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山东大学学报(医学版) ›› 2010, Vol. 48 ›› Issue (9): 5-8.

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用危险因素评分法分析超重及肥胖对糖尿病的影响

李鹏飞1,娄能俊2,刘云台3,辛颖1,廖琳1,董建军4   

  1. 1.山东大学附属省立医院内分泌科, 济南 250021; 2.山东大学第二医院内分泌科, 济南 250033;
    3.济南二机床集团有限公司职工医院, 济南 250101;  4.山东大学齐鲁医院内分泌科, 济南 250012
  • 收稿日期:2010-06-16 出版日期:2010-09-16 发布日期:2010-09-16
  • 通讯作者: 董建军(1965- ),男,副教授,博士,研究方向为糖尿病与甲状腺疾病。 E-mail: dongjianjun@medmail.com.cn
  • 作者简介:李鹏飞(1973- ),男,主治医师,硕士,研究方向为糖尿病肾病。
  • 基金资助:

    山东省科技厅课题(963000052)

Contribution of overweight and obesity to the prevalence rate of diabetes and its other risk factors

LI Peng-fei1, LOU Neng-jun2, LIU Yun-tai3,XIN Ying1, LIAO Lin1, DONG Jian-jun4   

  1. 1. Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, China;
    2. Department of Endocrinology, The Second Hospital of Shandong University, Jinan 250033, China;
    3. The Staff hospital of Jinan JiEr Machine Tool Group Cooperation Limited Company, Jinan 250101, China;
    4. Department of Endocrinology, Qilu Hospital of Shandong University, Jinan 250012, China
  • Received:2010-06-16 Online:2010-09-16 Published:2010-09-16

摘要:

目的    用危险因素评分法评价可干预的危险因素超重及肥胖对糖尿病发病及其他相关危险因素的影响。方法    采用危险因素评分法在对糖尿病危险因素进行流行病学问卷调查的基础上,根据体质量指数(BMI)将人群分为A(超重肥胖)、B(正常)两组,A组2580人,B组2768人。分别对两组人群的糖尿病和糖耐量异常(IGT)的患病率进行统计,并采用非条件logistic回归分析筛选糖尿病的危险因素,根据危险因素的回归系数β值确定不同变量的积分值,以累计积分值的大小判断个体患病的危险性。结果     A组糖尿病的患病率为6.7%,IGT的患病率为17.5%;年龄、糖尿病家族史、腰臀比、收缩压、脉搏、高血糖史等6个因素经筛选成为危险因素变量。B组糖尿病的患病率为1.1%,IGT的患病率为7.0%,年龄、舒张压、糖尿病家族史、高血糖史等4个因素经筛选成为危险因素变量。趋势性χ2检验显示,差异有统计学意义(P<0.001)。结论     超重肥胖人群糖尿病患病率明显高于普通人群。年龄、血压、糖尿病家族史、既往高血糖史是糖尿病发病的独立危险因素。通过测身高、体质量及回答问卷的无创方法,能发现潜在的、易忽略的危险因素,对体质量进行早期干预能够显著减少糖尿病及IGT的发病率。

关键词: 糖尿病;肥胖;超重;危险因素

Abstract:

Objective    To investigate the contributions of overweight and obesity to the prevalence rate of diabetes and its other risk factors on the basis of a questionnaire of the diabetes epidemic survey model. Methods    Based on a questionnaire of epidemiological survey, obese and non-obese target populations were enrolled. According to the body mass index(BMI), the participants were divided into 2 groups: group A (BMI≥24kg/m2) and group B (BMI <24kg/m2). The prevalence rate of diabetes and impaired glucose tolerance(IGT) were calculated. Logistic regression analysis was carried out to screen the primary risk factors of diabetes. The score of the variables was determined by β-coefficients, and used to predict the risk of correlation factors. Results    The prevalence rate of diabetes and IGT were 6.7% and 17.5% in group A, and  1.1% and 7.0% in group B, respectively.  Age, family history of diabetes, waist-hip ratio (WHR), systolic pressure,  pulse, and history of high glucose were singled out as risk factors  in group A. Age, diastolicpressure,family history of diabetes, and history of high glucose were risk factors in group B.  A trend χ2 test yielded a statistical significance (P<0.001). Conclusion    The prevalence rate of diabetes and IGT were much higher in the overweight and obese population than in the nonobese population. Lifestyle modification can control this factor, it is promising to prevent or delay the development of diabetes mellitus and IGT. Age, blood pressure, family history of diabetes, and history of high blood sugar are all independent risk factors for diabetes.

Key words:  Diabetes mellitus; Overweight; Obesity; Risk factors

中图分类号: 

  • R587.1
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