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山东大学学报(医学版) ›› 2011, Vol. 49 ›› Issue (5): 102-106.

• 论文 • 上一篇    下一篇

腺周肌纤维母细胞标志物在胃癌及癌前病变中的表达

匡荣光1,2,李延青1,周成军3,季锐1,王建文2   

  1. 山东大学 1. 齐鲁医院消化内科, 济南 250012;2. 附属千佛山医院保健科,济南 250014;3. 第二医院病理科, 济南 250033
  • 收稿日期:2010-12-07 出版日期:2011-05-10 发布日期:2011-05-10
  • 通讯作者: 李延青(1962- ),男,教授,博士生导师,主要从事功能性胃肠病和早期消化道肿瘤研究。
  • 作者简介:匡荣光(1975- ),男,博士研究生,主治医师,主要从事早期消化道肿瘤研究。 E-mail:kuangrongguang@163.com

Marker expression  of pericryptal myofibroblasts in gastric carcinoma and precancerous lesions

KUANG Rong-guang1,2, LI Yan-qing1, ZHOU Cheng-jun3, JI Rui1,WANG Jian-wen2   

  1. 1. Department of Gastroenterology, Qilu Hospital of Shandong University, Jinan 250012, China;
     2. Department of Health Care, Qianfoshan Hospital Affiliated to Shandong University, Jinan 250014, China;
     3. Department of Pathology, Second Hospital of Shandong University, Jinan 250033, China
  • Received:2010-12-07 Online:2011-05-10 Published:2011-05-10

摘要:

目的     探讨在胃黏膜癌变演进过程中,间质肌纤维母细胞标志物α平滑肌肌动蛋白(α-SMA)的表达变化及其与增殖细胞核抗原(PCNA)的关系。方法    采用免疫组化方法,检测胃癌及癌前病变中α-SMA和PCNA表达, 并分析它们的相关性。结果    α-SMA表达在肠化生黏膜中升高,低、高级上皮内瘤变表达较肠化黏膜降低,在胃癌中表达再次升高(χ2=56.15,P<0.01)。α-SMA的分布模式亦有差别,肠化生黏膜呈腺周表达模式,向胃癌进展过程中腺周表达模式逐渐弱化。PCNA表达随胃黏膜癌变演进状态的改变逐渐增高(χ2=117.12,P<0.01)。α-SMA与PCNA表达呈显著正相关(rs =0.61,P<0.01)。结论    间质肌纤维母细胞在胃黏膜癌变演进过程中表达强度及分布均存在明显变化,提示其功能具有异质性,参与了胃癌的恶性转化过程。

关键词: 上皮细胞;肌纤维母细胞;胃肿瘤

Abstract:

Objective    To investigate expression change of alpha-smooth muscle actin(α-SMA), the marker of pericryptal myofibroblasts, in gastric carcinoma and precancerous lesions, and study its relationship with the proliferating cell nuclear antigen (PCNA). Methods    The immunohistochemical technique was used to detect expression of α-SMA and PCNA in gastric carcinoma and precancerous lesions. The relationship between α-SMA and PCNA was analyzed. Results    Expression of α-SMA was increased in intestinal metaplasia, then decreased in low or high grade gastric intraepithelial neoplasia, and increased again in gastric carcinoma.(χ2=56.15,P<0.01). The pericryptal distribution of α-SMA was found in intestinal metaplasia, but diminished along with the development of gastric carcinoma. Expression of PCNA was increased along with the development of gastric carcinogenesis (χ2=117.12,P<0.01). There was a positive correlation between α-SMA and PCNA expressions(rs =0.61,P<0.01).  Conclusions     There are significanct changes in expression intensity and distribution of stroma myofibroblasts with the development of gastric carcinoma, which indicates that myofibroblasts might play a role in gastric carcinogenesis.

Key words: Epithelium; Stroma myofibroblast; Stomach neoplasms

中图分类号: 

  • R573
[1] 张琪1,2,李延青1,张翠萍2,赵坤2,孙向红3. 活化诱导胞嘧啶核苷脱氨酶在肠型胃癌组织中的表达及与幽门螺杆菌感染的关系[J]. 山东大学学报(医学版), 2012, 50(12): 61-.
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