关键词: 异甘草酸镁；肝炎，病毒性；高胆红素血症；肝纤维化

Abstract:

Objective    To evaluate the clinical efficacy of magnesium isoglycyrrhizinate in the management of virus hepatitis with hyperbilirubinemia. Methods    117 patients with virus hepatitis with hyperbilirubinemia were randomly divided into the therapy group and the control group. Besides routine therapy, patients in the therapy group received management of magnesium isoglycyrrhizinate. The serum biochemical parameters were determined in all patients at the onset and end of treatment. Results    Four weeks after the treatment, the total effective response was 82.5% in the therapy group and 70.4% in the control group with a significant difference (P=0.004). After four week follow up, the total effective response was 88.9% in the therapy group and 53.7% in the control group with a significant difference (P<0.001). The treatment with magnesium isoglycyrrhizinate was effective in reducing liver fibrosis and without significant side effects. Conclusion    Magnesium isoglycyrrhizinate is effective for virus hepatitis with hyperbilirubinemia.

Key words: Magnesium isoglycyrrhizinate; Hepatitis, viral hepatitis; Hyperbilirubinemia; Liver fibrosis