单纯高脂血症患者非药物干预的疗效评价

山东大学学报(医学版) ›› 2010, Vol. 48 ›› Issue (8): 117-119.

单纯高脂血症患者非药物干预的疗效评价

张敏1，2，徐贵发1

1.山东大学公共卫生学院，济南 250012； 2.青岛市市立医院东院区体检中心，山东青岛 266071

收稿日期:2010-05-20 出版日期:2010-08-16 发布日期:2010-08-16
通讯作者: 徐贵发（1948- ），男，教授，博士生导师，主要从事营养与食品卫生学的研究。E-mail：yyxu@sdu.edu.cn
作者简介:张敏（1975- ），女，医师，硕士研究生，主要从事公共卫生、营养学的研究。 E-mail：zmmoon@163.com

Effect of nonpharmacotherapy in decreasing the levels of serum lipid in simple hyperlipidemia patients

ZHANG Min1，2, XU Gui-fa1

1. College of public health of Shandong University, Jinan 250012， China;
2. Medical examination center of Qingdao municipal hospital, Qingdao 266071， Shandong， China

Received:2010-05-20 Online:2010-08-16 Published:2010-08-16

摘要/Abstract

摘要：

目的探讨单纯高脂血症患者行非药物干预的降脂效果。方法将1600例健康体检人员中检出的单纯高脂血症患者197例随机分为干预组99例和对照组98例，干预组给予综合性非药物干预，包括健康宣教、饮食指导、运动处方等，每周进行回访监督，对照组不进行上述干预，不服用降脂药物，在观察期开始及6个月观察期满时,分别采用酶法测定血中甘油三酯（TG）、总胆固醇（TC）和低密度脂蛋白（LDLC）的水平变化，同时测试高脂血症相关知识知晓率、统计平均每周主动锻炼次数、估算平均每天食用油量，测定体质量指数（BMI）并进行统计学分析。结果干预组高脂血症相关知识知晓率、每周主动体育锻炼次数均有明显增加，两者增幅均高于对照组，干预组食油量明显下降，BMI下降，降幅均大于对照组（P＜0.05）。干预组TG从（2.81±1.32）mmol/L降至（2.06±0.91）mmol/L，TC从（6.67±0.93）mmol/L降至（5. 49±0.95）mmol/L ，LDLC从（4.69±0.89）mmol/L降至（3.83±1.02）mmol/L，与对照组相比，P值分别为0.007、0.005、0.006，各指标下降幅度均有统计学差异。而且血脂下降与相关健康知识知晓水平的提高、主动性体育锻炼的增加以及食油摄入量的减少呈明显相关性。结论非药物干预方法对单纯高脂血症患者有一定疗效，可作为单纯高脂血症患者的非药物治疗方法。

关键词: 高脂血症; 非药物干预；健康宣教; 运动疗法; 饮食指导

Abstract:

Objective To investigate a non-pharmacotherapy program for patients with simple hyperlipidemia diagnosed in health examination and assess its effectiveness. Methods 197 patients was divided into two groups randomly: the experimental group (99 cases) and the control group (98 cases). The experimental group was given non-pharmacotherapy once a week and the therapy lasted for 6 weeks. The content of non-pharmacotherapy consisted of: a) teaching related knowledge about hyperlipidemia; b) guiding healthy life-style, such as diet and exercise. Patients were followed up every week. The control group didn′t undergo any non-pharmacotherapy program. A selfcompletion questionnaire on hyperlipidemia-related knowledge, questionnaires on diet and exercise were obtained and serum TG, TC, LDL-C and BMI were measured at entry point and at the end of 6-month study. Results The hyperlipidemia-related knowledge and weekly physical exercise time of experimental group increased while the daily oil intaking and BMI decreased. The mean of serum TG, TC and LDL-C of experimental group lowered significantly comparing to control group. The TG lowered from(2.81±1.32)mmol/L to(2.06±0.91)mmol/L，TC from(6.67±0.93)mmol/L to(5.49±0.95)mmol/L，LDL-C from(4.69±0.89)mmol/L to(3.83±1.02)mmol/L， and all the differences above were significant. The declining of serum lipid was related to the increasing of hyperlipidemia-related knowledge, exercise frequency and the decreasing of oil intaking. Conclusion Non-pharmacotherapy is to be effective for the patients with simple hyperlipidemia and it can be used as basic therapy.

Key words: Hyperlipidemia; Non-pharmacotherapy; Health habits teaching； Exercise therapy; Diet guidance

中图分类号:

R589.2

张敏1，2，徐贵发1. 单纯高脂血症患者非药物干预的疗效评价[J]. 山东大学学报(医学版), 2010, 48(8): 117-119.

ZHANG Min1，2, XU Gui-fa1. Effect of nonpharmacotherapy in decreasing the levels of serum lipid in simple hyperlipidemia patients[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2010, 48(8): 117-119.

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