骨桥蛋白在结直肠腺瘤—癌进程中的表达

山东大学学报(医学版) ›› 2012, Vol. 50 ›› Issue (11): 84-87.

骨桥蛋白在结直肠腺瘤—癌进程中的表达

禹化龙1，胡三元2

山东大学 1.第二医院普外科，济南 250033; 2.齐鲁医院普外科，济南 250012

收稿日期:2012-07-08 出版日期:2012-11-10 发布日期:2012-11-10
通讯作者: 胡三元(1962- ),男,主任医师,博士生导师,主要从事胆道外科、微创外科的研究。
作者简介:禹化龙(1977- ),男，博士研究生,主治医师，主要从事结直肠外科及微创外科的研究。

Expression of osteopontin in the colorectal
adenoma-carcinoma sequence

YU Hua-long1， HU San-yuan2

1. Department of General Surgery, The Second Hospital of Shandong University， Jinan 250033， China
2. Department of General Surgery, Qilu Hospital of Shandong University， Jinan 250012， China

Received:2012-07-08 Online:2012-11-10 Published:2012-11-10

摘要/Abstract

摘要：

目的探讨骨桥蛋白(OPN) 在结直肠腺瘤—癌进程中的表达及其与肠黏膜上皮不典型增生之间的关系。方法应用免疫组织化学法检测60例结直肠正常黏膜上皮组织、50例腺瘤组织及60例结直肠癌组织中OPN的表达。结果 OPN表达在结直肠正常黏膜向癌转化过程中明显增高，正常黏膜组织、腺瘤及癌中OPN表达率分别为3.3%、66%和81.5%。OPN的表达与上皮不典型增生程度相关。结论在结直肠腺瘤—癌进程中，随着上皮细胞不典型增生程度加重，OPN表达水平显著升高，表明OPN可能在上皮向恶性肿瘤转化过程中起到重要作用。

关键词: 骨桥蛋白; 结直肠; 腺瘤—癌进程

Abstract:

Objective To explore the expression of osteopontin (OPN) in the colorectal adenoma-carcinoma sequence, and analyze the relationship with the epithelial dysplastic degree. Methods Expressions of OPN were detected by the immunohistochemistry in 60 cases with normal colorectal epithelia, 50 cases with adenoma and 60 cases with carcinoma. Results During the progression from normal colorectal epithelia to the carcinoma, OPN expressions significantly increased. The positive rates of OPN expressions in normal epithelia, adenoma and carcinoma were 3.3%, 66% and 81.5%. OPN expressions were related with the dysplastic degree of epithelia. Conclusion During the adenoma-carcinoma sequence in the colorectum, OPN expression rates increase with the development of the epithelial dysplasia. OPN may play an important role in the malignant transformation.

Key words: Osteopontin; Colorectum; Adenoma-carcinoma sequence

中图分类号:

R737.35

禹化龙1，胡三元2. 骨桥蛋白在结直肠腺瘤—癌进程中的表达[J]. 山东大学学报(医学版), 2012, 50(11): 84-87.

YU Hua-long1， HU San-yuan2. Expression of osteopontin in the colorectal
adenoma-carcinoma sequence[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2012, 50(11): 84-87.

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