测每例结肠上皮EP2的表达。结果免疫组化表明,活动期UC患者结肠上皮和炎症细胞中EP2的表达均高于UC缓解期及正常结肠黏膜(P＜0.01)，活动期UC患者EP2的表达与病理分级呈正相关。结论 EP2蛋白在活动期UC患者中的表达显著上调，且与炎症程度相关， EP2有可能作为UC治疗的新靶标。

关键词: 溃疡性结肠炎；前列腺素受体EP2；免疫组织化学

Abstract:

Objective To explore the relationship between EP2 and ulcerative colitis (UC) by detecting the expression of EP2 in mucosa of UC. Methods 27 patients with active UC, 11 patients with remissive UC and 23 normal control subjects were recruited into the trial. The ulcerative colitis disease activity index (UCAI) was used to calculate the pathological grade and disease stage. Expressions of EP2 were detected by the immunohistochemistry in colonic tissues of the patients and controls. Results The EP2 protein levels in colonic epithelial and inflammatory cells in the patients with active UC were higher compared with the patients with remissive UC and controls (P＜0.01). In the patients with active UC, EP2 expressions were positively related to the pathological grade. Conclusion Expressions of EP2 were significantly up regulated in the colon mucosa of active UC patients and positively correlated with the inflammation degree，which indicates EP2 may be a new target for the UC treatment.

Key words: Ulcerative colitis; EP2 receptor; Immunohistochemistry

中图分类号:

R574.62

李梅1,2,高艳景1,崔祥华1，徐咏梅3. 前列腺素受体EP2在溃疡性结肠炎黏膜中的表达及临床意义[J]. 山东大学学报(医学版), 2012, 50(11): 79-83.

LI Mei1,2, GAO Yan-jing1, CUI Xiang-hua1， XU Yong-mei3. Expression and clinical significance of EP2 prostanoid receptor in
colon mucosa of ulcerative colitis[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2012, 50(11): 79-83.

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