红花黄素对大鼠局灶性脑缺血再灌注损伤的保护作用

山东大学学报(医学版) ›› 2011, Vol. 49 ›› Issue (6): 11-14.

红花黄素对大鼠局灶性脑缺血再灌注损伤的保护作用

张庆1，郑冬雁1，徐红岩2，潘燕1，魏蜀一1

山东大学医学院 1.生物医学工程研究所；2.机能学教研室，济南 250012

收稿日期:2010-12-28 出版日期:2011-06-10 发布日期:2011-06-10
通讯作者: 潘燕(1962- )，女，硕士，副教授，硕导，主要从事生物医学信号的检测与分析的研究。 E-mail：panyan@sdu.edu.cn
作者简介:张庆(1985- )，女，硕士研究生，主要从事生物医学信号的检测与分析的研究。 E-mail：juli99@163.com

Effects of safflor yellow on focal cerebral ischemia-reperfusion injury in rats

ZHANG Qing1， ZHENG Dong-yan1， XU Hong-yan2， PAN Yan1， WEI Shu-yi1

1. Institute of Biomedical Engineering; 2. Department of Functional Science，School of Medicine, Shandong University, Jinan 250012， China

Received:2010-12-28 Online:2011-06-10 Published:2011-06-10

摘要/Abstract

摘要：

目的研究红花黄素对大鼠局灶性脑缺血再灌注损伤(I/R)的保护作用。方法采用线栓法制作大鼠大脑中动脉缺血再灌注模型。插入栓线前、插入栓线0.5h后以及再灌注2h后分别监测肛温、肢体II导联心电、股动脉压以及大脑局部脑血流量。大鼠清醒后，进行行为学评分，测定脑含水量并进行组织病理学检查。结果红花黄素能显著提高缺血再灌注后局部脑血流量，对抗血压与心率变化，降低脑组织含水量，缩小脑梗死面积，减轻缺血所致组织病理改变。结论红花黄素可以增加I/R脑血流量，恢复因缺血造成的自主神经功能损伤，对大鼠局灶性脑缺血再灌注损伤具有保护作用。

关键词: 红花黄素；再灌注损伤；局部血流；平均动脉压；心率

Abstract:

Objective To investigate protective effects of safflor yellow against focal cerebral ischemia-reperfusion injury in rats. Methods Middle cerebral artery occlusion (MCAO) was used to prepare focal cerebral ischemia. Rectal temperature, ECG, femoral arterial pressure and regional cerebral blood flow(rCBF) in each rat were detected before MCAO, 0.5h after occlusion and 2h after reperfusion. Then effects of safflor yellow were studied by determining neurological deficit, water content of brain tissues, cerebral infarcted zone and pathological changes under a microscope. Results Safflor yellow could increase rCBF and reduce mean blood pressure(MBP), heart rate(HR), percentage of the infarction area and water content in the cerebral hemisphere, and it could relieve ischemia-induced pathological changes. Conclusion Safflor yellow can increase rCBF and reduce damage to the autonomic nervous system. It has a protective effect against focal cerebral ischemia-reperfusion injury.

Key words: Safflower yellow pigment; Reperfusion injury; Regional blood flow; Mean arterial pressure; Heart rate

中图分类号:

R961.1

张庆1，郑冬雁1，徐红岩2，潘燕1，魏蜀一1. 红花黄素对大鼠局灶性脑缺血再灌注损伤的保护作用[J]. 山东大学学报(医学版), 2011, 49(6): 11-14.

ZHANG Qing1， ZHENG Dong-yan1， XU Hong-yan2， PAN Yan1， WEI Shu-yi1. Effects of safflor yellow on focal cerebral ischemia-reperfusion injury in rats[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2011, 49(6): 11-14.

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